P06126 · CD1A_HUMAN
- ProteinT-cell surface glycoprotein CD1a
- GeneCD1A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids327 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Miscellaneous
During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endosome membrane | |
Cellular Component | external side of plasma membrane | |
Cellular Component | extracellular space | |
Cellular Component | membrane raft | |
Cellular Component | plasma membrane | |
Molecular Function | endogenous lipid antigen binding | |
Molecular Function | exogenous lipid antigen binding | |
Molecular Function | lipopeptide binding | |
Biological Process | adaptive immune response | |
Biological Process | antigen processing and presentation, endogenous lipid antigen via MHC class Ib | |
Biological Process | antigen processing and presentation, exogenous lipid antigen via MHC class Ib | |
Biological Process | immune response | |
Biological Process | positive regulation of T cell mediated cytotoxicity |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameT-cell surface glycoprotein CD1a
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP06126
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane raft ; Single-pass type I membrane protein
Endosome membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 17-300 | Extracellular | ||||
Sequence: NADGLKEPLSFHVTWIASFYNHSWKQNLVSGWLSDLQTHTWDSNSSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYAHELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIVLYWEHHSSV | ||||||
Transmembrane | 301-321 | Helical | ||||
Sequence: GFIILAVIVPLLLLIGLALWF | ||||||
Topological domain | 322-327 | Cytoplasmic | ||||
Sequence: RKRCFC |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_062522 | 22 | in dbSNP:rs3087217 | |||
Sequence: K → N | ||||||
Natural variant | VAR_010209 | 30 | in dbSNP:rs2269714 | |||
Sequence: T → I | ||||||
Natural variant | VAR_010210 | 68 | in dbSNP:rs2269715 | |||
Sequence: C → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 485 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MLFLLLPLLAVLPGDG | ||||||
Chain | PRO_0000014578 | 17-327 | T-cell surface glycoprotein CD1a | |||
Sequence: NADGLKEPLSFHVTWIASFYNHSWKQNLVSGWLSDLQTHTWDSNSSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYAHELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIVLYWEHHSSVGFIILAVIVPLLLLIGLALWFRKRCFC | ||||||
Glycosylation | 37 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 60 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 74 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 119↔183 | |||||
Sequence: CELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLSDTC | ||||||
Glycosylation | 145 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 223↔278 | |||||
Sequence: CHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSC |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P06126 | B2M P61769 | 2 | EBI-1036766, EBI-714718 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 184-291 | Ig-like | ||||
Sequence: PRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIV |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length327
- Mass (Da)37,077
- Last updated2010-02-09 v4
- ChecksumC575C3C538F0AA29
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 70-71 | in Ref. 7; AAA51933 | ||||
Sequence: WS → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M28825 EMBL· GenBank· DDBJ | AAA51931.1 EMBL· GenBank· DDBJ | mRNA | ||
M22167 EMBL· GenBank· DDBJ | AAA51932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22080 EMBL· GenBank· DDBJ | AAA51932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22163 EMBL· GenBank· DDBJ | AAA51932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22164 EMBL· GenBank· DDBJ | AAA51932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22165 EMBL· GenBank· DDBJ | AAA51932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22166 EMBL· GenBank· DDBJ | AAA51932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK312945 EMBL· GenBank· DDBJ | BAG35786.1 EMBL· GenBank· DDBJ | mRNA | ||
AL121986 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471121 EMBL· GenBank· DDBJ | EAW52843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471121 EMBL· GenBank· DDBJ | EAW52844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF142665 EMBL· GenBank· DDBJ | AAD37578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M27735 EMBL· GenBank· DDBJ | AAA51933.1 EMBL· GenBank· DDBJ | mRNA | ||
X04450 EMBL· GenBank· DDBJ | CAA28049.1 EMBL· GenBank· DDBJ | mRNA | ||
M14663 EMBL· GenBank· DDBJ | AAA51934.1 EMBL· GenBank· DDBJ | Genomic DNA |