P06024 · GC_SUHVF
- ProteinEnvelope glycoprotein C homolog
- GenegC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids479 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans (By similarity).
Plays also a role in host immune evasion by inhibiting the host complement cascade activation
Plays also a role in host immune evasion by inhibiting the host complement cascade activation
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | virion membrane | |
Biological Process | adhesion receptor-mediated virion attachment to host cell | |
Biological Process | symbiont entry into host cell | |
Biological Process | symbiont-mediated suppression of host complement activation | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEnvelope glycoprotein C homolog
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Varicellovirus > Varicellovirus suidalpha1 > Suid herpesvirus 1
- Virus hosts
Accessions
- Primary accessionP06024
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Single-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 23-451 | Virion surface | ||||
Sequence: PSTTTALDTTPNGGGGGNSSEGELSPSPPPTPAPASPEAGAVSTPPVPPPSVSRRKPPRNNNRTRVHGDKATAHGRKRIVCRERLFSARVGDAVSFGCAVFPRAGETFEVRFYRRGRFRSPDADPEYFDEPPRPELPRERLLFSSANASLAHADALAPVVVEGERATVANVSGEVSVRVAAADAETEGVYTWRVLSANGTEVRSANVSLLLYSQPEFGLSAPPVLFGEPFRAVCVVRDYYPRRSVRLRWFADEHPVDAAFVTNSTVADELGRRTRVSVVNVTRADVPGLAAADAADALAPSLRCEAVWYRDSVASQRFSEALRPHVYHPAAVSVRFVEGFAVCDGLCVPPEARLAWSDHAADTVYHLGACAEHPGLLNVRSARPLSDLDGPVDYTCRLEGLPSQLPVFEDTQRYDASPASVSWPVVSSM | ||||||
Transmembrane | 452-472 | Helical | ||||
Sequence: IVVIAGIGILAIVLVIMATCV | ||||||
Topological domain | 473-479 | Cytoplasmic | ||||
Sequence: YYRQAGP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MASLARAMLALLALYAAAIAAA | ||||||
Chain | PRO_0000038212 | 23-479 | Envelope glycoprotein C homolog | |||
Sequence: PSTTTALDTTPNGGGGGNSSEGELSPSPPPTPAPASPEAGAVSTPPVPPPSVSRRKPPRNNNRTRVHGDKATAHGRKRIVCRERLFSARVGDAVSFGCAVFPRAGETFEVRFYRRGRFRSPDADPEYFDEPPRPELPRERLLFSSANASLAHADALAPVVVEGERATVANVSGEVSVRVAAADAETEGVYTWRVLSANGTEVRSANVSLLLYSQPEFGLSAPPVLFGEPFRAVCVVRDYYPRRSVRLRWFADEHPVDAAFVTNSTVADELGRRTRVSVVNVTRADVPGLAAADAADALAPSLRCEAVWYRDSVASQRFSEALRPHVYHPAAVSVRFVEGFAVCDGLCVPPEARLAWSDHAADTVYHLGACAEHPGLLNVRSARPLSDLDGPVDYTCRLEGLPSQLPVFEDTQRYDASPASVSWPVVSSMIVVIAGIGILAIVLVIMATCVYYRQAGP | ||||||
Glycosylation | 40 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 84 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Disulfide bond | 103↔120 | |||||
Sequence: CRERLFSARVGDAVSFGC | ||||||
Glycosylation | 169 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 192 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 220 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 228 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Disulfide bond | 256↔326 | |||||
Sequence: CVVRDYYPRRSVRLRWFADEHPVDAAFVTNSTVADELGRRTRVSVVNVTRADVPGLAAADAADALAPSLRC | ||||||
Glycosylation | 285 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 302 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Disulfide bond | 365↔418 | |||||
Sequence: CDGLCVPPEARLAWSDHAADTVYHLGACAEHPGLLNVRSARPLSDLDGPVDYTC | ||||||
Disulfide bond | 369↔392 | |||||
Sequence: CVPPEARLAWSDHAADTVYHLGAC |
Keywords
- PTM
PTM databases
Interaction
Subunit
Interacts with host complement component C3; this interaction inhibits host immune response by disregulating complement cascade.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-46 | Polar residues | ||||
Sequence: TTALDTTPNGGGGGNSSEGEL | ||||||
Region | 26-96 | Disordered | ||||
Sequence: TTALDTTPNGGGGGNSSEGELSPSPPPTPAPASPEAGAVSTPPVPPPSVSRRKPPRNNNRTRVHGDKATAH | ||||||
Compositional bias | 47-77 | Pro residues | ||||
Sequence: SPSPPPTPAPASPEAGAVSTPPVPPPSVSRR | ||||||
Region | 75-82 | HDB1 | ||||
Sequence: SRRKPPRN | ||||||
Region | 95-101 | HDB2 | ||||
Sequence: AHGRKRI | ||||||
Region | 135-140 | HDB3 | ||||
Sequence: YRRGRF |
Domain
The three heparin-binding domains (HDB1, HDB2 and HDB3) mediate virus attachment through specific arrangements of basic residues.
Sequence similarities
Belongs to the herpesviridae glycoprotein C family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length479
- Mass (Da)51,207
- Last updated1987-08-13 v1
- ChecksumDE8FEA4B2521D17F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-46 | Polar residues | ||||
Sequence: TTALDTTPNGGGGGNSSEGEL | ||||||
Compositional bias | 47-77 | Pro residues | ||||
Sequence: SPSPPPTPAPASPEAGAVSTPPVPPPSVSRR |