P05814 · CASB_HUMAN

  • Protein
    Beta-casein
  • Gene
    CSN2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Important role in determination of the surface properties of the casein micelles.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioncalcium ion binding
Molecular Functioncysteine-type endopeptidase inhibitor activity
Molecular Functionenzyme inhibitor activity
Biological Processcalcium ion transport
Biological Processlactation
Biological Processnegative regulation of cysteine-type endopeptidase activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-casein

Gene names

    • Name
      CSN2
    • Synonyms
      CASB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P05814
  • Secondary accessions
    • Q4VAZ9
    • Q9UCM5

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 350 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

Protein family/group databases

PTM/Processing

Features

Showing features for signal, chain, modified residue.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_000000447516-226Beta-casein
Modified residue18Phosphothreonine; in form 5-P
Modified residue21Phosphoserine; in form 4-P and form 5-P
Modified residue23Phosphoserine; in form 3-P, form 4-P and form 5-P
Modified residue24Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P
Modified residue25Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P

Post-translational modification

Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Mammary gland specific. Secreted in milk.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P05814FHL2 Q141924EBI-1642112, EBI-701903
BINARY P05814UBQLN2 Q9UHD96EBI-1642112, EBI-947187

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    226
  • Mass (Da)
    25,382
  • Last updated
    1992-08-01 v4
  • Checksum
    2619C524EA1358E8
MKVLILACLVALALARETIESLSSSEESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMPVLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNPTHQIYPVTQPLAPVHNPISV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict30in Ref. 6; AA sequence
Sequence conflict34in Ref. 1; CAA39270
Sequence conflict48-50in Ref. 6; AA sequence
Sequence conflict120in Ref. 6; AA sequence
Sequence conflict133in Ref. 3; CAA34916
Sequence conflict140in Ref. 3; CAA34916
Sequence conflict149in Ref. 6; AA sequence
Sequence conflict173in Ref. 6; AA sequence
Sequence conflict182-184in Ref. 6; AA sequence
Sequence conflict188in Ref. 6; AA sequence
Sequence conflict207in Ref. 6; AA sequence
Sequence conflict214-222in Ref. 6; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X55739
EMBL· GenBank· DDBJ
CAA39270.1
EMBL· GenBank· DDBJ
mRNA
AF027807
EMBL· GenBank· DDBJ
AAC82978.1
EMBL· GenBank· DDBJ
Genomic DNA
X17070
EMBL· GenBank· DDBJ
CAA34916.1
EMBL· GenBank· DDBJ
mRNA
BC069554
EMBL· GenBank· DDBJ
AAH69554.1
EMBL· GenBank· DDBJ
mRNA
BC096194
EMBL· GenBank· DDBJ
AAH96194.1
EMBL· GenBank· DDBJ
mRNA
BC096195
EMBL· GenBank· DDBJ
AAH96195.1
EMBL· GenBank· DDBJ
mRNA
BC096196
EMBL· GenBank· DDBJ
AAH96196.1
EMBL· GenBank· DDBJ
mRNA
BC096197
EMBL· GenBank· DDBJ
AAH96197.1
EMBL· GenBank· DDBJ
mRNA
X13766
EMBL· GenBank· DDBJ
CAA32017.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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