P05814 · CASB_HUMAN
- ProteinBeta-casein
- GeneCSN2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids226 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Important role in determination of the surface properties of the casein micelles.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | cysteine-type endopeptidase inhibitor activity | |
Molecular Function | enzyme inhibitor activity | |
Biological Process | calcium ion transport | |
Biological Process | lactation | |
Biological Process | negative regulation of cysteine-type endopeptidase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameBeta-casein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP05814
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 350 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
Protein family/group databases
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MKVLILACLVALALA | ||||||
Chain | PRO_0000004475 | 16-226 | Beta-casein | |||
Sequence: RETIESLSSSEESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMPVLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNPTHQIYPVTQPLAPVHNPISV | ||||||
Modified residue | 18 | Phosphothreonine; in form 5-P | ||||
Sequence: T | ||||||
Modified residue | 21 | Phosphoserine; in form 4-P and form 5-P | ||||
Sequence: S | ||||||
Modified residue | 23 | Phosphoserine; in form 3-P, form 4-P and form 5-P | ||||
Sequence: S | ||||||
Modified residue | 24 | Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P | ||||
Sequence: S | ||||||
Modified residue | 25 | Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P | ||||
Sequence: S |
Post-translational modification
Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Mammary gland specific. Secreted in milk.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P05814 | FHL2 Q14192 | 4 | EBI-1642112, EBI-701903 | |
BINARY | P05814 | UBQLN2 Q9UHD9 | 6 | EBI-1642112, EBI-947187 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length226
- Mass (Da)25,382
- Last updated1992-08-01 v4
- Checksum2619C524EA1358E8
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 30 | in Ref. 6; AA sequence | ||||
Sequence: T → P | ||||||
Sequence conflict | 34 | in Ref. 1; CAA39270 | ||||
Sequence: Missing | ||||||
Sequence conflict | 48-50 | in Ref. 6; AA sequence | ||||
Sequence: EDE → TDQ | ||||||
Sequence conflict | 120 | in Ref. 6; AA sequence | ||||
Sequence: S → Q | ||||||
Sequence conflict | 133 | in Ref. 3; CAA34916 | ||||
Sequence: L → V | ||||||
Sequence conflict | 140 | in Ref. 3; CAA34916 | ||||
Sequence: H → Q | ||||||
Sequence conflict | 149 | in Ref. 6; AA sequence | ||||
Sequence: L → S | ||||||
Sequence conflict | 173 | in Ref. 6; AA sequence | ||||
Sequence: Q → E | ||||||
Sequence conflict | 182-184 | in Ref. 6; AA sequence | ||||
Sequence: QVV → EVL | ||||||
Sequence conflict | 188 | in Ref. 6; AA sequence | ||||
Sequence: Q → V | ||||||
Sequence conflict | 207 | in Ref. 6; AA sequence | ||||
Sequence: T → P | ||||||
Sequence conflict | 214-222 | in Ref. 6; AA sequence | ||||
Sequence: TQPLAPVHN → PEPSTTZABH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X55739 EMBL· GenBank· DDBJ | CAA39270.1 EMBL· GenBank· DDBJ | mRNA | ||
AF027807 EMBL· GenBank· DDBJ | AAC82978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X17070 EMBL· GenBank· DDBJ | CAA34916.1 EMBL· GenBank· DDBJ | mRNA | ||
BC069554 EMBL· GenBank· DDBJ | AAH69554.1 EMBL· GenBank· DDBJ | mRNA | ||
BC096194 EMBL· GenBank· DDBJ | AAH96194.1 EMBL· GenBank· DDBJ | mRNA | ||
BC096195 EMBL· GenBank· DDBJ | AAH96195.1 EMBL· GenBank· DDBJ | mRNA | ||
BC096196 EMBL· GenBank· DDBJ | AAH96196.1 EMBL· GenBank· DDBJ | mRNA | ||
BC096197 EMBL· GenBank· DDBJ | AAH96197.1 EMBL· GenBank· DDBJ | mRNA | ||
X13766 EMBL· GenBank· DDBJ | CAA32017.1 EMBL· GenBank· DDBJ | mRNA |