P05709 · SIM_DROME
- ProteinProtein single-minded
- Genesim
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids697 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord (PubMed:12221007, PubMed:1760843, PubMed:9840810).
Required to correctly specify the formation of the central brain complex, which controls walking behavior (PubMed:12221007, PubMed:1760843, PubMed:9840810).
Also required for correct patterning of the embryonic genital disk and anal pad anlage (PubMed:12221007, PubMed:1760843, PubMed:9840810).
Plays a role in synapse development (PubMed:23644463).
Required to correctly specify the formation of the central brain complex, which controls walking behavior (PubMed:12221007, PubMed:1760843, PubMed:9840810).
Also required for correct patterning of the embryonic genital disk and anal pad anlage (PubMed:12221007, PubMed:1760843, PubMed:9840810).
Plays a role in synapse development (PubMed:23644463).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein single-minded
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP05709
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Mutations result in the loss of the precursor cells that give rise to midline cells of the embryonic central nervous system.
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 65 | In allele sim-J1-47; temperature sensitive embryonic midline axon phenotype. | ||||
Sequence: S → F | ||||||
Natural variant | 406-414 | in strain: Berkeley | ||||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000127438 | 1-697 | Protein single-minded | |||
Sequence: MTNHRRVRKDCYESRLHDIAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHLMEQQHLQYQYATW |
Proteomic databases
Expression
Interaction
Subunit
Efficient DNA binding requires dimerization with another bHLH protein.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P05709 | tgo O15945 | 3 | EBI-88929, EBI-172695 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 24-77 | bHLH | ||||
Sequence: AMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMR | ||||||
Domain | 100-172 | PAS 1 | ||||
Sequence: IKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQH | ||||||
Domain | 266-336 | PAS 2 | ||||
Sequence: PSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKG | ||||||
Region | 406-446 | 14 X 3 AA repeats of A-A-Q (approximate) | ||||
Sequence: AAQAAQAAQAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQ | ||||||
Region | 496-537 | Disordered | ||||
Sequence: QPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDS | ||||||
Compositional bias | 502-537 | Polar residues | ||||
Sequence: VPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDS | ||||||
Region | 554-584 | Disordered | ||||
Sequence: SSSSVGGGTASSAGGGSSASASSSGVYSTEM | ||||||
Region | 621-655 | Disordered | ||||
Sequence: SANSNSCSSSSESERQLSTGNASIVNETSPSQTTY |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P05709-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Length697
- Mass (Da)76,475
- Last updated2003-05-23 v3
- Checksum588414A4A17101AD
P05709-2
- NameB
- Differences from canonical
- 1-24: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4KFY1 | A0A0B4KFY1_DROME | sim | 672 | ||
A0A0B4KH05 | A0A0B4KH05_DROME | sim | 675 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_011812 | 1-24 | in isoform B | |||
Sequence: Missing | ||||||
Sequence conflict | 151 | in Ref. 1; AAC64519 | ||||
Sequence: I → Y | ||||||
Compositional bias | 502-537 | Polar residues | ||||
Sequence: VPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDS |
Polymorphism
Berkeley strain has 11 A-A-Q repeats.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF071934 EMBL· GenBank· DDBJ | AAC64519.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AE014297 EMBL· GenBank· DDBJ | AAF54902.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAN14343.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY129457 EMBL· GenBank· DDBJ | AAM76199.1 EMBL· GenBank· DDBJ | mRNA | ||
M19020 EMBL· GenBank· DDBJ | AAA28900.1 EMBL· GenBank· DDBJ | mRNA |