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P05083 · ARLY2_CHICK

  • Protein
    Argininosuccinate lyase
  • Gene
    ASL2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase.

Miscellaneous

It is uncertain if this gene is expressed.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.

Features

Showing features for binding site, active site, site.

146650100150200250300350400450
Type
IDPosition(s)Description
Binding site272-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A
Binding site1142-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A
Binding site1592-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain C
Active site160Proton acceptor
Active site281Proton donor
Binding site2892-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain B
Site294Increases basicity of active site His
Binding site3212-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A
Binding site3262-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A
Binding site3292-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionargininosuccinate lyase activity
Molecular Functionstructural constituent of eye lens
Biological Processarginine biosynthetic process via ornithine
Biological Processarginine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Argininosuccinate lyase
  • EC number
  • Short names
    ASAL
  • Alternative names
    • Arginosuccinase
    • Delta crystallin II
    • Delta-2 crystallin

Gene names

    • Name
      ASL2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    P05083

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001377201-466Argininosuccinate lyase

Proteomic databases

Expression

Tissue specificity

Eye lens.

Gene expression databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    466
  • Mass (Da)
    51,044
  • Last updated
    1987-08-13 v1
  • MD5 Checksum
    02E4865FB7A5B4B28DB05FD2521D3248
MASEGDKLWGGRFSGSTDPIMEMLNSSIACDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLLLKSSISVISTHLLQLIKTLVERAATEIDVIMPGYTHLQKALPIRWSQFLLSHAVALIRDSERLGEVKKRMSVLPLGSGALAGNPLEIDRELLRSELDFASISLNSMDAISERDFVVELLSVATLLMIHLSKLAEDLIIFSTTEFGFVTLSDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAVLMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQVNKENMEKALTPELLSTDLALYLVRKGMPFRQAHVASGKAVHLAETKGIAINKLTLEDLKSISPLFASDVSQVFNIVNSVEQYTAVGGTAKSSVTAQIEQLRELLKKQKEQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M10806
EMBL· GenBank· DDBJ
AAA48727.1
EMBL· GenBank· DDBJ
Genomic DNA
X02188
EMBL· GenBank· DDBJ
CAA26129.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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