P05083 · ARLY2_CHICK
- ProteinArgininosuccinate lyase
- GeneASL2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids466 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase.
Miscellaneous
It is uncertain if this gene is expressed.
Catalytic activity
- 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine
Pathway
Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 27 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A | |||
Binding site | 114 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A | |||
Binding site | 159 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain C | |||
Active site | 160 | Proton acceptor | |||
Active site | 281 | Proton donor | |||
Binding site | 289 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain B | |||
Site | 294 | Increases basicity of active site His | |||
Binding site | 321 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A | |||
Binding site | 326 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A | |||
Binding site | 329 | 2-(N(omega)-L-arginino)succinate (UniProtKB | ChEBI); ligand shared between tetrameric partners; in chain A | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | argininosuccinate lyase activity | |
Molecular Function | structural constituent of eye lens | |
Biological Process | arginine biosynthetic process via ornithine | |
Biological Process | arginine metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArgininosuccinate lyase
- EC number
- Short namesASAL
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionP05083
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000137720 | 1-466 | Argininosuccinate lyase | ||
Proteomic databases
Expression
Interaction
Structure
Sequence
- Sequence statusComplete
- Length466
- Mass (Da)51,044
- Last updated1987-08-13 v1
- MD5 Checksum02E4865FB7A5B4B28DB05FD2521D3248
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M10806 EMBL· GenBank· DDBJ | AAA48727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X02188 EMBL· GenBank· DDBJ | CAA26129.1 EMBL· GenBank· DDBJ | Genomic DNA |