P05029 · AT1B1_TETCF
- ProteinSodium/potassium-transporting ATPase subunit beta-1
- Geneatp1b1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids305 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | sodium:potassium-exchanging ATPase complex | |
Molecular Function | ATPase activator activity | |
Biological Process | intracellular potassium ion homeostasis | |
Biological Process | intracellular sodium ion homeostasis | |
Biological Process | potassium ion import across plasma membrane | |
Biological Process | sodium ion export across plasma membrane |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium/potassium-transporting ATPase subunit beta-1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Elasmobranchii > Batoidea > Torpediniformes > Torpedinidae > Tetronarce
Accessions
- Primary accessionP05029
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-32 | Cytoplasmic | ||||
Sequence: MAREKSTDDGGGWKKFLWDSEKKQVLGRTGTS | ||||||
Transmembrane | 33-53 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: WFKIFVFYLIFYGCLAGIFIG | ||||||
Topological domain | 54-305 | Extracellular | ||||
Sequence: TIQVMLLTISDFEPKYQDRVAPPGLSHSPYAVKTEISFSVSNPNSYENHVNGLKELLKNYNESKQDGNTPFEDCGVIPADYITRGPIEESQGQKRVCRFLLQWLKNCSGIDDPSYGYSEGKPCIIAKLNRILGFYPKPPKNGTDLPEALQANYNQYVLPIHCQAKKEEDKVRIGTIEYFGMGGVGGFPLQYYPYYGKRLQKNYLQPLVGIQFTNLTHNVELRVECKVFGDNIAYSEKDRSLGRFEVKIEVKS |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000219116 | 1-305 | Sodium/potassium-transporting ATPase subunit beta-1 | |||
Sequence: MAREKSTDDGGGWKKFLWDSEKKQVLGRTGTSWFKIFVFYLIFYGCLAGIFIGTIQVMLLTISDFEPKYQDRVAPPGLSHSPYAVKTEISFSVSNPNSYENHVNGLKELLKNYNESKQDGNTPFEDCGVIPADYITRGPIEESQGQKRVCRFLLQWLKNCSGIDDPSYGYSEGKPCIIAKLNRILGFYPKPPKNGTDLPEALQANYNQYVLPIHCQAKKEEDKVRIGTIEYFGMGGVGGFPLQYYPYYGKRLQKNYLQPLVGIQFTNLTHNVELRVECKVFGDNIAYSEKDRSLGRFEVKIEVKS | ||||||
Glycosylation | 114 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 127↔150 | |||||
Sequence: CGVIPADYITRGPIEESQGQKRVC | ||||||
Glycosylation | 159 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 160↔176 | |||||
Sequence: CSGIDDPSYGYSEGKPC | ||||||
Glycosylation | 194 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 215↔278 | |||||
Sequence: CQAKKEEDKVRIGTIEYFGMGGVGGFPLQYYPYYGKRLQKNYLQPLVGIQFTNLTHNVELRVEC | ||||||
Glycosylation | 267 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Subunit
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
Structure
Sequence
- Sequence statusComplete
- Length305
- Mass (Da)34,673
- Last updated1987-08-13 v1
- ChecksumBC13191F8D597563