P05029 · AT1B1_TETCF

Function

function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentsodium:potassium-exchanging ATPase complex
Molecular FunctionATPase activator activity
Biological Processintracellular potassium ion homeostasis
Biological Processintracellular sodium ion homeostasis
Biological Processpotassium ion import across plasma membrane
Biological Processsodium ion export across plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/potassium-transporting ATPase subunit beta-1
  • Alternative names
    • Sodium/potassium-dependent ATPase subunit beta-1

Gene names

    • Name
      atp1b1

Organism names

Accessions

  • Primary accession
    P05029

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-32Cytoplasmic
Transmembrane33-53Helical; Signal-anchor for type II membrane protein
Topological domain54-305Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00002191161-305Sodium/potassium-transporting ATPase subunit beta-1
Glycosylation114N-linked (GlcNAc...) asparagine
Disulfide bond127↔150
Glycosylation159N-linked (GlcNAc...) asparagine
Disulfide bond160↔176
Glycosylation194N-linked (GlcNAc...) asparagine
Disulfide bond215↔278
Glycosylation267N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    34,673
  • Last updated
    1987-08-13 v1
  • Checksum
    BC13191F8D597563
MAREKSTDDGGGWKKFLWDSEKKQVLGRTGTSWFKIFVFYLIFYGCLAGIFIGTIQVMLLTISDFEPKYQDRVAPPGLSHSPYAVKTEISFSVSNPNSYENHVNGLKELLKNYNESKQDGNTPFEDCGVIPADYITRGPIEESQGQKRVCRFLLQWLKNCSGIDDPSYGYSEGKPCIIAKLNRILGFYPKPPKNGTDLPEALQANYNQYVLPIHCQAKKEEDKVRIGTIEYFGMGGVGGFPLQYYPYYGKRLQKNYLQPLVGIQFTNLTHNVELRVECKVFGDNIAYSEKDRSLGRFEVKIEVKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X03471
EMBL· GenBank· DDBJ
CAA27188.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp