P04950 · OPS3_DROME
- ProteinOpsin Rh3
- GeneRh3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids383 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Miscellaneous
Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells.
Opsin Rh3 is sensitive to UV light.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled photoreceptor activity | |
Biological Process | absorption of UV light | |
Biological Process | cellular response to light stimulus | |
Biological Process | detection of UV | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | phototransduction | |
Biological Process | phototransduction, UV | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOpsin Rh3
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP04950
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-57 | Extracellular | ||||
Sequence: MESGNVSSSLFGNVSTALRPEARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESM | ||||||
Transmembrane | 58-82 | Helical; Name=1 | ||||
Sequence: NYLLGTLYIFFTLMSMLGNGLVIWV | ||||||
Topological domain | 83-94 | Cytoplasmic | ||||
Sequence: FSAAKSLRTPSN | ||||||
Transmembrane | 95-119 | Helical; Name=2 | ||||
Sequence: ILVINLAFCDFMMMVKTPIFIYNSF | ||||||
Topological domain | 120-133 | Extracellular | ||||
Sequence: HQGYALGHLGCQIF | ||||||
Transmembrane | 134-153 | Helical; Name=3 | ||||
Sequence: GIIGSYTGIAAGATNAFIAY | ||||||
Topological domain | 154-171 | Cytoplasmic | ||||
Sequence: DRFNVITRPMEGKMTHGK | ||||||
Transmembrane | 172-196 | Helical; Name=4 | ||||
Sequence: AIAMIIFIYMYATPWVVACYTETWG | ||||||
Topological domain | 197-220 | Extracellular | ||||
Sequence: RFVPEGYLTSCTFDYLTDNFDTRL | ||||||
Transmembrane | 221-248 | Helical; Name=5 | ||||
Sequence: FVACIFFFSFVCPTTMITYYYSQIVGHV | ||||||
Topological domain | 249-284 | Cytoplasmic | ||||
Sequence: FSHEKALRDQAKKMNVESLRSNVDKNKETAEIRIAK | ||||||
Transmembrane | 285-308 | Helical; Name=6 | ||||
Sequence: AAITICFLFFCSWTPYGVMSLIGA | ||||||
Topological domain | 309-316 | Extracellular | ||||
Sequence: FGDKTLLT | ||||||
Transmembrane | 317-341 | Helical; Name=7 | ||||
Sequence: PGATMIPACACKMVACIDPFVYAIS | ||||||
Topological domain | 342-383 | Cytoplasmic | ||||
Sequence: HPRYRMELQKRCPWLALNEKAPESSAVASTSTTQEPQQTTAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000197627 | 1-383 | Opsin Rh3 | |||
Sequence: MESGNVSSSLFGNVSTALRPEARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVKTPIFIYNSFHQGYALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFVPEGYLTSCTFDYLTDNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMNVESLRSNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLALNEKAPESSAVASTSTTQEPQQTTAA | ||||||
Glycosylation | 13 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 130↔207 | |||||
Sequence: CQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFVPEGYLTSC | ||||||
Modified residue | 328 | N6-(retinylidene)lysine | ||||
Sequence: K |
Post-translational modification
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 362-383 | Disordered | ||||
Sequence: APESSAVASTSTTQEPQQTTAA | ||||||
Compositional bias | 364-383 | Polar residues | ||||
Sequence: ESSAVASTSTTQEPQQTTAA |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length383
- Mass (Da)42,940
- Last updated1987-08-13 v1
- ChecksumBF9D009A25CA6343
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 364-383 | Polar residues | ||||
Sequence: ESSAVASTSTTQEPQQTTAA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y00043 EMBL· GenBank· DDBJ | CAA68259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17718 EMBL· GenBank· DDBJ | AAA28854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAG22157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF184224 EMBL· GenBank· DDBJ | AAD55735.1 EMBL· GenBank· DDBJ | mRNA |