These results indicate that stress conditions most probably altered the cell redox equilibrium thus influencing the antioxidant response in brain cortex.
fenofibrate almost completely abolished GM-induced reactive oxygen species generation which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes including catalase and superoxide dismutase (SOD)-1.
These results indicate that CAT expression is significantly decreased in the hippocampi of aged animals and decreased CAT expression may be closely associated with aging.
Data show that nuclear factor erythroid 2-related factor (Nrf2) superoxide dismutase Sod1 and catalase antioxidant systems are downregulated in isolated arteries and vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP).
Catalase promoter region (-185 to +52) that contains binding sites for C/EBP-beta showed an augmentation in the methylation level along with a change in methylation pattern of CpG islands in response to PTU treatment
mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1 SOD2 CAT and GPx4 in rat peripheral blood leukocytes.
Decrease in Sirtuin1 (SIRT1) and nuclear factor erythroid 2-related factor (Nrf2) and increase in nuclear factor kappa B (NFkappaB) gene expression in diabetes were associated with a decrease in CAT and GPx mRNA expression.
Results suggest that the effects of estrogen on the cell-mediated immune responses are mediated through specific estrogen receptors alpha and beta and antioxidant enzymes superoxide dismutase (SOD) catalase (CAT) and glutathione peroxidase (GPx).
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