P04761 · ACM1_PIG

  • Protein
    Muscarinic acetylcholine receptor M1
  • Gene
    CHRM1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Molecular FunctionG protein-coupled acetylcholine receptor activity
Molecular FunctionG protein-coupled serotonin receptor activity
Biological Processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Biological Processchemical synaptic transmission
Biological Processcognition
Biological Processentrainment of circadian clock
Biological ProcessG protein-coupled acetylcholine receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processphototransduction, visible light
Biological Processregulation of locomotion
Biological Processsaliva secretion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Muscarinic acetylcholine receptor M1

Gene names

    • Name
      CHRM1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    P04761

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-22Extracellular
Transmembrane23-48Helical; Name=1
Topological domain49-62Cytoplasmic
Transmembrane63-84Helical; Name=2
Topological domain85-95Extracellular
Transmembrane96-121Helical; Name=3
Topological domain122-142Cytoplasmic
Transmembrane143-164Helical; Name=4
Topological domain165-185Extracellular
Transmembrane186-209Helical; Name=5
Topological domain210-366Cytoplasmic
Transmembrane367-390Helical; Name=6
Topological domain391-397Extracellular
Transmembrane398-420Helical; Name=7
Topological domain421-460Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000690181-460Muscarinic acetylcholine receptor M1
Glycosylation2N-linked (GlcNAc...) asparagine
Glycosylation12N-linked (GlcNAc...) asparagine
Disulfide bond98↔178
Modified residue230Phosphothreonine
Modified residue428Phosphothreonine
Modified residue451Phosphoserine
Modified residue455Phosphothreonine
Modified residue457Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with GPRASP2 (By similarity).
Interacts with TMEM147 (By similarity).

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region225-256Disordered
Compositional bias231-248Polar residues
Region274-296Disordered
Region310-351Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    51,419
  • Last updated
    1987-08-13 v1
  • Checksum
    C025C70EA43BC2AD
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPAKQPPRSSPNTVKRPTRKGRERAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFIVTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias231-248Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X04413
EMBL· GenBank· DDBJ
CAA28003.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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