P04761 · ACM1_PIG
- ProteinMuscarinic acetylcholine receptor M1
- GeneCHRM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids460 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled acetylcholine receptor activity | |
Molecular Function | G protein-coupled serotonin receptor activity | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | |
Biological Process | chemical synaptic transmission | |
Biological Process | cognition | |
Biological Process | entrainment of circadian clock | |
Biological Process | G protein-coupled acetylcholine receptor signaling pathway | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
Biological Process | phototransduction, visible light | |
Biological Process | regulation of locomotion | |
Biological Process | saliva secretion |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMuscarinic acetylcholine receptor M1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionP04761
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Postsynaptic cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-22 | Extracellular | |||
Transmembrane | 23-48 | Helical; Name=1 | |||
Topological domain | 49-62 | Cytoplasmic | |||
Transmembrane | 63-84 | Helical; Name=2 | |||
Topological domain | 85-95 | Extracellular | |||
Transmembrane | 96-121 | Helical; Name=3 | |||
Topological domain | 122-142 | Cytoplasmic | |||
Transmembrane | 143-164 | Helical; Name=4 | |||
Topological domain | 165-185 | Extracellular | |||
Transmembrane | 186-209 | Helical; Name=5 | |||
Topological domain | 210-366 | Cytoplasmic | |||
Transmembrane | 367-390 | Helical; Name=6 | |||
Topological domain | 391-397 | Extracellular | |||
Transmembrane | 398-420 | Helical; Name=7 | |||
Topological domain | 421-460 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000069018 | 1-460 | Muscarinic acetylcholine receptor M1 | ||
Glycosylation | 2 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 12 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 98↔178 | ||||
Modified residue | 230 | Phosphothreonine | |||
Modified residue | 428 | Phosphothreonine | |||
Modified residue | 451 | Phosphoserine | |||
Modified residue | 455 | Phosphothreonine | |||
Modified residue | 457 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with GPRASP2 (By similarity).
Interacts with TMEM147 (By similarity).
Interacts with TMEM147 (By similarity).
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 225-256 | Disordered | |||
Compositional bias | 231-248 | Polar residues | |||
Region | 274-296 | Disordered | |||
Region | 310-351 | Disordered | |||
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length460
- Mass (Da)51,419
- Last updated1987-08-13 v1
- ChecksumC025C70EA43BC2AD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 231-248 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X04413 EMBL· GenBank· DDBJ | CAA28003.1 EMBL· GenBank· DDBJ | mRNA |