P04718 · RBL2_RHORU

  • Protein
    Ribulose bisphosphate carboxylase
  • Gene
    cbbM
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site111substrate; in homodimeric partner
Active site166Proton acceptor
Binding site168substrate
Binding site191Mg2+ (UniProtKB | ChEBI); via carbamate group
Binding site193Mg2+ (UniProtKB | ChEBI)
Binding site194Mg2+ (UniProtKB | ChEBI)
Active site287Proton acceptor
Binding site288substrate
Binding site321substrate
Site329Transition state stabilizer
Binding site368substrate

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionmonooxygenase activity
Molecular Functionribulose-bisphosphate carboxylase activity
Biological Processreductive pentose-phosphate cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribulose bisphosphate carboxylase
  • EC number
  • Short names
    RuBisCO

Gene names

    • Name
      cbbM
    • Synonyms
      cbbL2, rbpL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Rhodospirillaceae > Rhodospirillum

Accessions

  • Primary accession
    P04718
  • Secondary accessions
    • P19365
    • P72313

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis193Loss of activity, decreased affinity for Mg2+.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000626661-466Ribulose bisphosphate carboxylase
Modified residue191N6-carboxylysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    466
  • Mass (Da)
    50,504
  • Last updated
    1987-08-13 v1
  • Checksum
    37D8C0076CAF7D54
MDQSSRYVNLALKEEDLIAGGEHVLCAYIMKPKAGYGYVATAAHFAAESSTGTNVEVCTTDDFTRGVDALVYEVDEARELTKIAYPVALFHRNITDGKAMIASFLTLTMGNNQGMGDVEYAKMHDFYVPEAYRALFDGPSVNISALWKVLGRPEVDGGLVVGTIIKPKLGLRPKPFAEACHAFWLGGDFIKNDEPQGNQPFAPLRDTIALVADAMRRAQDETGEAKLFSANITADDPFEIIARGEYVLETFGENASHVALLVDGYVAGAAAITTARRRFPDNFLHYHRAGHGAVTSPQSKRGYTAFVHCKMARLQGASGIHTGTMGFGKMEGESSDRAIAYMLTQDEAQGPFYRQSWGGMKACTPIISGGMNALRMPGFFENLGNANVILTAGGGAFGHIDGPVAGARSLRQAWQAWRDGVPVLDYAREHKELARAFESFPGDADQIYPGWRKALGVEDTRSALPA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X00286
EMBL· GenBank· DDBJ
CAA25080.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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