High-resolution structure of the oligomerization domain of p53 by multidimensional NMR.Clore G.M., Omichinski J.G., Sakaguchi K., Zambrano N., Sakamoto H., Appella E., Gronenborn A.M.View abstractCited forSTRUCTURE BY NMR OF 319-360CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 265:386-391 (1994)Cited in1
Solution structure of the tetrameric minimum transforming domain of p53.Lee W., Harvey T.S., Yin Y., Yau P., Litchfield D., Arrowsmith C.H.View abstractCited forSTRUCTURE BY NMR OF 325-355CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Struct. Biol. 1:877-890 (1994)Cited in1
Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.McCoy M., Stavridi E.S., Waterman J.L., Wieczorek A.M., Opella S.J., Halazonetis T.D.View abstractCited forSTRUCTURE BY NMR OF 326-354CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 16:6230-6236 (1997)Cited in1
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 94-289CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 265:346-355 (1994)Cited in1
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.Jeffrey P.D., Gorina S., Pavletich N.P.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 325-356CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 267:1498-1502 (1995)Cited in1
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.Kussie P.H., Gorina S., Marechal V., Elenbaas B., Moreau J., Levine A.J., Pavletich N.P.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 13-29 IN COMPLEX WITH MDM2CategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 274:948-953 (1996)Cited in3
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.Gorina S., Pavletich N.P.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 97-287 IN COMPLEX WITH 53BP2CategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 274:1001-1005 (1996)Cited in2
Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.Joerger A.C., Allen M.D., Fersht A.R.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 94-312 IN COMPLEX WITH ZINC IONS, SUBUNITCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:1291-1296 (2004)Cited in1Mapped to99+
Structural basis of DNA recognition by p53 tetramers.Kitayner M., Rozenberg H., Kessler N., Rabinovich D., Shaulov L., Haran T.E., Shakked Z.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 94-293 IN COMPLEX WITH DNA AND ZINC IONS, SUBUNITCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 22:741-753 (2006)Cited in1
Molecular recognition of p53 and MDM2 by USP7/HAUSP.Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith C.H., Frappier L.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 358-367 IN COMPLEX WITH USP7, INTERACTION WITH USP7CategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Struct. Mol. Biol. 13:285-291 (2006)Cited in3Mapped to99+
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.Hu M., Gu L., Li M., Jeffrey P.D., Gu W., Shi Y.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 360-368 IN COMPLEX WITH USP7, MUTAGENESIS OF PRO-359; GLY-361 AND SER-362, INTERACTION WITH USP7CategoriesDisease & Variants, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 4:228-239 (2006)Cited in3Mapped to6
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.West L.E., Roy S., Lachmi-Weiner K., Hayashi R., Shi X., Appella E., Kutateladze T.G., Gozani O.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 377-386, METHYLATION AT LYS-382, MUTAGENESIS OF LYS-382, INTERACTION WITH L3MBTL1CategoriesPTM / Processing, Disease & Variants, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 285:37725-37732 (2010)Cited in3Mapped to99+
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.Joerger A.C., Ang H.C., Fersht A.R.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 94-312 IN COMPLEX WITH ZINC IONSCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 103:15056-15061 (2006)Cited in1
Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution.Tu C., Tan Y.H., Shaw G., Zhou Z., Bai Y., Luo R., Ji X.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 94-292 OF VARIANT GLN-282CategoriesSequences, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCActa Crystallogr. D 64:471-477 (2008)Cited in1Mapped to99+
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.Boeckler F.M., Joerger A.C., Jaggi G., Rutherford T.J., Veprintsev D.B., Fersht A.R.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 94-312 OF VARIANT CYS-202 IN COMPLEX WITH ZINC IONS AND PHIKAN083CategoriesSequences, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 105:10360-10365 (2008)Cited in1Mapped to99+
Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.Suad O., Rozenberg H., Brosh R., Diskin-Posner Y., Kessler N., Shimon L.J., Frolow F., Liran A., Rotter V., Shakked Z.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 94-293 OF VARIANT SER-249 IN COMPLEX WITH DNACategoriesSequences, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Mol. Biol. 385:249-265 (2009)Cited in1Mapped to99+
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.Khoo K.H., Joerger A.C., Freund S.M., Fersht A.R.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 94-310 IN COMPLEX WITH ZINC IONSCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProtein Eng. Des. Sel. 22:421-430 (2009)Cited in1
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.Basse N., Kaar J.L., Settanni G., Joerger A.C., Rutherford T.J., Fersht A.R.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 94-312 OF VARIANT CYS-220 IN COMPLEX WITH ZINC IONSCategoriesSequences, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCChem. Biol. 17:46-56 (2010)Cited in1
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.Kitayner M., Rozenberg H., Rohs R., Suad O., Rabinovich D., Honig B., Shakked Z.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 94-293 IN COMPLEX WITH DNA AND ZINC IONS, SUBUNITCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Struct. Mol. Biol. 17:423-429 (2010)Cited in1Mapped to99+
Structure Determination of the Transactivation Domain of p53 in Complex with S100A4Using Annexin A2 as a Crystallization Chaperone.Ecsedi P., Gogl G., Hof H., Kiss B., Harmat V., Nyitray L.View abstractCited forX-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 17-56, INTERACTION WITH S100A4CategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCStructure 28:943-953.e4 (2020)Cited in2
Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability.Nikolova P.V., Henckel J., Lane D.P., Fersht A.R.View abstractCategoriesStructureSourcePDB: 1UOLPubMedEurope PMCProc Natl Acad Sci U S A 95:14675-14680 (1998)Mapped to1
Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template.Mittl P.R., Chene P., Grutter M.G.View abstractCategoriesStructureSourcePDB: 1AIEPubMedEurope PMCActa Crystallogr D Biol Crystallogr 54:86-89 (1998)Mapped to1
Refined solution structure of the oligomerization domain of the tumour suppressor p53.Clore G.M., Ernst J., Clubb R., Omichinski J.G., Kennedy W.M., Sakaguchi K., Appella E., Gronenborn A.M.View abstractCategoriesStructureSourcePDB: 1SAE, PDB: 1SAF, PDB: 1SAK, PDB: 1SALPubMedEurope PMCNat Struct Biol 2:321-333 (1995)Mapped to1
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.Balourdas D.I., Markl A.M., Kramer A., Settanni G., Joerger A.C.View abstractCategoriesStructureSourcePDB: 8QWK, PDB: 8QWL, PDB: 8QWM, PDB: 8QWN, PDB: 8QWO, PDB: 8QWPPubMedEurope PMCCell Death Dis 15:408-408 (2024)Mapped to1
Structure of the p53 degradation complex from HPV16.Wang J.C.K., Baddock H.T., Mafi A., Foe I.T., Bratkowski M., Lin T.Y., Jensvold Z.D., Preciado Lopez M., Stokoe D.[...], Nile A.H.View abstractCategoriesStructureSourcePDB: 8GCRPubMedEurope PMCNat Commun 15:1842-1842 (2024)Mapped to4