P04408 · KITH_SHV1
- ProteinThymidine kinase
- GeneTK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids361 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Catalytic activity
- thymidine + ATP = dTMP + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17-24 | ATP (UniProtKB | ChEBI) | |||
Active site | 46 | Proton acceptor | |||
Binding site | 64 | substrate | |||
Binding site | 88 | substrate | |||
Binding site | 184 | ATP (UniProtKB | ChEBI) | |||
Binding site | 190 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | thymidine kinase activity | |
Biological Process | DNA biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | TMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThymidine kinase
- EC number
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus saimiriinealpha1
- Virus hosts
Accessions
- Primary accessionP04408
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000175078 | 1-361 | Thymidine kinase | ||
Expression
Keywords
- Developmental stage
Interaction
Subunit
Homodimer.
Sequence
- Sequence statusComplete
- Length361
- Mass (Da)39,458
- Last updated1995-11-01 v2
- MD5 Checksum374FF7BB26CCE38BF2A84FDB053A137A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
K02122 EMBL· GenBank· DDBJ | AAA67102.1 EMBL· GenBank· DDBJ | Genomic DNA |