P04363 · KITH_MONPZ

Function

function

Phosphorylates thymidine and thymidine analogs, such as azidothymidine (AZT). Part of the salvage pathway for pyrimidine deoxyribonucleotide synthesis.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-18ATP (UniProtKB | ChEBI)
Active site83Proton acceptor
Binding site113substrate
Binding site138Zn2+ (UniProtKB | ChEBI)
Binding site141Zn2+ (UniProtKB | ChEBI)
Binding site157-161substrate
Binding site170Zn2+ (UniProtKB | ChEBI)
Binding site173Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionthymidine kinase activity
Biological ProcessDNA biosynthetic process
Biological Processthymidine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      OPG101
    • Synonyms
      TK
    • ORF names
      L2R

Organism names

Accessions

  • Primary accession
    P04363
  • Secondary accessions
    • Q8V4Z6

Proteomes

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001749311-177Thymidine kinase
Disulfide bond170Interchain (with C-173)
Disulfide bond173Interchain (with C-170)

Keywords

Interaction

Subunit

Homotetramer. Two molecules of substrate bind to each enzyme tetramer.

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the thymidine kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    177
  • Mass (Da)
    19,990
  • Last updated
    2002-08-02 v2
  • Checksum
    8A7BAAB3238C91D2
MNGGHIQLIIGPMLSGKSTELIRRVRRYQIAQYKCVTIKYSNDNRYGTGLWTHDKNNFAALEVTKLCDVLEAITDFSVIGIDEGQFFPDIVEFCERMANEGKIVIVAALDGTFQRRPFNNILNLIPLSEMVVKLTAVCMKCFKEASFSKRLGAETEIEIIGGNDMYQSVCRKCYIDS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict14in Ref. 1; AAA80529
Sequence conflict90in Ref. 1; AAA80529
Sequence conflict153in Ref. 1; AAA80529

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
K02025
EMBL· GenBank· DDBJ
AAA80529.1
EMBL· GenBank· DDBJ
Genomic DNA
AF380138
EMBL· GenBank· DDBJ
AAL40544.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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