P04223 · HA1K_MOUSE

  • Protein
    H-2 class I histocompatibility antigen, K-K alpha chain
  • Gene
    H2-K1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in the presentation of foreign antigens to the immune system.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Cellular Componentlumenal side of endoplasmic reticulum membrane
Cellular ComponentMHC class I protein complex
Cellular Componentphagocytic vesicle membrane
Molecular Functionbeta-2-microglobulin binding
Molecular Functionpeptide antigen binding
Molecular Functionpeptide binding
Molecular Functionprotein-containing complex binding
Molecular Functionsignaling receptor binding
Biological Processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
Biological Processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
Biological Processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
Biological Processantigen processing and presentation of exogenous peptide antigen via MHC class I
Biological Processdefense response to bacterium
Biological Processimmune response
Biological Processinner ear development
Biological Processnegative regulation of neuron projection development
Biological Processpositive regulation of T cell mediated cytotoxicity
Biological ProcessT cell mediated cytotoxicity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    H-2 class I histocompatibility antigen, K-K alpha chain
  • Short names
    H-2K(K)

Gene names

    • Name
      H2-K1
    • Synonyms
      H2-K

Organism names

  • Taxonomic identifier
  • Strains
    • C3H/HeJ
    • C3H/HeN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P04223
  • Secondary accessions
    • O19459
    • Q31165
    • Q31192
    • Q95458

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain22-305Extracellular
Transmembrane306-328Helical
Topological domain329-369Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant173

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000001893022-369H-2 class I histocompatibility antigen, K-K alpha chain
Glycosylation107N-linked (GlcNAc...) asparagine
Disulfide bond122↔185
Glycosylation197N-linked (GlcNAc...) asparagine
Disulfide bond224↔280
Modified residue351Phosphoserine
Modified residue351In isoform P04223-2; Phosphoserine
Modified residue354Phosphoserine
Modified residue354In isoform P04223-2; Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region22-111Alpha-1
Region112-203Alpha-2
Region204-295Alpha-3
Domain206-294Ig-like C1-type
Region296-305Connecting peptide

Sequence similarities

Belongs to the MHC class I family.

Keywords

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P04223-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    369
  • Mass (Da)
    41,646
  • Last updated
    1987-03-20 v1
  • Checksum
    9533CF96600A595C
MAPCMLLLLLAAALAPTQTRAGPHSLRYFHTAVSRPGLGKPRFISVGYVDDTQFVRFDSDAENPRYEPRVRWMEQVEPEYWERNTQIAKGNEQIFRVNLRTALRYYNQSAGGSHTFQRMYGCEVGSDWRLLRGYEQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGDAERDRAYLEGTCVEWLRRYLQLGNATLPRTDSPKAHVTRHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNTVIIAVLVVLGAAIVTGAVVAFVMKMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA

P04223-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P01901HA1B_MOUSEH2-K1369
P14428HA1Q_MOUSEH2-K1328
A0A494B9G2A0A494B9G2_MOUSEH2-K1130
A0A494B9G8A0A494B9G8_MOUSEH2-K1190
A0A0B4J1G3A0A0B4J1G3_MOUSEH2-K1187
A0A494BAT0A0A494BAT0_MOUSEH2-K1356
A0A494BA33A0A494BA33_MOUSEH2-K1355
P03991HA1W_MOUSEH2-K1368
P01902HA1D_MOUSEH2-K1368
G3UXW2G3UXW2_MOUSEH2-K1289
Q3TH01Q3TH01_MOUSEH2-K1360

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict50in Ref. 5; AAA39654
Sequence conflict98in Ref. 2; AAA53202
Alternative sequenceVSP_011855360-369in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X01652
EMBL· GenBank· DDBJ
CAA25816.1
EMBL· GenBank· DDBJ
Genomic DNA
M18525
EMBL· GenBank· DDBJ
AAA53202.1
EMBL· GenBank· DDBJ
Genomic DNA
U47330
EMBL· GenBank· DDBJ
AAB17608.1
EMBL· GenBank· DDBJ
mRNA
M18964
EMBL· GenBank· DDBJ
AAA39568.1
EMBL· GenBank· DDBJ
Genomic DNA
M11975
EMBL· GenBank· DDBJ
AAA39654.1
EMBL· GenBank· DDBJ
mRNA
M34932
EMBL· GenBank· DDBJ
AAA39596.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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