P04223 · HA1K_MOUSE
- ProteinH-2 class I histocompatibility antigen, K-K alpha chain
- GeneH2-K1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids369 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the presentation of foreign antigens to the immune system.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameH-2 class I histocompatibility antigen, K-K alpha chain
- Short namesH-2K(K)
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP04223
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 22-305 | Extracellular | ||||
Sequence: GPHSLRYFHTAVSRPGLGKPRFISVGYVDDTQFVRFDSDAENPRYEPRVRWMEQVEPEYWERNTQIAKGNEQIFRVNLRTALRYYNQSAGGSHTFQRMYGCEVGSDWRLLRGYEQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGDAERDRAYLEGTCVEWLRRYLQLGNATLPRTDSPKAHVTRHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNT | ||||||
Transmembrane | 306-328 | Helical | ||||
Sequence: VIIAVLVVLGAAIVTGAVVAFVM | ||||||
Topological domain | 329-369 | Cytoplasmic | ||||
Sequence: KMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 173 | |||||
Sequence: D → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MAPCMLLLLLAAALAPTQTRA | ||||||
Chain | PRO_0000018930 | 22-369 | H-2 class I histocompatibility antigen, K-K alpha chain | |||
Sequence: GPHSLRYFHTAVSRPGLGKPRFISVGYVDDTQFVRFDSDAENPRYEPRVRWMEQVEPEYWERNTQIAKGNEQIFRVNLRTALRYYNQSAGGSHTFQRMYGCEVGSDWRLLRGYEQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGDAERDRAYLEGTCVEWLRRYLQLGNATLPRTDSPKAHVTRHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNTVIIAVLVVLGAAIVTGAVVAFVMKMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA | ||||||
Glycosylation | 107 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 122↔185 | |||||
Sequence: CEVGSDWRLLRGYEQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGDAERDRAYLEGTC | ||||||
Glycosylation | 197 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 224↔280 | |||||
Sequence: CWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTC | ||||||
Modified residue | 351 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 351 | In isoform P04223-2; Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 354 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 354 | In isoform P04223-2; Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 22-111 | Alpha-1 | ||||
Sequence: GPHSLRYFHTAVSRPGLGKPRFISVGYVDDTQFVRFDSDAENPRYEPRVRWMEQVEPEYWERNTQIAKGNEQIFRVNLRTALRYYNQSAG | ||||||
Region | 112-203 | Alpha-2 | ||||
Sequence: GSHTFQRMYGCEVGSDWRLLRGYEQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGDAERDRAYLEGTCVEWLRRYLQLGNATLPRT | ||||||
Region | 204-295 | Alpha-3 | ||||
Sequence: DSPKAHVTRHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRW | ||||||
Domain | 206-294 | Ig-like C1-type | ||||
Sequence: PKAHVTRHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLR | ||||||
Region | 296-305 | Connecting peptide | ||||
Sequence: EPPPSTVSNT |
Sequence similarities
Belongs to the MHC class I family.
Keywords
- Domain
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P04223-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length369
- Mass (Da)41,646
- Last updated1987-03-20 v1
- Checksum9533CF96600A595C
P04223-2
- Name2
- Differences from canonical
- 360-369: VMVHDPHSLA → A
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P01901 | HA1B_MOUSE | H2-K1 | 369 | ||
P14428 | HA1Q_MOUSE | H2-K1 | 328 | ||
A0A494B9G2 | A0A494B9G2_MOUSE | H2-K1 | 130 | ||
A0A494B9G8 | A0A494B9G8_MOUSE | H2-K1 | 190 | ||
A0A0B4J1G3 | A0A0B4J1G3_MOUSE | H2-K1 | 187 | ||
A0A494BAT0 | A0A494BAT0_MOUSE | H2-K1 | 356 | ||
A0A494BA33 | A0A494BA33_MOUSE | H2-K1 | 355 | ||
P03991 | HA1W_MOUSE | H2-K1 | 368 | ||
P01902 | HA1D_MOUSE | H2-K1 | 368 | ||
G3UXW2 | G3UXW2_MOUSE | H2-K1 | 289 | ||
Q3TH01 | Q3TH01_MOUSE | H2-K1 | 360 |
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 50 | in Ref. 5; AAA39654 | ||||
Sequence: D → E | ||||||
Sequence conflict | 98 | in Ref. 2; AAA53202 | ||||
Sequence: N → S | ||||||
Alternative sequence | VSP_011855 | 360-369 | in isoform 2 | |||
Sequence: VMVHDPHSLA → A |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X01652 EMBL· GenBank· DDBJ | CAA25816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M18525 EMBL· GenBank· DDBJ | AAA53202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U47330 EMBL· GenBank· DDBJ | AAB17608.1 EMBL· GenBank· DDBJ | mRNA | ||
M18964 EMBL· GenBank· DDBJ | AAA39568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M11975 EMBL· GenBank· DDBJ | AAA39654.1 EMBL· GenBank· DDBJ | mRNA | ||
M34932 EMBL· GenBank· DDBJ | AAA39596.1 EMBL· GenBank· DDBJ | mRNA |