P04135 · VME1_CVPPU

Function

function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Caution

The C-terminus of some M molecules seems to be exposed on the external surface of the virion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell Golgi membrane
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionstructural constituent of virion

Names & Taxonomy

Protein names

  • Recommended name
    Membrane protein
  • Short names
    M protein
  • Alternative names
    • E1 glycoprotein
    • Matrix glycoprotein
    • Membrane glycoprotein

Gene names

    • Name
      M
    • ORF names
      5

Organism names

Accessions

  • Primary accession
    P04135

Proteomes

Subcellular Location

Virion membrane
; Multi-pass membrane protein
Host Golgi apparatus membrane
; Multi-pass membrane protein
Note: Largely embedded in the lipid bilayer.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain18-47Virion surface
Transmembrane48-68Helical
Topological domain69-77Intravirion
Transmembrane78-98Helical
Topological domain99-112Virion surface
Transmembrane113-133Helical
Topological domain134-262Intravirion

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis33In DM49-3; reduces production of alpha-interferon by the host organism.
Mutagenesis33In DM25-3/49-12; does not affect production of alpha-interferon by the host organism.
Mutagenesis34In DM49-4; abolishes production of alpha-interferon by the host organism.

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000371551-262Membrane protein
Glycosylation32N-linked (GlcNAc...) asparagine; by host

Keywords

PTM databases

Interaction

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO P04135EIF4A2 A6M9304EBI-25568430, EBI-25568629

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region237-252Interaction with N protein

Sequence similarities

Belongs to the alphacoronaviruses M protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    262
  • Mass (Da)
    29,569
  • Last updated
    1989-10-01 v2
  • Checksum
    56D6441D2ABBABF4
MKILLILACVIACACGERYCAMKSDTDLSCRNSTASDCESCFNGGDLIWHLANWNFSWSIILIVFITVLQYGRPQFSWFVYGIKMLIMWLLWPVVLALTIFNAYSEYQVSRYVMFGFSIAGAIVTFVLWIMYFVRSIQLYRRTKSWWSFNPETKAILCVSALGRSYVLPLEGVPTGVTLTLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKKLKASSATGWAYYVKSKAGDYSTEARTDNLSEQEKLLHMV

Sequence caution

The sequence AAA47912.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict80in Ref. 1; AAA47912
Sequence conflict144in Ref. 2; CAA29091
Sequence conflict195in Ref. 2 and 3
Sequence conflict197in Ref. 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M21627
EMBL· GenBank· DDBJ
AAA47912.1
EMBL· GenBank· DDBJ
Genomic RNA Different initiation
X05598
EMBL· GenBank· DDBJ
CAA29091.1
EMBL· GenBank· DDBJ
Genomic RNA
X06371
EMBL· GenBank· DDBJ
CAA29673.1
EMBL· GenBank· DDBJ
Genomic RNA
AJ271965
EMBL· GenBank· DDBJ
CAB91149.2
EMBL· GenBank· DDBJ
Genomic RNA
M14878
EMBL· GenBank· DDBJ
AAA47914.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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