P04118 · COL_HUMAN
- ProteinColipase
- GeneCLPS
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids112 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | enzyme activator activity | |
Molecular Function | lipase binding | |
Biological Process | digestion | |
Biological Process | lipid catabolic process | |
Biological Process | lipid metabolic process | |
Biological Process | response to bacterium | |
Biological Process | response to food |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameColipase
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP04118
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_053040 | 8 | in dbSNP:rs2766597 | |||
Sequence: L → P | ||||||
Natural variant | VAR_047105 | 109 | in dbSNP:rs41270082 | |||
Sequence: R → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 142 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, propeptide, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MEKILILLLVALSVAYA | ||||||
Propeptide | PRO_0000005696 | 18-22 | Enterostatin, activation peptide | |||
Sequence: APGPR | ||||||
Chain | PRO_0000005697 | 23-112 | Colipase | |||
Sequence: GIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ | ||||||
Disulfide bond | 34↔45 | |||||
Sequence: CMNSAQCKSNCC | ||||||
Disulfide bond | 40↔56 | |||||
Sequence: CKSNCCQHSSALGLARC | ||||||
Disulfide bond | 44↔78 | |||||
Sequence: CCQHSSALGLARCTSMASENSECSVKTLYGIYYKC | ||||||
Disulfide bond | 66↔86 | |||||
Sequence: CSVKTLYGIYYKCPCERGLTC | ||||||
Disulfide bond | 80↔104 | |||||
Sequence: CERGLTCEGDKTIVGSITNTNFGIC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed by the pancreas.
Gene expression databases
Organism-specific databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length112
- Mass (Da)11,954
- Last updated1990-04-01 v2
- Checksum772872EBBE7C4DF8
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087X0Q7 | A0A087X0Q7_HUMAN | CLPS | 71 | ||
A0A087WZW1 | A0A087WZW1_HUMAN | CLPS | 98 |
Polymorphism
Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J02883 EMBL· GenBank· DDBJ | AAA52054.1 EMBL· GenBank· DDBJ | mRNA | ||
M95529 EMBL· GenBank· DDBJ | AAB05818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT006812 EMBL· GenBank· DDBJ | AAP35458.1 EMBL· GenBank· DDBJ | mRNA | ||
AL157823 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471081 EMBL· GenBank· DDBJ | EAX03850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC007061 EMBL· GenBank· DDBJ | AAH07061.1 EMBL· GenBank· DDBJ | mRNA | ||
BC017897 EMBL· GenBank· DDBJ | AAH17897.1 EMBL· GenBank· DDBJ | mRNA | ||
AY780648 EMBL· GenBank· DDBJ | AAV35728.1 EMBL· GenBank· DDBJ | mRNA |