P04118 · COL_HUMAN

  • Protein
    Colipase
  • Gene
    CLPS
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionenzyme activator activity
Molecular Functionlipase binding
Biological Processdigestion
Biological Processlipid catabolic process
Biological Processlipid metabolic process
Biological Processresponse to bacterium
Biological Processresponse to food

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Colipase

Gene names

    • Name
      CLPS

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P04118
  • Secondary accessions
    • Q5T9G7
    • Q5U809

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0530408in dbSNP:rs2766597
Natural variantVAR_047105109in dbSNP:rs41270082

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 142 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
PropeptidePRO_000000569618-22Enterostatin, activation peptide
ChainPRO_000000569723-112Colipase
Disulfide bond34↔45
Disulfide bond40↔56
Disulfide bond44↔78
Disulfide bond66↔86
Disulfide bond80↔104

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed by the pancreas.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the colipase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    112
  • Mass (Da)
    11,954
  • Last updated
    1990-04-01 v2
  • Checksum
    772872EBBE7C4DF8
MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087X0Q7A0A087X0Q7_HUMANCLPS71
A0A087WZW1A0A087WZW1_HUMANCLPS98

Polymorphism

Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J02883
EMBL· GenBank· DDBJ
AAA52054.1
EMBL· GenBank· DDBJ
mRNA
M95529
EMBL· GenBank· DDBJ
AAB05818.1
EMBL· GenBank· DDBJ
Genomic DNA
BT006812
EMBL· GenBank· DDBJ
AAP35458.1
EMBL· GenBank· DDBJ
mRNA
AL157823
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471081
EMBL· GenBank· DDBJ
EAX03850.1
EMBL· GenBank· DDBJ
Genomic DNA
BC007061
EMBL· GenBank· DDBJ
AAH07061.1
EMBL· GenBank· DDBJ
mRNA
BC017897
EMBL· GenBank· DDBJ
AAH17897.1
EMBL· GenBank· DDBJ
mRNA
AY780648
EMBL· GenBank· DDBJ
AAV35728.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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