P03929 · ATP8_BOVIN

  • Protein
    ATP synthase protein 8
  • Gene
    MT-ATP8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentmitochondrion
Cellular Componentproton-transporting ATP synthase complex
Cellular Componentproton-transporting ATP synthase complex, coupling factor F(o)
Molecular Functionproton transmembrane transporter activity
Biological Processproton motive force-driven ATP synthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP synthase protein 8
  • Alternative names
    • A6L
    • F-ATPase subunit 8

Gene names

    • Name
      MT-ATP8
    • Synonyms
      ATP8, ATPASE8, MTATP8

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 65
    • 66
    • Hereford
    • D
    • F
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    P03929

Proteomes

    • Identifier
    • Component
      Mitochondrion MT, Unassembled WGS sequence

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane8-24Helical

Keywords

PTM/Processing

Features

Showing features for modified residue, chain.

Type
IDPosition(s)Description
Modified residue1N-formylmethionine
ChainPRO_00001954951-66ATP synthase protein 8
Modified residue54N6-acetyllysine; alternate
Modified residue54N6-succinyllysine; alternate
Modified residue57N6-acetyllysine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ. Interacts with PRICKLE3 (By similarity).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ATPase protein 8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    66
  • Mass (Da)
    7,937
  • Last updated
    1986-07-21 v1
  • Checksum
    0DED46ADEF5D8BDE
MPQLDTSTWLTMILSMFLTLFIIFQLKVSKHNFYHNPELTPTKMLKQNTPWETKWTKIYLPLLLPL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
V00654
EMBL· GenBank· DDBJ
CAA24001.1
EMBL· GenBank· DDBJ
Genomic DNA
AF490528
EMBL· GenBank· DDBJ
AAM08333.1
EMBL· GenBank· DDBJ
Genomic DNA
AF490529
EMBL· GenBank· DDBJ
AAM08346.1
EMBL· GenBank· DDBJ
Genomic DNA
AF493541
EMBL· GenBank· DDBJ
AAM12793.1
EMBL· GenBank· DDBJ
Genomic DNA
AF493542
EMBL· GenBank· DDBJ
AAM12806.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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