P03899 · NU3M_MOUSE

  • Protein
    NADH-ubiquinone oxidoreductase chain 3
  • Gene
    mt-Nd3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial respiratory chain complex I
Cellular Componentmitochondrion
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processaerobic respiration
Biological Processcellular response to glucocorticoid stimulus
Biological Processmitochondrial electron transport, NADH to ubiquinone
Biological Processproton motive force-driven mitochondrial ATP synthesis
Biological Processresponse to hormone
Biological Processresponse to light intensity
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 3
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 3

Gene names

    • Name
      mt-Nd3
    • Synonyms
      Nd3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • AKR/J
    • C3H/He
    • SAMP1
    • SAMP8
    • SAMR1
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P03899
  • Secondary accessions
    • Q35039
    • Q35040
    • Q9MD73

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical
Transmembrane55-75Helical
Transmembrane86-106Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001177651-115NADH-ubiquinone oxidoreductase chain 3

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
View interactors in UniProtKB
View CPX-266 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the complex I subunit 3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    115
  • Mass (Da)
    13,219
  • Last updated
    2001-11-16 v3
  • Checksum
    6925F293601CB391
MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPTSSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGLAYEWTQKGLEWTE

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict16in Ref. 2; AAA19255
Sequence conflict33in Ref. 1; AAB48651/CAA24086

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J01420
EMBL· GenBank· DDBJ
AAB48651.1
EMBL· GenBank· DDBJ
Genomic DNA
V00711
EMBL· GenBank· DDBJ
CAA24086.1
EMBL· GenBank· DDBJ
Genomic DNA
U09637
EMBL· GenBank· DDBJ
AAA19254.2
EMBL· GenBank· DDBJ
Genomic DNA
U09638
EMBL· GenBank· DDBJ
AAA19255.2
EMBL· GenBank· DDBJ
Genomic DNA
AB042432
EMBL· GenBank· DDBJ
BAA95623.1
EMBL· GenBank· DDBJ
Genomic DNA
AB042523
EMBL· GenBank· DDBJ
BAA95660.1
EMBL· GenBank· DDBJ
Genomic DNA
AB042524
EMBL· GenBank· DDBJ
BAA95647.1
EMBL· GenBank· DDBJ
Genomic DNA
AB042809
EMBL· GenBank· DDBJ
BAA95802.1
EMBL· GenBank· DDBJ
Genomic DNA
AB049357
EMBL· GenBank· DDBJ
BAB13808.1
EMBL· GenBank· DDBJ
Genomic DNA
AY172335
EMBL· GenBank· DDBJ
AAN85129.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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