Nucleotide sequences of influenza virus segments 1 and 3 reveal mosaic structure of a small viral RNA segment.Fields S., Winter G.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC RNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 28:303-313 (1982)Cited in4
Plasmid-only rescue of influenza A virus vaccine candidates.Schickli J.H., Flandorfer A., Nakaya T., Martinez-Sobrido L., Garcia-Sastre A., Palese P.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC RNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPhilos. Trans. R. Soc. Lond., B, Biol. Sci. 356:1965-1973 (2001)Cited in121
Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments.de Wit E., Spronken M.I.J., Bestebroer T.M., Rimmelzwaan G.F., Osterhaus A.D.M.E., Fouchier R.A.M.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC RNA], REVERSE GENETICSCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCVirus Res. 103:155-161 (2004)Cited in1312
The NIAID influenza genome sequencing project.Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M., Sparenborg J., Groveman L.[...], Tatusova T.Cited forNUCLEOTIDE SEQUENCE [GENOMIC RNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (MAR-2006)Cited in37
The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex.Fodor E., Smith M.View abstractCited forSUBCELLULAR LOCATIONStrainA/WSN/33CategoriesSubcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Virol. 78:9144-9153 (2004)Cited in2
Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses.Carr S.M., Carnero E., Garcia-Sastre A., Brownlee G.G., Fodor E.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONStrainA/WSN/33CategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCVirology 344:492-508 (2006)Cited in2
Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication.Deng T., Sharps J.L., Brownlee G.G.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Gen. Virol. 87:3373-3377 (2006)Cited in1
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.Graef K.M., Vreede F.T., Lau Y.F., McCall A.W., Carr S.M., Subbarao K., Fodor E.View abstractCited forFUNCTION, INTERACTION WITH HOST MAVS, SUBCELLULAR LOCATIONCategoriesFunction, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Virol. 84:8433-8445 (2010)Cited in1Mapped to5
Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.Ng A.K., Chan W.H., Choi S.T., Lam M.K., Lau K.F., Chan P.K., Au S.W., Fodor E., Shaw P.C.View abstractCited forFUNCTION, INTERACTION WITH NUCLEOPROTEIN NPCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS ONE 7:E36415-E36415 (2012)Cited in1
Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins.Patel D., Schultz L.W., Umland T.C.View abstractCited forFUNCTION, INTERACTION WITH HOST MAVSStrainA/WSN/33CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCVirus Res. 172:75-80 (2013)Cited in1Mapped to1
An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2.Gui X., Li R., Zhang X., Shen C., Yu H., Guo X., Kang Y., Chen J., Chen H.[...], Xia N.View abstractCited forFUNCTION, INTERACTION WITH NUCLEOPROTEIN NPStrainA/WSN/193CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCVirology 464:11-20 (2014)Cited in1
Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.Wang L., Fu B., Li W., Patil G., Liu L., Dorf M.E., Li S.View abstractCited forINTERACTION WITH PB1CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Commun. 8:13876-13876 (2017)Cited in8Mapped to3
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue.Kuzuhara T., Kise D., Yoshida H., Horita T., Murazaki Y., Nishimura A., Echigo N., Utsunomiya H., Tsuge H.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 535-759CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 284:6855-6860 (2009)Cited in1
Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus.Liu Y., Qin K., Meng G., Zhang J., Zhou J., Zhao G., Luo M., Zheng X.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.32 ANGSTROMS) OF 318-483CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 288:11013-11023 (2013)Cited in11Mapped to1
Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus.Tsurumura T., Qiu H., Yoshida T., Tsumori Y., Hatakeyama D., Kuzuhara T., Tsuge H.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 318-484CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS ONE 8:E82020-E82020 (2013)Cited in1
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.Tsurumura T., Qiu H., Yoshida T., Tsumori Y., Tsuge H.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 318-484CategoriesStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCActa Crystallogr. F 70:72-75 (2014)Cited in1
Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication.Sun H., Tu S., Luo D., Dai C., Jin M., Chen H., Zou J., Zhou H.View abstractAnnotationProtein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication.CategoriesFunctionSourceGeneRif: 956536PubMedEurope PMCJ Med Virol 95:e29171-e29171 (2023)Mapped to4
Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors.Zong K., Xu L., Hou Y., Zhang Q., Che J., Zhao L., Li X.View abstractAnnotationVirtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors.CategoriesFunctionSourceGeneRif: 956536PubMedEurope PMCMolecules 26:6944-6944 (2021)Mapped to1
Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.Soh Y.Q.S., Malone K.D., Eguia R.T., Bloom J.D.View abstractAnnotationComprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.CategoriesPhenotypes & VariantsSourceGeneRif: 956536PubMedEurope PMCViruses 13:1196-1196 (2021)Mapped to1
CD8<sup>+</sup> T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.Hensen L., Illing P.T., Bridie Clemens E., Nguyen T.H.O., Koutsakos M., van de Sandt C.E., Mifsud N.A., Nguyen A.T., Szeto C.[...], Kedzierska K.View abstractCategoriesStructureSourcePDB: 7JYW, PDB: 7JYXPubMedEurope PMCNat Commun 12:2931-2931 (2021)Cited in2Mapped to3
A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.Cox A., Schmierer J., D'Angelo J., Smith A., Levenson D., Treanor J., Kim B., Dewhurst S.View abstractAnnotationA Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 956536PubMedEurope PMCViruses 12:E1246-E1246 (2020)Mapped to2
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.Sun N., Jiang L., Ye M., Wang Y., Wang G., Wan X., Zhao Y., Wen X., Liang L.[...], Li C.View abstractAnnotationTRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.CategoriesPTM / ProcessingSourceGeneRif: 956536PubMedEurope PMCProtein Cell 11:894-914 (2020)Cited in3Mapped to9
Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases.Karim M., Biquand E., Declercq M., Jacob Y., van der Werf S., Demeret C.View abstractAnnotationNonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases.CategoriesPTM / ProcessingSourceGeneRif: 956536PubMedEurope PMCmBio 11:e00305-20 (2020)Mapped to1
Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice.Ivan F.X., Kwoh C.K.View abstractAnnotationThe study confirmed the polygenic nature of Influenza A virus virulence with several sites in PB2 playing more dominant role (meta-analysis).CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 956536PubMedEurope PMCBMC Genomics 20:973-973 (2019)Mapped to1
The interaction of cellular protein ANP32A with influenza A virus polymerase component PB2 promotes vRNA synthesis.Wei X., Liu Z., Wang J., Yang R., Yang J., Guo Y., Tan H., Chen H., Liu Q., Liu L.View abstractAnnotationThe C-terminal portion of ANP32A and the middle domains (residues 307-534) of PB2 were required for PB2-ANP32A interaction.CategoriesInteractionSourceGeneRif: 956536PubMedEurope PMCArch. Virol. 164:787-798 (2019)Cited in2Mapped to5