P03353 · PRO_HTLV2
- ProteinGag-Pro polyprotein
- Genegag-pro
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids602 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Gag-Pro polyprotein
Matrix protein p19
Capsid protein p24
Nucleocapsid protein p15-pro
Protease
Miscellaneous
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 136-137 | Cleavage; by viral protease | ||||
Sequence: FP | ||||||
Site | 350-351 | Cleavage; by viral protease | ||||
Sequence: LV | ||||||
Site | 446-447 | Cleavage; by viral protease | ||||
Sequence: LP | ||||||
Active site | 478 | Protease; shared with dimeric partner | ||||
Sequence: D | ||||||
Site | 571-572 | Cleavage; by viral protease | ||||
Sequence: LP | ||||||
Site | 579-580 | Cleavage; by viral protease | ||||
Sequence: IG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | viral nucleocapsid | |
Molecular Function | aspartic-type endopeptidase activity | |
Molecular Function | nucleic acid binding | |
Molecular Function | structural molecule activity | |
Molecular Function | zinc ion binding | |
Biological Process | proteolysis | |
Biological Process | symbiont-mediated suppression of host gene expression | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGag-Pro polyprotein
- Alternative names
- Cleaved into 6 chains
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Deltaretrovirus > Primate T-lymphotropic virus 2
- Virus hosts
Accessions
- Primary accessionP03353
Proteomes
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain, peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed; by host | ||||
Sequence: M | ||||||
Lipidation | 2 | N-myristoyl glycine; by host | ||||
Sequence: G | ||||||
Chain | PRO_0000259810 | 2-136 | Matrix protein p19 | |||
Sequence: GQIHGLSPTPIPKAPRGLSTHHWLNFLQAAYRLQPRPSDFDFQQLRRFLKLALKTPIWLNPIDYSLLASLIPKGYPGRVVEIINILVKNQVSPSAPAAPVPTPICPTTTPPPPPPPSPEAHVPPPYVEPTTTQCF | ||||||
Chain | PRO_0000259809 | 2-602 | Gag-Pro polyprotein | |||
Sequence: GQIHGLSPTPIPKAPRGLSTHHWLNFLQAAYRLQPRPSDFDFQQLRRFLKLALKTPIWLNPIDYSLLASLIPKGYPGRVVEIINILVKNQVSPSAPAAPVPTPICPTTTPPPPPPPSPEAHVPPPYVEPTTTQCFPILHPPGAPSAHRPWQMKDLQAIKQEVSSSALGSPQFMQTLRLAVQQFDPTAKDLQDLLQYLCSSLVVSLHHQQLNTLITEAETRGMTGYNPMAGPLRMQANNPAQQGLRREYQNLWLAAFSTLPGNTRDPSWAAILQGLEEPYCAFVERLNVALDNGLPEGTPKEPILRSLAYSNANKECQKILQARGHTNSPLGEMLRTCQAWTPKDKTKVLVVQPRRPPPTQPCFRCGKVGHWSRDCTQPRPPPGPCPLCQDPSHWKRDCPQLKPPQEEGEPLLLDLPSTSGTTEEKNLLKGGDLISPHPDQDISILPLIPLRQQQQPILGVRISVMGQTPQPTQALLDTGADLTVIPQTLVPGPVKLHDTLILGASGQTNTQFKLLQTPLHIFLPFRRSPVILSSCLLDTHNKWTIIGRDALQQCQGLLYLPDDPSPHQLLPIATPNTIGLEHLPPPPQVDQFPLNLSASRP | ||||||
Chain | PRO_0000259811 | 137-350 | Capsid protein p24 | |||
Sequence: PILHPPGAPSAHRPWQMKDLQAIKQEVSSSALGSPQFMQTLRLAVQQFDPTAKDLQDLLQYLCSSLVVSLHHQQLNTLITEAETRGMTGYNPMAGPLRMQANNPAQQGLRREYQNLWLAAFSTLPGNTRDPSWAAILQGLEEPYCAFVERLNVALDNGLPEGTPKEPILRSLAYSNANKECQKILQARGHTNSPLGEMLRTCQAWTPKDKTKVL | ||||||
Chain | PRO_0000259812 | 351-446 | Nucleocapsid protein p15-pro | |||
Sequence: VVQPRRPPPTQPCFRCGKVGHWSRDCTQPRPPPGPCPLCQDPSHWKRDCPQLKPPQEEGEPLLLDLPSTSGTTEEKNLLKGGDLISPHPDQDISIL | ||||||
Chain | PRO_0000199535 | 447-571 | Protease | |||
Sequence: PLIPLRQQQQPILGVRISVMGQTPQPTQALLDTGADLTVIPQTLVPGPVKLHDTLILGASGQTNTQFKLLQTPLHIFLPFRRSPVILSSCLLDTHNKWTIIGRDALQQCQGLLYLPDDPSPHQLL | ||||||
Peptide | PRO_0000259813 | 572-579 | p1 | |||
Sequence: PIATPNTI | ||||||
Chain | PRO_0000259814 | 580-602 | Transframe peptide | |||
Sequence: GLEHLPPPPQVDQFPLNLSASRP |
Post-translational modification
Gag-Pro polyprotein
Matrix protein p19
Gag-Pro polyprotein
Keywords
- PTM
Interaction
Subunit
Gag-Pro polyprotein
Matrix protein p19
Family & Domains
Features
Showing features for motif, region, compositional bias, zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 94-97 | PTAP/PSAP motif | ||||
Sequence: PSAP | ||||||
Region | 94-121 | Disordered | ||||
Sequence: PSAPAAPVPTPICPTTTPPPPPPPSPEA | ||||||
Compositional bias | 97-121 | Pro residues | ||||
Sequence: PAAPVPTPICPTTTPPPPPPPSPEA | ||||||
Motif | 124-127 | PPXY motif | ||||
Sequence: PPPY | ||||||
Zinc finger | 361-378 | CCHC-type 1 | ||||
Sequence: QPCFRCGKVGHWSRDCTQ | ||||||
Zinc finger | 384-401 | CCHC-type 2 | ||||
Sequence: GPCPLCQDPSHWKRDCPQ | ||||||
Region | 399-425 | Disordered | ||||
Sequence: CPQLKPPQEEGEPLLLDLPSTSGTTEE | ||||||
Domain | 473-551 | Peptidase A2 | ||||
Sequence: TQALLDTGADLTVIPQTLVPGPVKLHDTLILGASGQTNTQFKLLQTPLHIFLPFRRSPVILSSCLLDTHNKWTIIGRDA | ||||||
Region | 582-602 | Disordered | ||||
Sequence: EHLPPPPQVDQFPLNLSASRP |
Domain
Capsid protein p24
Gag-Pro polyprotein
Keywords
- Domain
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Ribosomal frameshifting. This strategy of translation probably allows the virus to modulate the quantity of each viral protein.
P03353-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameGag-Pro polyprotein
- NoteProduced by -1 ribosomal frameshifting at the gag-pro genes boundary.
- Length602
- Mass (Da)66,435
- Last updated2007-01-23 v3
- Checksum15627B078EFAC16E
P03346-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameGag polyprotein
P03363-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameGag-Pro-Pol polyprotein
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 97-121 | Pro residues | ||||
Sequence: PAAPVPTPICPTTTPPPPPPPSPEA |
Keywords
- Coding sequence diversity
- Technical term