P03129 · VE7_HPV16

Function

function

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).

Miscellaneous

HPV16, in comparison to HPV types 6 and 11, is more often associated with malignant genital cancers in humans.
Part of the antigens expressed and presented within HPV-positive head and neck tumors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular Functioncadmium ion binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor binding
Molecular Functionprotein domain specific binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processpositive regulation of actin filament polymerization
Biological Processsymbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
Biological Processsymbiont-mediated perturbation of host transcription
Biological Processsymbiont-mediated suppression of host apoptosis
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral process
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein E7

Gene names

    • Name
      E7

Organism names

  • Taxonomic identifier
  • Strains
    • Isolate African 1
    • Isolate European German 131
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 9

Accessions

  • Primary accession
    P03129

Proteomes

Subcellular Location

Host cytoplasm
Host nucleus
Note: Predominantly found in the host nucleus.

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis67Complete loss of interaction with HDAC1 and transformation ability.
Mutagenesis82-83Complete loss of interaction with HDAC1 and transformation ability.
Mutagenesis91Complete loss of interaction with HDAC1 and transformation ability.

Keywords

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001334141-98Protein E7

Post-translational modification

Highly phosphorylated.

PTM databases

Expression

Keywords

Interaction

Subunit

Homodimer (PubMed:11123931).
Homooligomer (PubMed:15035602).
Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity (PubMed:1316611).
Interacts with host EP300; this interaction represses EP300 transcriptional activity (PubMed:12970734).
Forms a complex with CHD4 and HDAC1, thereby altering the action of host histone deacetylation. A similar complex involving E7, CHD4 and HDAC2 may also form (PubMed:10228159).
Interacts with protein E2; this interaction inhibits E7 oncogenic activity (PubMed:16439535).

Binary interactions

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, motif, zinc finger.

TypeIDPosition(s)Description
Region1-40E7 terminal domain
Motif22-26LXCXE motif; interaction with host RB1 and TMEM173/STING
Zinc finger58-94
Motif76-84Nuclear export signal

Domain

The E7 terminal domain is an intrinsically disordered domain, whose flexibility and conformational transitions confer target adaptability to the oncoprotein. It allows adaptation to a variety of protein targets and exposes the PEST degradation sequence that regulates its turnover in the cell.

Sequence similarities

Belongs to the papillomaviridae E7 protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    98
  • Mass (Da)
    11,022
  • Last updated
    1986-07-21 v1
  • Checksum
    9BD612534CD2C9EB
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
K02718
EMBL· GenBank· DDBJ
AAA46940.1
EMBL· GenBank· DDBJ
Genomic DNA
D00735
EMBL· GenBank· DDBJ
BAA00633.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003020
EMBL· GenBank· DDBJ
AAB70737.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003023
EMBL· GenBank· DDBJ
AAB70740.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003024
EMBL· GenBank· DDBJ
AAB70741.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003025
EMBL· GenBank· DDBJ
AAB70742.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003026
EMBL· GenBank· DDBJ
AAB70743.1
EMBL· GenBank· DDBJ
Genomic DNA
U76411
EMBL· GenBank· DDBJ
AAB18962.1
EMBL· GenBank· DDBJ
Genomic DNA
U76412
EMBL· GenBank· DDBJ
AAB18963.1
EMBL· GenBank· DDBJ
Genomic DNA
U76413
EMBL· GenBank· DDBJ
AAB18964.1
EMBL· GenBank· DDBJ
Genomic DNA
AF536179
EMBL· GenBank· DDBJ
AAQ10713.1
EMBL· GenBank· DDBJ
Genomic DNA
AF536180
EMBL· GenBank· DDBJ
AAQ10721.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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