P03093 · VP2_SV40
- ProteinMinor capsid protein VP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids352 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform VP2
Isoform VP3
Isoform VP4
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell | |
Cellular Component | host cell endoplasmic reticulum membrane | |
Cellular Component | host cell nucleus | |
Cellular Component | membrane | |
Cellular Component | viral capsid | |
Molecular Function | channel activity | |
Molecular Function | DNA binding | |
Molecular Function | structural molecule activity | |
Biological Process | monoatomic ion transmembrane transport | |
Biological Process | symbiont entry into host cell via permeabilization of host membrane | |
Biological Process | viral penetration into host nucleus | |
Biological Process | virion attachment to host cell |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMinor capsid protein VP2
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Sepolyvirales > Polyomaviridae > Betapolyomavirus
- Virus hosts
Accessions
- Primary accessionP03093
Proteomes
Subcellular Location
Isoform VP2
Isoform VP3
Isoform VP4
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 290-310 | Helical | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 63 | in strain: 776 | |||
Mutagenesis | 276-277 | Complete loss of interaction with VP1. | |||
Mutagenesis | 283-285 | Complete loss of interaction with VP1. | |||
Mutagenesis | 296 | Partial loss of interaction with VP1. | |||
Mutagenesis | 300 | Partial loss of interaction with VP1. | |||
Mutagenesis | 344 | Partial loss of DNA-binding activity. | |||
Mutagenesis | 348 | Partial loss of DNA-binding activity. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed; by host | |||
Lipidation | 2 | N-myristoyl glycine; by host | |||
Chain | PRO_0000039223 | 2-352 | Minor capsid protein VP2 | ||
Keywords
- PTM
PTM databases
Expression
Keywords
- Developmental stage
Interaction
Subunit
Isoform VP2
Isoform VP3
Interacts (via C-terminus) with host SP1, this is probably also the case for VP2; this interaction represses SP1 activation of the SV40 early promoter and participates in virion assembly (PubMed:9466902).
Interacts (via nuclear localization signal) with host importin alpha2-beta heterodimer (PubMed:12186919).
Isoform VP4
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P03093 | P03087 | 3 | EBI-1555798, EBI-1555770 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, motif, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 273-308 | D1 | |||
Region | 313-352 | Disordered | |||
Region | 313-352 | DNA-binding | |||
Motif | 316-324 | Nuclear localization signal | |||
Compositional bias | 337-352 | Basic residues | |||
Domain
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing & Alternative initiation.
P03093-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameVP2
- SynonymsMinor capsid protein VP2
- NoteProduced by alternative splicing of the late mRNA (19s mRNA).
- Length352
- Mass (Da)38,539
- Last updated2007-01-23 v3
- Checksum79A1C73604646923
P03093-2
- NameVP3
- SynonymsMinor capsid protein VP3
- NoteProduced by alternative initiation at Met-119 of isoform VP2.
- Differences from canonical
- 1-118: Missing
P03093-3
- NameVP4
- SynonymsViroporin VP4
- NoteProduced by alternative initiation at Met-228 of isoform VP2.
- Differences from canonical
- 1-227: Missing
P03087-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameVP1
- SynonymsMajor capsid protein VP1
P03084-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameAgno
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_018925 | 1-118 | in isoform VP3 | ||
Alternative sequence | VSP_035892 | 1-227 | in isoform VP4 | ||
Compositional bias | 337-352 | Basic residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J02400 EMBL· GenBank· DDBJ | AAB59921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
J02400 EMBL· GenBank· DDBJ | AAB59922.1 EMBL· GenBank· DDBJ | Genomic DNA |