P03086 · AGNO_POVJC
- ProteinAgnoprotein
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell nuclear membrane | |
Cellular Component | host cell plasma membrane | |
Cellular Component | host cell rough endoplasmic reticulum membrane | |
Cellular Component | membrane | |
Molecular Function | channel activity | |
Molecular Function | DNA binding | |
Biological Process | monoatomic ion transmembrane transport |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAgnoprotein
- Alternative names
Organism names
- Organism
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Sepolyvirales > Polyomaviridae > Betapolyomavirus > Betapolyomavirus secuhominis
- Virus hosts
Accessions
- Primary accessionP03086
Proteomes
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-27 | Cytoplasmic | ||||
Sequence: MVLRQLSRKASVKVSKTWSGTKKRAQR | ||||||
Transmembrane | 28-44 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: ILIFLLEFLLDFCTGED | ||||||
Topological domain | 45-71 | Extracellular | ||||
Sequence: SVDGKKRQRHSGLTEQTYSALPEPKAT |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 7 | Partial loss of phosphorylation, defective in encapsidation of viral DNA; when associated with A-8 and T-21. | ||||
Sequence: S → A | ||||||
Mutagenesis | 8-9 | Impaired viral propagation. | ||||
Sequence: RK → AA | ||||||
Mutagenesis | 11 | Partial loss of phosphorylation, defective in encapsidation of viral DNA; when associated with A-7 and T-21. | ||||
Sequence: S → A | ||||||
Mutagenesis | 21 | Partial loss of phosphorylation, defective in encapsidation of viral DNA; when associated with A-7 and A-8. | ||||
Sequence: T → A |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000115033 | 1-71 | Agnoprotein | |||
Sequence: MVLRQLSRKASVKVSKTWSGTKKRAQRILIFLLEFLLDFCTGEDSVDGKKRQRHSGLTEQTYSALPEPKAT | ||||||
Modified residue | 7 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 11 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 21 | Phosphothreonine; by host | ||||
Sequence: T |
Post-translational modification
Keywords
- PTM
PTM databases
Interaction
Subunit
Interacts with large T antigen; this interaction may impact upon the activity of T-antigen on the control of viral gene transcription and replication. Interacts with small t antigen. Interacts with host PP2A subunits for dephosphorylation. Interacts (via N-terminus) with host YBX1; this interaction modulates transcriptional activity genomic promoters. Interacts (via N-terminus) with host TP53. Interacts with host FEZ1; this interaction disrupts the association between FEZ1 and microtubules. Interacts with host CBX5; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 45-71 | Disordered | ||||
Sequence: SVDGKKRQRHSGLTEQTYSALPEPKAT |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing & Alternative initiation.
P03086-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameAgno
- NoteProduced by alternative initiation of the late mRNA.
- Length71
- Mass (Da)8,081
- Last updated1986-07-21 v1
- Checksum3E459BFCC541E53B
P03089-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameVP1
- SynonymsMajor capsid protein VP1
P03095-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameVP2
- SynonymsMinor capsid protein VP2
P03095-2
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameVP3
- SynonymsMinor capsid protein VP3
P03095-3
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameVP4
- SynonymsViroporin VP4
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J02226 EMBL· GenBank· DDBJ | AAA82098.1 EMBL· GenBank· DDBJ | Genomic DNA |