P03086 · AGNO_POVJC

Function

function

Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nuclear membrane
Cellular Componenthost cell plasma membrane
Cellular Componenthost cell rough endoplasmic reticulum membrane
Cellular Componentmembrane
Molecular Functionchannel activity
Molecular FunctionDNA binding
Biological Processmonoatomic ion transmembrane transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Agnoprotein
  • Alternative names
    • Agno

Organism names

Accessions

  • Primary accession
    P03086

Proteomes

Subcellular Location

Host nucleus membrane
; Single-pass type II membrane protein
Host rough endoplasmic reticulum membrane
; Single-pass type II membrane protein
Host cell membrane
; Single-pass type II membrane protein
Note: Mostly perinuclear.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-27Cytoplasmic
Transmembrane28-44Helical; Signal-anchor for type II membrane protein
Topological domain45-71Extracellular

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis7Partial loss of phosphorylation, defective in encapsidation of viral DNA; when associated with A-8 and T-21.
Mutagenesis8-9Impaired viral propagation.
Mutagenesis11Partial loss of phosphorylation, defective in encapsidation of viral DNA; when associated with A-7 and T-21.
Mutagenesis21Partial loss of phosphorylation, defective in encapsidation of viral DNA; when associated with A-7 and A-8.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001150331-71Agnoprotein
Modified residue7Phosphoserine; by host
Modified residue11Phosphoserine; by host
Modified residue21Phosphothreonine; by host

Post-translational modification

Phosphorylated by host PKC. Phosphorylation alters the stability and may also have an impact on the subcellular location (By similarity).

Keywords

PTM databases

Interaction

Subunit

Homooligomer. Interacts with VP1 (By similarity).
Interacts with large T antigen; this interaction may impact upon the activity of T-antigen on the control of viral gene transcription and replication. Interacts with small t antigen. Interacts with host PP2A subunits for dephosphorylation. Interacts (via N-terminus) with host YBX1; this interaction modulates transcriptional activity genomic promoters. Interacts (via N-terminus) with host TP53. Interacts with host FEZ1; this interaction disrupts the association between FEZ1 and microtubules. Interacts with host CBX5; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region45-71Disordered

Sequence similarities

Belongs to the polyomavirus agnoprotein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing & Alternative initiation.

P03086-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Agno
  • Note
    Produced by alternative initiation of the late mRNA.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    71
  • Mass (Da)
    8,081
  • Last updated
    1986-07-21 v1
  • Checksum
    3E459BFCC541E53B
MVLRQLSRKASVKVSKTWSGTKKRAQRILIFLLEFLLDFCTGEDSVDGKKRQRHSGLTEQTYSALPEPKAT

P03089-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform
  • Name
    VP1
  • Synonyms
    Major capsid protein VP1
  • See also
    sequence in UniParc or sequence clusters in UniRef

P03095-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform
  • Name
    VP2
  • Synonyms
    Minor capsid protein VP2
  • See also
    sequence in UniParc or sequence clusters in UniRef

P03095-2

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform
  • Name
    VP3
  • Synonyms
    Minor capsid protein VP3
  • See also
    sequence in UniParc or sequence clusters in UniRef

P03095-3

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform
  • Name
    VP4
  • Synonyms
    Viroporin VP4
  • See also
    sequence in UniParc or sequence clusters in UniRef

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J02226
EMBL· GenBank· DDBJ
AAA82098.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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