The interaction between beta2GPI and TLR4 is confirmed by the reduction of anti-beta2GPI antibody binding and by the up-regulation of E-selectin or ICAM-1 by TLR4 silencing in HUVEC.
results demonstrate that Ro 60 functions as a novel receptor for beta(2)GPI on the surface of apoptotic cells. The formation of Ro 60-beta(2)GPI complexes may protect against anti-Ro 60 autoantibody-mediated tissue injury.
platelets adhere to dimeric beta2GPI under both arterial and venous shear stresses. Platelets adhere via two receptors: GPIbalpha and apoER2'. These receptors are present in a complex on the platelet surface
During Glu-Plasminogen activation we found increase in plasmin generation both at fibrin & cellular surface level as a function of concentration of beta2GPI added suggesting important role as cofactor in trimolecular complex beta2GPI-Plasminogen-tPA.
The study provides first demonstration of the occurrence of anti-phospholipid and anti-beta2-GPI activities separately on heavy and light chains of an autoantibody.
omega-carboxyl variants of 7-ketocholesteryl esters can mediate anti-beta(2)-GPI Ab-dependent uptake of oxLDL by macrophages and autoimmune atherogenesis linked to beta(2)-GPI interaction with oxLDL
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