P02742 · CRP_RABIT

Function

function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).

Miscellaneous

Asp-61, Arg-76, Arg-77, and Glu-81 may be involved in the calcium-dependent binding of phosphorylcholine, a property that may be important for the biological function of this protein.

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 2 calcium ions per subunit.

Features

Showing features for binding site.

122520406080100120140160180200220
TypeIDPosition(s)Description
Binding site80Ca2+ 1 (UniProtKB | ChEBI)
Binding site158Ca2+ 1 (UniProtKB | ChEBI)
Binding site159Ca2+ 1 (UniProtKB | ChEBI)
Binding site159Ca2+ 2 (UniProtKB | ChEBI)
Binding site169Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular Functioncomplement component C1q complex binding
Molecular Functionlow-density lipoprotein particle binding
Molecular Functionmetal ion binding
Biological Processacute-phase response
Biological Processinnate immune response
Biological Processregulation of interleukin-8 production

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C-reactive protein

Gene names

    • Name
      CRP
    • Synonyms
      PTX1

Organism names

  • Taxonomic identifier
  • Strain
    • New Zealand white
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    P02742

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant62
Natural variant89

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000002353121-225C-reactive protein
Disulfide bond55↔116

Keywords

Proteomic databases

Expression

Tissue specificity

Found in plasma.

Induction

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Interaction

Subunit

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-225Pentraxin (PTX)

Sequence similarities

Belongs to the pentraxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    225
  • Mass (Da)
    25,493
  • Last updated
    1988-01-01 v1
  • Checksum
    C6D634FDE844438F
MEKLLWCFLTLVSFSNMSDQAGMHKKAFVFPKESDNSYVSLNAQLKKPLKAFTVCLYFYTDLSMTRGYSIFSYATRRQFNEILLFWSKDIGYSFSVGGDEIIFKVSDIPVDPTHLCASWESSTGIAELWVDGKPMVRKSLKKGYILGPEASIILGQDQDSFGGSFEKQQSLVGDIGNVNMWDYALSPEEINTIYAGGTFSPNVLDWRELTYQVRGEVHVKPQLWP

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict10in Ref. 2; AAA31206
Sequence conflict46in Ref. 3; AA sequence
Sequence conflict50in Ref. 3; AA sequence
Sequence conflict76in Ref. 1; AAA75404
Sequence conflict84-88in Ref. 3; AA sequence
Sequence conflict91in Ref. 3; AA sequence
Sequence conflict93-101in Ref. 3; AA sequence
Sequence conflict108in Ref. 2; AAA31206
Sequence conflict167in Ref. 3; AA sequence
Sequence conflict177in Ref. 3; AA sequence
Sequence conflict193in Ref. 2; AAA31206

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M14538
EMBL· GenBank· DDBJ
AAA75403.1
EMBL· GenBank· DDBJ
Genomic DNA
L47237
EMBL· GenBank· DDBJ
AAA75404.1
EMBL· GenBank· DDBJ
mRNA
M13497
EMBL· GenBank· DDBJ
AAA31206.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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