P02670 · CASK_CAPHI

  • Protein
    Kappa-casein
  • Gene
    CSN3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

Features

Showing features for site.

119220406080100120140160180
TypeIDPosition(s)Description
Site126-127Cleavage; by chymosin/rennin

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Biological Processlactation
Biological Processprotein stabilization

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Kappa-casein
  • Short names
    Kappa-CN

Gene names

    • Name
      CSN3
    • Synonyms
      CSN10, CSNK

Organism names

  • Taxonomic identifier
  • Strain
    • Ssp. aegagrus
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    P02670
  • Secondary accessions
    • Q8SPM9
    • Q8SPN0
    • Q8SPV1
    • Q8SPW6
    • Q8SPW7

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant65in allele CSN3-B
Natural variant86in allele CSN3-B, allele C and allele G
Natural variant111in allele E
Natural variant140in allele CSN3-B, allele B, allele C, allele E, allele F and allele G
Natural variant177in allele C
Natural variant180in allele CSN3-B, allele C, allele F and allele G

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Protein family/group databases

PTM/Processing

Features

Showing features for signal, modified residue, chain, glycosylation.

Type
IDPosition(s)Description
Signal1-21
Modified residue22Pyrrolidone carboxylic acid
ChainPRO_000000449222-192Kappa-casein
Modified residue148Phosphoserine
Glycosylation152O-linked (GalNAc...) threonine
Glycosylation155O-linked (GalNAc...) serine
Glycosylation156O-linked (GalNAc...) threonine
Glycosylation159O-linked (GalNAc...) threonine
Glycosylation165O-linked (GalNAc...) threonine
Modified residue172Phosphoserine; alternate
Glycosylation172O-linked (GalNAc...) serine; alternate
Glycosylation188O-linked (GalNAc...) threonine
Modified residue189Phosphoserine

Keywords

PTM databases

Expression

Tissue specificity

Mammary gland specific. Secreted in milk.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region167-192Disordered

Sequence similarities

Belongs to the kappa-casein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    192
  • Mass (Da)
    21,441
  • Last updated
    1992-08-01 v2
  • Checksum
    009F5858F4BFB178
MMKSFFLVVTILALTLPFLGAQEQNQEQPICCEKDERFFDDKIAKYIPIQYVLSRYPSYGLNYYQQRPVALINNQFLPYPYYAKPVAVRSPAQTLQWQVLPNTVPAKSCQDQPTTLARHPHPHLSFMAIPPKKDQDKTEVPAINTIASAEPTVHSTPTTEAIVNTVDNPEASSESIASASETNTAQVTSTEV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict134in Ref. 3; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D14373
EMBL· GenBank· DDBJ
BAA03286.1
EMBL· GenBank· DDBJ
Genomic DNA
X60763
EMBL· GenBank· DDBJ
CAA43174.1
EMBL· GenBank· DDBJ
mRNA
AY027868
EMBL· GenBank· DDBJ
AAK17010.1
EMBL· GenBank· DDBJ
Genomic DNA
AF485339
EMBL· GenBank· DDBJ
AAL90871.1
EMBL· GenBank· DDBJ
Genomic DNA
AF485340
EMBL· GenBank· DDBJ
AAL90872.1
EMBL· GenBank· DDBJ
Genomic DNA
AF485341
EMBL· GenBank· DDBJ
AAL90873.1
EMBL· GenBank· DDBJ
Genomic DNA
AF486523
EMBL· GenBank· DDBJ
AAL93193.1
EMBL· GenBank· DDBJ
Genomic DNA
AY090465
EMBL· GenBank· DDBJ
AAM12025.1
EMBL· GenBank· DDBJ
Genomic DNA
AY090466
EMBL· GenBank· DDBJ
AAM12026.1
EMBL· GenBank· DDBJ
Genomic DNA
AY090467
EMBL· GenBank· DDBJ
AAM12027.1
EMBL· GenBank· DDBJ
Genomic DNA
AF434988
EMBL· GenBank· DDBJ
AAL31535.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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