P02670 · CASK_CAPHI
- ProteinKappa-casein
- GeneCSN3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids192 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 126-127 | Cleavage; by chymosin/rennin | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Biological Process | lactation | |
Biological Process | protein stabilization |
Keywords
- Molecular function
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameKappa-casein
- Short namesKappa-CN
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra
Accessions
- Primary accessionP02670
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 65 | in allele CSN3-B | |||
Natural variant | 86 | in allele CSN3-B, allele C and allele G | |||
Natural variant | 111 | in allele E | |||
Natural variant | 140 | in allele CSN3-B, allele B, allele C, allele E, allele F and allele G | |||
Natural variant | 177 | in allele C | |||
Natural variant | 180 | in allele CSN3-B, allele C, allele F and allele G | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
Protein family/group databases
PTM/Processing
Features
Showing features for signal, modified residue, chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Modified residue | 22 | Pyrrolidone carboxylic acid | |||
Chain | PRO_0000004492 | 22-192 | Kappa-casein | ||
Modified residue | 148 | Phosphoserine | |||
Glycosylation | 152 | O-linked (GalNAc...) threonine | |||
Glycosylation | 155 | O-linked (GalNAc...) serine | |||
Glycosylation | 156 | O-linked (GalNAc...) threonine | |||
Glycosylation | 159 | O-linked (GalNAc...) threonine | |||
Glycosylation | 165 | O-linked (GalNAc...) threonine | |||
Modified residue | 172 | Phosphoserine; alternate | |||
Glycosylation | 172 | O-linked (GalNAc...) serine; alternate | |||
Glycosylation | 188 | O-linked (GalNAc...) threonine | |||
Modified residue | 189 | Phosphoserine | |||
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Mammary gland specific. Secreted in milk.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length192
- Mass (Da)21,441
- Last updated1992-08-01 v2
- Checksum009F5858F4BFB178
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 134 | in Ref. 3; AA sequence | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D14373 EMBL· GenBank· DDBJ | BAA03286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X60763 EMBL· GenBank· DDBJ | CAA43174.1 EMBL· GenBank· DDBJ | mRNA | ||
AY027868 EMBL· GenBank· DDBJ | AAK17010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF485339 EMBL· GenBank· DDBJ | AAL90871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF485340 EMBL· GenBank· DDBJ | AAL90872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF485341 EMBL· GenBank· DDBJ | AAL90873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF486523 EMBL· GenBank· DDBJ | AAL93193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY090465 EMBL· GenBank· DDBJ | AAM12025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY090466 EMBL· GenBank· DDBJ | AAM12026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY090467 EMBL· GenBank· DDBJ | AAM12027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF434988 EMBL· GenBank· DDBJ | AAL31535.1 EMBL· GenBank· DDBJ | Genomic DNA |