P02585 · TNNC2_HUMAN

  • Protein
    Troponin C, skeletal muscle
  • Gene
    TNNC2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Features

Showing features for binding site.

116020406080100120140160
TypeIDPosition(s)Description
Binding site28Ca2+ 1 (UniProtKB | ChEBI)
Binding site30Ca2+ 1 (UniProtKB | ChEBI)
Binding site34Ca2+ 1 (UniProtKB | ChEBI)
Binding site39Ca2+ 1 (UniProtKB | ChEBI)
Binding site64Ca2+ 2 (UniProtKB | ChEBI)
Binding site66Ca2+ 2 (UniProtKB | ChEBI)
Binding site68Ca2+ 2 (UniProtKB | ChEBI)
Binding site70Ca2+ 2 (UniProtKB | ChEBI)
Binding site75Ca2+ 2 (UniProtKB | ChEBI)
Binding site104Ca2+ 3 (UniProtKB | ChEBI)
Binding site106Ca2+ 3 (UniProtKB | ChEBI)
Binding site108Ca2+ 3 (UniProtKB | ChEBI)
Binding site110Ca2+ 3 (UniProtKB | ChEBI)
Binding site115Ca2+ 3 (UniProtKB | ChEBI)
Binding site140Ca2+ 4 (UniProtKB | ChEBI)
Binding site142Ca2+ 4 (UniProtKB | ChEBI)
Binding site144Ca2+ 4 (UniProtKB | ChEBI)
Binding site146Ca2+ 4 (UniProtKB | ChEBI)
Binding site151Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componenttroponin complex
Molecular Functioncalcium ion binding
Biological Processregulation of muscle contraction
Biological Processskeletal muscle contraction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Troponin C, skeletal muscle

Gene names

    • Name
      TNNC2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P02585
  • Secondary accessions
    • Q6FH92

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Involvement in disease

Congenital myopathy 15 (CMYP15)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    An autosomal dominant myopathy characterized by neonatal onset of hypotonia, muscle weakness, and respiratory muscle involvement resulting in severe respiratory insufficiency. The disorder improves over time, although forced vital capacity remains decreased. Other features include facial weakness, often with ptosis or external ophthalmoplegia, jaw or distal joint contractures, scoliosis, and osteopenia.
  • See also
    MIM:620161
Natural variants in CMYP15
Variant IDPosition(s)ChangeDescription
VAR_08797834D>Yin CMYP15; affects regulation of muscle contraction
VAR_08797979M>Iin CMYP15; affects regulation of muscle contraction; dbSNP:rs1804548

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_08797834in CMYP15; affects regulation of muscle contraction
Natural variantVAR_08797979in CMYP15; affects regulation of muscle contraction; dbSNP:rs1804548

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 173 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylthreonine
ChainPRO_00000737032-160UniProtTroponin C, skeletal muscle
Modified residue (large scale data)92PRIDEPhosphoserine
Modified residue (large scale data)134PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P02585TBC1D1 Q86TI03EBI-10249681, EBI-1644036
BINARY P02585TNNI3 P194293EBI-10249681, EBI-704146
BINARY P02585TNNI3 Q6FGX23EBI-10249681, EBI-10249686

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-50EF-hand 1
Domain51-86EF-hand 2
Domain91-126EF-hand 3
Domain127-160EF-hand 4

Sequence similarities

Belongs to the troponin C family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    160
  • Mass (Da)
    18,122
  • Last updated
    2007-01-23 v2
  • Checksum
    EA93729732A0F916
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
C9J7T9C9J7T9_HUMANTNNC2145

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict2-3in Ref. 9; AA sequence
Sequence conflict114in Ref. 3; AAA91854

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X07898
EMBL· GenBank· DDBJ
CAA30737.1
EMBL· GenBank· DDBJ
mRNA
M33772
EMBL· GenBank· DDBJ
AAA61197.1
EMBL· GenBank· DDBJ
Genomic DNA
M33771
EMBL· GenBank· DDBJ
AAA61197.1
EMBL· GenBank· DDBJ
Genomic DNA
M22307
EMBL· GenBank· DDBJ
AAA91854.1
EMBL· GenBank· DDBJ
mRNA
AK291323
EMBL· GenBank· DDBJ
BAF84012.1
EMBL· GenBank· DDBJ
mRNA
CR541864
EMBL· GenBank· DDBJ
CAG46662.1
EMBL· GenBank· DDBJ
mRNA
CR541884
EMBL· GenBank· DDBJ
CAG46682.1
EMBL· GenBank· DDBJ
mRNA
CH471077
EMBL· GenBank· DDBJ
EAW75803.1
EMBL· GenBank· DDBJ
Genomic DNA
AL050348
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC005323
EMBL· GenBank· DDBJ
AAH05323.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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