P02585 · TNNC2_HUMAN
- ProteinTroponin C, skeletal muscle
- GeneTNNC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids160 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Miscellaneous
Skeletal muscle troponin C binds four calcium ions.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 28 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 30 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 34 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 39 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 64 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 66 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 68 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 70 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 75 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 104 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 106 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 108 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 110 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 115 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 140 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 142 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 144 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 146 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 151 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | troponin complex | |
Molecular Function | calcium ion binding | |
Biological Process | regulation of muscle contraction | |
Biological Process | skeletal muscle contraction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTroponin C, skeletal muscle
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP02585
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Involvement in disease
Congenital myopathy 15 (CMYP15)
- Note
- DescriptionAn autosomal dominant myopathy characterized by neonatal onset of hypotonia, muscle weakness, and respiratory muscle involvement resulting in severe respiratory insufficiency. The disorder improves over time, although forced vital capacity remains decreased. Other features include facial weakness, often with ptosis or external ophthalmoplegia, jaw or distal joint contractures, scoliosis, and osteopenia.
- See alsoMIM:620161
Natural variants in CMYP15
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_087978 | 34 | D>Y | in CMYP15; affects regulation of muscle contraction | |
VAR_087979 | 79 | M>I | in CMYP15; affects regulation of muscle contraction; dbSNP:rs1804548 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_087978 | 34 | in CMYP15; affects regulation of muscle contraction | |||
Sequence: D → Y | ||||||
Natural variant | VAR_087979 | 79 | in CMYP15; affects regulation of muscle contraction; dbSNP:rs1804548 | |||
Sequence: M → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 173 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylthreonine | ||||
Sequence: T | |||||||
Chain | PRO_0000073703 | 2-160 | UniProt | Troponin C, skeletal muscle | |||
Sequence: TDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ | |||||||
Modified residue (large scale data) | 92 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 134 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P02585 | TBC1D1 Q86TI0 | 3 | EBI-10249681, EBI-1644036 | |
BINARY | P02585 | TNNI3 P19429 | 3 | EBI-10249681, EBI-704146 | |
BINARY | P02585 | TNNI3 Q6FGX2 | 3 | EBI-10249681, EBI-10249686 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-50 | EF-hand 1 | ||||
Sequence: EMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQT | ||||||
Domain | 51-86 | EF-hand 2 | ||||
Sequence: PTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKE | ||||||
Domain | 91-126 | EF-hand 3 | ||||
Sequence: KSEEELAECFRIFDRNADGYIDPEELAEIFRASGEH | ||||||
Domain | 127-160 | EF-hand 4 | ||||
Sequence: VTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ |
Sequence similarities
Belongs to the troponin C family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length160
- Mass (Da)18,122
- Last updated2007-01-23 v2
- ChecksumEA93729732A0F916
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
C9J7T9 | C9J7T9_HUMAN | TNNC2 | 145 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 2-3 | in Ref. 9; AA sequence | ||||
Sequence: TD → DT | ||||||
Sequence conflict | 114 | in Ref. 3; AAA91854 | ||||
Sequence: E → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X07898 EMBL· GenBank· DDBJ | CAA30737.1 EMBL· GenBank· DDBJ | mRNA | ||
M33772 EMBL· GenBank· DDBJ | AAA61197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M33771 EMBL· GenBank· DDBJ | AAA61197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22307 EMBL· GenBank· DDBJ | AAA91854.1 EMBL· GenBank· DDBJ | mRNA | ||
AK291323 EMBL· GenBank· DDBJ | BAF84012.1 EMBL· GenBank· DDBJ | mRNA | ||
CR541864 EMBL· GenBank· DDBJ | CAG46662.1 EMBL· GenBank· DDBJ | mRNA | ||
CR541884 EMBL· GenBank· DDBJ | CAG46682.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471077 EMBL· GenBank· DDBJ | EAW75803.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL050348 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC005323 EMBL· GenBank· DDBJ | AAH05323.1 EMBL· GenBank· DDBJ | mRNA |