P02319 · HSP1_MOUSE
- ProteinSperm protamine P1
- GenePrm1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | male germ cell nucleus | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleosome | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Biological Process | chromosome condensation | |
Biological Process | nucleus organization | |
Biological Process | sperm DNA condensation | |
Biological Process | spermatid development |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSperm protamine P1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP02319
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000191498 | 1-51 | Sperm protamine P1 | |||
Sequence: MARYRCCRSKSRSRCRRRRRRCRRRRRRCCRRRRRRCCRRRRSYTIRCKKY | ||||||
Disulfide bond | 6 | Interchain (with C-22) | ||||
Sequence: C | ||||||
Disulfide bond | 7↔15 | |||||
Sequence: CRSKSRSRC | ||||||
Disulfide bond | 22 | Interchain (with C-6) | ||||
Sequence: C | ||||||
Disulfide bond | 37 | Interchain (with C-37) | ||||
Sequence: C | ||||||
Disulfide bond | 38↔48 | |||||
Sequence: CRRRRSYTIRC |
Post-translational modification
Phosphorylated by SRPK1.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Sequence similarities
Belongs to the protamine P1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length51
- Mass (Da)6,958
- Last updated2007-01-23 v2
- ChecksumB61CD660AD1D7978
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
K02926 EMBL· GenBank· DDBJ | AAA39980.1 EMBL· GenBank· DDBJ | mRNA | ||
X07625 EMBL· GenBank· DDBJ | CAA30472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X14003 EMBL· GenBank· DDBJ | CAA32169.1 EMBL· GenBank· DDBJ | mRNA | ||
M27500 EMBL· GenBank· DDBJ | AAA39985.1 EMBL· GenBank· DDBJ | mRNA | ||
Z47352 EMBL· GenBank· DDBJ | CAA87410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK007068 EMBL· GenBank· DDBJ | BAC25162.1 EMBL· GenBank· DDBJ | mRNA | ||
BC059733 EMBL· GenBank· DDBJ | AAH59733.1 EMBL· GenBank· DDBJ | mRNA |