P02319 · HSP1_MOUSE

  • Protein
    Sperm protamine P1
  • Gene
    Prm1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmale germ cell nucleus
Cellular Componentnucleoplasm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Biological Processchromosome condensation
Biological Processnucleus organization
Biological Processsperm DNA condensation
Biological Processspermatid development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sperm protamine P1
  • Alternative names
    • Cysteine-rich protamine

Gene names

    • Name
      Prm1
    • Synonyms
      Prm-1

Organism names

  • Taxonomic identifier
  • Strains
    • C129
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P02319

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001914981-51Sperm protamine P1
Disulfide bond6Interchain (with C-22)
Disulfide bond7↔15
Disulfide bond22Interchain (with C-6)
Disulfide bond37Interchain (with C-37)
Disulfide bond38↔48

Post-translational modification

Phosphorylated by SRPK1.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Testis.

Gene expression databases

Interaction

Subunit

Cross-linked by interchain disulfide bonds around the DNA-helix.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    51
  • Mass (Da)
    6,958
  • Last updated
    2007-01-23 v2
  • Checksum
    B61CD660AD1D7978
MARYRCCRSKSRSRCRRRRRRCRRRRRRCCRRRRRRCCRRRRSYTIRCKKY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
K02926
EMBL· GenBank· DDBJ
AAA39980.1
EMBL· GenBank· DDBJ
mRNA
X07625
EMBL· GenBank· DDBJ
CAA30472.1
EMBL· GenBank· DDBJ
Genomic DNA
X14003
EMBL· GenBank· DDBJ
CAA32169.1
EMBL· GenBank· DDBJ
mRNA
M27500
EMBL· GenBank· DDBJ
AAA39985.1
EMBL· GenBank· DDBJ
mRNA
Z47352
EMBL· GenBank· DDBJ
CAA87410.1
EMBL· GenBank· DDBJ
Genomic DNA
AK007068
EMBL· GenBank· DDBJ
BAC25162.1
EMBL· GenBank· DDBJ
mRNA
BC059733
EMBL· GenBank· DDBJ
AAH59733.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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