P02088 · HBB1_MOUSE
- ProteinHemoglobin subunit beta-1
- GeneHbb-b1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids147 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in oxygen transport from the lung to the various peripheral tissues.
Miscellaneous
The D-major sequence is shown. See also the entry for the beta D and P-minor chain.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | haptoglobin-hemoglobin complex | |
Cellular Component | hemoglobin complex | |
Cellular Component | myelin sheath | |
Molecular Function | heme binding | |
Molecular Function | hemoglobin alpha binding | |
Molecular Function | hemoglobin beta binding | |
Molecular Function | metal ion binding | |
Molecular Function | organic acid binding | |
Molecular Function | oxygen binding | |
Molecular Function | oxygen carrier activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | carbon dioxide transport | |
Biological Process | cellular oxidant detoxification | |
Biological Process | erythrocyte development | |
Biological Process | hemopoiesis | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | nitric oxide transport | |
Biological Process | oxygen transport | |
Biological Process | regulation of eIF2 alpha phosphorylation by heme |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHemoglobin subunit beta-1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP02088
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 14 | in allele S and allele W1 | ||||
Sequence: C → G | ||||||
Natural variant | 21 | in allele S | ||||
Sequence: S → A | ||||||
Natural variant | 74 | in allele W1 | ||||
Sequence: D → E | ||||||
Natural variant | 135 | in allele W1 | ||||
Sequence: V → M | ||||||
Natural variant | 140 | in allele S | ||||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 5 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylvaline | ||||
Sequence: V | ||||||
Chain | PRO_0000053024 | 2-147 | Hemoglobin subunit beta-1 | |||
Sequence: VHLTDAEKAAVSCLWGKVNSDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH | ||||||
Modified residue | 18 | N6-succinyllysine | ||||
Sequence: K | ||||||
Modified residue | 21 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 45 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 51 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 60 | N6-succinyllysine | ||||
Sequence: K | ||||||
Modified residue | 105 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 124 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
2D gel databases
PTM databases
Expression
Tissue specificity
Red blood cells.
Interaction
Subunit
Heterotetramer of two alpha chains and two beta chains.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-147 | Globin | ||||
Sequence: HLTDAEKAAVSCLWGKVNSDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH |
Sequence similarities
Belongs to the globin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length147
- Mass (Da)15,840
- Last updated2007-01-23 v2
- Checksum8190EAEEFD9036A3
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 15 | in Ref. 6; BAB27362 | ||||
Sequence: L → Q | ||||||
Sequence conflict | 39 | in Ref. 6; BAB29299 | ||||
Sequence: T → A | ||||||
Sequence conflict | 63 | in Ref. 6; BAB27237 | ||||
Sequence: A → T | ||||||
Sequence conflict | 91 | in Ref. 3 | ||||
Sequence: E → Q | ||||||
Sequence conflict | 109 | in Ref. 6; BAB29299 | ||||
Sequence: N → S |
Polymorphism
Inbred mouse strains possess 1 of 4 alleles at the HBB locus: D (diffuse), S (single), P and W1. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice. The W1 allele is observed mainly in Northwestern China.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X14061 EMBL· GenBank· DDBJ | CAA32224.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
J00413 EMBL· GenBank· DDBJ | AAA37791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB020013 EMBL· GenBank· DDBJ | BAA77353.1 EMBL· GenBank· DDBJ | mRNA | ||
AB020015 EMBL· GenBank· DDBJ | BAA77355.1 EMBL· GenBank· DDBJ | mRNA | ||
AK002258 EMBL· GenBank· DDBJ | BAB21971.1 EMBL· GenBank· DDBJ | mRNA | ||
AK002394 EMBL· GenBank· DDBJ | BAB22067.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003096 EMBL· GenBank· DDBJ | BAB22562.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003472 EMBL· GenBank· DDBJ | BAB22806.1 EMBL· GenBank· DDBJ | mRNA | ||
AK005442 EMBL· GenBank· DDBJ | BAB24036.1 EMBL· GenBank· DDBJ | mRNA | ||
AK005490 EMBL· GenBank· DDBJ | BAB24075.1 EMBL· GenBank· DDBJ | mRNA | ||
AK005496 EMBL· GenBank· DDBJ | BAB24080.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010873 EMBL· GenBank· DDBJ | BAB27237.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010902 EMBL· GenBank· DDBJ | BAB27255.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010980 EMBL· GenBank· DDBJ | BAB27302.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010981 EMBL· GenBank· DDBJ | BAB27303.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010991 EMBL· GenBank· DDBJ | BAB27310.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010993 EMBL· GenBank· DDBJ | BAB27312.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011006 EMBL· GenBank· DDBJ | BAB27325.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011013 EMBL· GenBank· DDBJ | BAB27331.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011016 EMBL· GenBank· DDBJ | BAB27334.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011027 EMBL· GenBank· DDBJ | BAB27343.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011033 EMBL· GenBank· DDBJ | BAB27347.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011050 EMBL· GenBank· DDBJ | BAB27360.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011052 EMBL· GenBank· DDBJ | BAB27361.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011053 EMBL· GenBank· DDBJ | BAB27362.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011057 EMBL· GenBank· DDBJ | BAB27365.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011067 EMBL· GenBank· DDBJ | BAB27374.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011069 EMBL· GenBank· DDBJ | BAB27376.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011075 EMBL· GenBank· DDBJ | BAB27380.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011077 EMBL· GenBank· DDBJ | BAB27382.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011083 EMBL· GenBank· DDBJ | BAB27387.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011102 EMBL· GenBank· DDBJ | BAB27399.1 EMBL· GenBank· DDBJ | mRNA | ||
AK012551 EMBL· GenBank· DDBJ | BAB28311.1 EMBL· GenBank· DDBJ | mRNA | ||
AK014364 EMBL· GenBank· DDBJ | BAB29299.1 EMBL· GenBank· DDBJ | mRNA | ||
AK027903 EMBL· GenBank· DDBJ | BAC25655.1 EMBL· GenBank· DDBJ | mRNA | ||
AK027904 EMBL· GenBank· DDBJ | BAC25656.1 EMBL· GenBank· DDBJ | mRNA | ||
AK028067 EMBL· GenBank· DDBJ | BAC25734.1 EMBL· GenBank· DDBJ | mRNA | ||
AK088149 EMBL· GenBank· DDBJ | BAC40173.1 EMBL· GenBank· DDBJ | mRNA | ||
AK133714 EMBL· GenBank· DDBJ | BAE21794.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147001 EMBL· GenBank· DDBJ | BAE27598.1 EMBL· GenBank· DDBJ | mRNA | ||
AK160629 EMBL· GenBank· DDBJ | BAE35926.1 EMBL· GenBank· DDBJ | mRNA | ||
AK161021 EMBL· GenBank· DDBJ | BAE36152.1 EMBL· GenBank· DDBJ | mRNA | ||
AK165490 EMBL· GenBank· DDBJ | BAE38217.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167615 EMBL· GenBank· DDBJ | BAE39668.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168412 EMBL· GenBank· DDBJ | BAE40327.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168477 EMBL· GenBank· DDBJ | BAE40366.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168562 EMBL· GenBank· DDBJ | BAE40435.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168584 EMBL· GenBank· DDBJ | BAE40453.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168819 EMBL· GenBank· DDBJ | BAE40646.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168826 EMBL· GenBank· DDBJ | BAE40653.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168846 EMBL· GenBank· DDBJ | BAE40669.1 EMBL· GenBank· DDBJ | mRNA | ||
M19236 EMBL· GenBank· DDBJ | AAA37788.1 EMBL· GenBank· DDBJ | mRNA | ||
M10828 EMBL· GenBank· DDBJ | AAA37786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M10830 EMBL· GenBank· DDBJ | AAA37787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M10829 EMBL· GenBank· DDBJ | AAA37787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M10688 EMBL· GenBank· DDBJ | AAA37790.1 EMBL· GenBank· DDBJ | Genomic DNA |