P02016 · HBA_CYPCA

Function

function

Involved in oxygen transport from gills to the various peripheral tissues.

Features

Showing features for binding site.

114320406080100120140
TypeIDPosition(s)Description
Binding site60O2 (UniProtKB | ChEBI)
Binding site89Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentblood microparticle
Cellular Componenthaptoglobin-hemoglobin complex
Cellular Componenthemoglobin complex
Molecular Functionhaptoglobin binding
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionorganic acid binding
Molecular Functionoxygen binding
Molecular Functionoxygen carrier activity
Molecular Functionperoxidase activity
Biological Processhydrogen peroxide catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hemoglobin subunit alpha
  • Alternative names
    • Alpha-globin
    • Hemoglobin alpha chain

Gene names

    • Name
      hba

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Cyprinus

Accessions

  • Primary accession
    P02016

Proteomes

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00000526152-143Hemoglobin subunit alpha

Keywords

PTM databases

Expression

Tissue specificity

Red blood cells.

Interaction

Subunit

Heterotetramer of two alpha chains and two beta chains.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-143Globin

Sequence similarities

Belongs to the globin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    143
  • Mass (Da)
    15,447
  • Last updated
    2007-01-23 v3
  • Checksum
    19D963BC7E6AEB25
MSLSDKDKAAVKGLWAKISPKADDIGAEALGRMLTVYPQTKTYFAHWADLSPGSGPVKKHGKVIMGAVGDAVSKIDDLVGGLAALSELHAFKLRVDPANFKILAHNVIVVIGMLYPGDFPPEVHMSVDKFFQNLALALSEKYR

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict13-14in Ref. 2; AA sequence
Sequence conflict59-61in Ref. 2; AA sequence
Sequence conflict84in Ref. 2; AA sequence
Sequence conflict91in Ref. 2; AA sequence
Sequence conflict105-115in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M25643
EMBL· GenBank· DDBJ
AAA49202.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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