P01909 · DQA1_HUMAN
- ProteinHLA class II histocompatibility antigen, DQ alpha 1 chain
- GeneHLA-DQA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids254 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
GO annotations
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHLA class II histocompatibility antigen, DQ alpha 1 chain
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP01909
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein
Endosome membrane ; Single-pass type I membrane protein
Lysosome membrane ; Single-pass type I membrane protein
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 24-216 | Extracellular | ||||
Sequence: EDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSKSPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHWEPEIPAPMSELTE | ||||||
Transmembrane | 217-239 | Helical | ||||
Sequence: TVVCALGLSVGLVGIVVGTVFII | ||||||
Topological domain | 240-254 | Cytoplasmic | ||||
Sequence: RGLRSVGASRHQGPL |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_033399 | 8 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*04:01 and allele DQA1*06:01; dbSNP:rs1047989 | |||
Sequence: M → L | ||||||
Natural variant | VAR_033400 | 11 | in allele DQA1*05:05, allele DQA1*05:08 and allele DQA1*05:09; dbSNP:rs1047992 | |||
Sequence: A → T | ||||||
Natural variant | VAR_050380 | 17 | in allele DQA1*01:04 and allele DQA1*01:05; dbSNP:rs12722039 | |||
Sequence: V → M | ||||||
Natural variant | VAR_050381 | 18 | in allele DQA1*03:03; dbSNP:rs11545686 | |||
Sequence: M → T | ||||||
Natural variant | VAR_060493 | 24 | in allele DQA1*05:09; dbSNP:rs41545012 | |||
Sequence: E → K | ||||||
Natural variant | VAR_050382 | 25 | in allele DQA1*01:04 and allele DQA1*01:05; dbSNP:rs12722042 | |||
Sequence: D → G | ||||||
Natural variant | VAR_060494 | 34 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1129740 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_033401 | 41 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1071630 | |||
Sequence: S → F | ||||||
Natural variant | VAR_060495 | 44 | in allele DQA1*05:04; dbSNP:rs41549715 | |||
Sequence: P → L | ||||||
Natural variant | VAR_033402 | 48 | in allele DQA1*02:01, allele DQA1*01:03, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs12722051 | |||
Sequence: Y → F | ||||||
Natural variant | VAR_033403 | 49 | in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs1048023 | |||
Sequence: T → S | ||||||
Natural variant | VAR_014604 | 57 | in allele DQA1*01:01, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs10093 | |||
Sequence: Q → E | ||||||
Natural variant | VAR_060496 | 63 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs1142323 | |||
Sequence: G → E | ||||||
Natural variant | VAR_050383 | 64 | in allele DQA1*01:03; dbSNP:rs36219699 | |||
Sequence: R → K | ||||||
Natural variant | VAR_060497 | 67 | in allele DQA1*01:06; dbSNP:rs41543221 | |||
Sequence: T → A | ||||||
Natural variant | VAR_060498 | 68 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142324 | |||
Sequence: V → A | ||||||
Natural variant | VAR_060499 | 70 | in allele DQA1*02:01; requires 2 nucleotide substitutions | |||
Sequence: C → K | ||||||
Natural variant | VAR_060500 | 70 | in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; requires 2 nucleotide substitutions | |||
Sequence: C → Q | ||||||
Natural variant | VAR_060501 | 70 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142326 | |||
Sequence: C → R | ||||||
Natural variant | VAR_033404 | 70 | in dbSNP:rs3207983 | |||
Sequence: C → Y | ||||||
Natural variant | VAR_060502 | 71 | in allele DQA1*01:01, allele DQA1*01:02,allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142328 | |||
Sequence: L → W | ||||||
Natural variant | VAR_033406 | 73 | in dbSNP:rs760671632 | |||
Sequence: V → D | ||||||
Natural variant | VAR_060503 | 73 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs3208105 | |||
Sequence: V → E | ||||||
Natural variant | VAR_033405 | 73 | in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs12722061 | |||
Sequence: V → L | ||||||
Natural variant | VAR_060504 | 74 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs9272698 | |||
Sequence: L → F | ||||||
Natural variant | VAR_060505 | 75 | in allele DQA1*02:01; dbSNP:rs28383449 | |||
Sequence: R → H | ||||||
Natural variant | VAR_060506 | 75 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs9272699 | |||
Sequence: R → S | ||||||
Natural variant | VAR_060507 | 76 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1048052 | |||
Sequence: Q → K | ||||||
Natural variant | VAR_060508 | 76 | in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs12722069 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_060509 | 77 | in allele DQA1*02:01; dbSNP:rs3188043 | |||
Sequence: F → L | ||||||
Natural variant | VAR_060510 | 78 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs4193 | |||
Sequence: R → GG | ||||||
Natural variant | VAR_060511 | 78 | in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03 | |||
Sequence: R → RR | ||||||
Natural variant | VAR_060512 | 81 | in allele DQA1*05:02; dbSNP:rs41541412 | |||
Sequence: P → R | ||||||
Natural variant | VAR_060513 | 83 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; requires 2 nucleotide substitutions | |||
Sequence: F → G | ||||||
Natural variant | VAR_033408 | 86 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142333 | |||
Sequence: T → R | ||||||
Natural variant | VAR_033409 | 88 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142334 | |||
Sequence: I → M | ||||||
Natural variant | VAR_060514 | 91 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; requires 2 nucleotide substitutions | |||
Sequence: L → A | ||||||
Natural variant | VAR_060515 | 91 | in allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; requires 2 nucleotide substitutions | |||
Sequence: L → T | ||||||
Natural variant | VAR_060516 | 97 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs9279910 | |||
Sequence: S → I | ||||||
Natural variant | VAR_060517 | 98 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1064944 | |||
Sequence: L → M | ||||||
Natural variant | VAR_060518 | 98 | in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs1064944 | |||
Sequence: L → V | ||||||
Natural variant | VAR_060519 | 101 | in allele DQA1*01:07; dbSNP:rs41542116 | |||
Sequence: R → C | ||||||
Natural variant | VAR_050384 | 102 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1129808 | |||
Sequence: S → Y | ||||||
Natural variant | VAR_060520 | 124 | in allele DQA1*05:06; dbSNP:rs41555012 | |||
Sequence: L → V | ||||||
Natural variant | VAR_050385 | 129 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs707952 | |||
Sequence: I → T | ||||||
Natural variant | VAR_050386 | 151 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07; dbSNP:rs707950 | |||
Sequence: H → Q | ||||||
Natural variant | VAR_060521 | 152 | in allele DQA1*01:03; dbSNP:rs41547417 | |||
Sequence: S → A | ||||||
Natural variant | VAR_060522 | 160 | in allele DQA1*04:02; dbSNP:rs41545514 | |||
Sequence: T → I | ||||||
Natural variant | VAR_060524 | 161 | in allele DQA1*05:08; dbSNP:rs41544114 | |||
Sequence: S → I | ||||||
Natural variant | VAR_060523 | 161 | in allele DQA1*06:02; dbSNP:rs41552014 | |||
Sequence: S → R | ||||||
Natural variant | VAR_060525 | 175 | in allele DQA1*04:04; dbSNP:rs41550317 | |||
Sequence: Y → H | ||||||
Natural variant | VAR_060526 | 178 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs707949 | |||
Sequence: L → F | ||||||
Natural variant | VAR_060527 | 182 | in allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs7990 | |||
Sequence: A → D | ||||||
Natural variant | VAR_060528 | 182 | in allele DQA1*05:03, allele DQA1*05:06 and allele DQA1*05:07; dbSNP:rs41561312 | |||
Sequence: A → S | ||||||
Natural variant | VAR_060529 | 183 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs707963 | |||
Sequence: E → D | ||||||
Natural variant | VAR_060530 | 185 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs707962 | |||
Sequence: S → I | ||||||
Natural variant | VAR_060531 | 197 | in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs2308891 | |||
Sequence: K → E | ||||||
Natural variant | VAR_060532 | 197 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07; dbSNP:rs2308891 | |||
Sequence: K → Q | ||||||
Natural variant | VAR_050387 | 209 | in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs9272785 | |||
Sequence: A → T | ||||||
Natural variant | VAR_050388 | 221 | in allele DQA1*01:04; dbSNP:rs35087390 | |||
Sequence: A → T | ||||||
Natural variant | VAR_033411 | 229 | in allele DQA1*01:02; dbSNP:rs9260 | |||
Sequence: V → M | ||||||
Natural variant | VAR_060533 | 230 | in allele DQA1*05:07; dbSNP:rs41545416 | |||
Sequence: G → C | ||||||
Natural variant | VAR_033412 | 237 | in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs1048430 | |||
Sequence: F → L | ||||||
Natural variant | VAR_033413 | 240 | in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04 and allele DQA1*01:05; dbSNP:rs1048439 | |||
Sequence: R → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 321 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MILNKALMLGALALTTVMSPCGG | ||||||
Chain | PRO_0000018970 | 24-254 | HLA class II histocompatibility antigen, DQ alpha 1 chain | |||
Sequence: EDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSKSPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTVFIIRGLRSVGASRHQGPL | ||||||
Glycosylation | 103 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 132↔188 | |||||
Sequence: CLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDC | ||||||
Glycosylation | 143 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P01909 | HLA-DQB1 P01920 | 9 | EBI-713389, EBI-1038012 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 24-119 | Alpha-1 | ||||
Sequence: EDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSK | ||||||
Domain | 112-204 | Ig-like C1-type | ||||
Sequence: PEVTVFSKSPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHWE | ||||||
Region | 120-203 | Alpha-2 | ||||
Sequence: SPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHW | ||||||
Region | 204-216 | Connecting peptide | ||||
Sequence: EPEIPAPMSELTE |
Sequence similarities
Belongs to the MHC class II family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length254
- Mass (Da)27,805
- Last updated1986-07-21 v1
- Checksum84E12B5A80E2A028
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5Y7H0 | Q5Y7H0_HUMAN | HLA-DQA1 | 255 | ||
A0A182DWF8 | A0A182DWF8_HUMAN | HLA-DQA1 | 24 | ||
A0A182DWH0 | A0A182DWH0_HUMAN | HLA-DQA1 | 24 | ||
A0A182DWH1 | A0A182DWH1_HUMAN | HLA-DQA1 | 24 | ||
A0A1W2PP70 | A0A1W2PP70_HUMAN | HLA-DQA1 | 190 | ||
E9PMV2 | E9PMV2_HUMAN | HLA-DQA1 | 214 | ||
E9PI37 | E9PI37_HUMAN | HLA-DQA1 | 53 | ||
A0A140TA20 | A0A140TA20_HUMAN | HLA-DQA1 | 41 | ||
F6UB03 | F6UB03_HUMAN | HLA-DQA1 | 24 | ||
A0A0G2JKJ3 | A0A0G2JKJ3_HUMAN | HLA-DQA1 | 115 | ||
Q08AS3 | Q08AS3_HUMAN | HLA-DQA1 | 254 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 11 | in Ref. 4; AAA59760 | ||||
Sequence: A → S | ||||||
Sequence conflict | 23-27 | in Ref. 16; AAA59754 | ||||
Sequence: Missing | ||||||
Sequence conflict | 91 | in Ref. 4; AAA59760 | ||||
Sequence: L → H | ||||||
Sequence conflict | 107 | in Ref. 16; AAA59754 | ||||
Sequence: A → P | ||||||
Sequence conflict | 156 | in Ref. 3; CAA25141 | ||||
Sequence: G → D | ||||||
Sequence conflict | 213 | in Ref. 16; AAA59754 | ||||
Sequence: E → D |
Polymorphism
The following alleles of DQA1 are known: DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:03, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*06:01, DQA1*06:02. The sequence shown is that of DQA1*05:01.
DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02). DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X00033 EMBL· GenBank· DDBJ | CAA24917.1 EMBL· GenBank· DDBJ | mRNA | ||
X00370 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
X00452 EMBL· GenBank· DDBJ | CAA25141.1 EMBL· GenBank· DDBJ | mRNA | ||
M16995 EMBL· GenBank· DDBJ | AAA59760.1 EMBL· GenBank· DDBJ | mRNA | ||
U92032 EMBL· GenBank· DDBJ | AAB91990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY663395 EMBL· GenBank· DDBJ | AAU87978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY663398 EMBL· GenBank· DDBJ | AAU87987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY663400 EMBL· GenBank· DDBJ | AAU87992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY663406 EMBL· GenBank· DDBJ | AAU88007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY663411 EMBL· GenBank· DDBJ | AAU88022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY663413 EMBL· GenBank· DDBJ | AAU88028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178403 EMBL· GenBank· DDBJ | ABA86855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178400 EMBL· GenBank· DDBJ | ABA86855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178401 EMBL· GenBank· DDBJ | ABA86855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178402 EMBL· GenBank· DDBJ | ABA86855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178407 EMBL· GenBank· DDBJ | ABA86856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178404 EMBL· GenBank· DDBJ | ABA86856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178405 EMBL· GenBank· DDBJ | ABA86856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178406 EMBL· GenBank· DDBJ | ABA86856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178411 EMBL· GenBank· DDBJ | ABA86857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178408 EMBL· GenBank· DDBJ | ABA86857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178409 EMBL· GenBank· DDBJ | ABA86857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178410 EMBL· GenBank· DDBJ | ABA86857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178415 EMBL· GenBank· DDBJ | ABA86858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178412 EMBL· GenBank· DDBJ | ABA86858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178413 EMBL· GenBank· DDBJ | ABA86858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ178414 EMBL· GenBank· DDBJ | ABA86858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M29616 EMBL· GenBank· DDBJ | AAA59759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M29613 EMBL· GenBank· DDBJ | AAA59759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF322870 EMBL· GenBank· DDBJ | AAK11577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF322867 EMBL· GenBank· DDBJ | AAK11577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF322868 EMBL· GenBank· DDBJ | AAK11577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF322869 EMBL· GenBank· DDBJ | AAK11577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF395700 EMBL· GenBank· DDBJ | AAM69677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF395697 EMBL· GenBank· DDBJ | AAM69677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF395698 EMBL· GenBank· DDBJ | AAM69677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF395699 EMBL· GenBank· DDBJ | AAM69677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR450297 EMBL· GenBank· DDBJ | CAG29293.1 EMBL· GenBank· DDBJ | mRNA | ||
AM042559 EMBL· GenBank· DDBJ | CAJ14960.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM042560 EMBL· GenBank· DDBJ | CAJ14961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK313975 EMBL· GenBank· DDBJ | BAG36689.1 EMBL· GenBank· DDBJ | mRNA | ||
BX248406 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL662789 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z84489 EMBL· GenBank· DDBJ | CAB06491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC008585 EMBL· GenBank· DDBJ | AAH08585.1 EMBL· GenBank· DDBJ | mRNA | ||
BC157865 EMBL· GenBank· DDBJ | AAI57866.1 EMBL· GenBank· DDBJ | mRNA | ||
L46875 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
L46876 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
L46877 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
L46878 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
L46880 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
L46881 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
M11124 EMBL· GenBank· DDBJ | AAA59754.1 EMBL· GenBank· DDBJ | mRNA | ||
M20431 EMBL· GenBank· DDBJ | AAA59758.1 EMBL· GenBank· DDBJ | mRNA | ||
L34082 EMBL· GenBank· DDBJ | AAC41950.1 EMBL· GenBank· DDBJ | mRNA | ||
L34085 EMBL· GenBank· DDBJ | AAC41953.1 EMBL· GenBank· DDBJ | mRNA | ||
L34086 EMBL· GenBank· DDBJ | AAC41954.1 EMBL· GenBank· DDBJ | mRNA | ||
L34089 EMBL· GenBank· DDBJ | AAC41957.1 EMBL· GenBank· DDBJ | mRNA | ||
L34090 EMBL· GenBank· DDBJ | AAC41958.1 EMBL· GenBank· DDBJ | mRNA | ||
L34092 EMBL· GenBank· DDBJ | AAC41960.1 EMBL· GenBank· DDBJ | mRNA | ||
L34093 EMBL· GenBank· DDBJ | AAC41961.1 EMBL· GenBank· DDBJ | mRNA | ||
L34094 EMBL· GenBank· DDBJ | AAC41962.1 EMBL· GenBank· DDBJ | mRNA | ||
L42625 EMBL· GenBank· DDBJ | AAA85334.1 EMBL· GenBank· DDBJ | mRNA | ||
AY197775 EMBL· GenBank· DDBJ | AAO45622.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY547314 EMBL· GenBank· DDBJ | AAS49496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY206406 EMBL· GenBank· DDBJ | AAO47362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY585236 EMBL· GenBank· DDBJ | AAT09985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34997 EMBL· GenBank· DDBJ | AAA35772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34999 EMBL· GenBank· DDBJ | AAA74633.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U85035 EMBL· GenBank· DDBJ | AAB41891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF109734 EMBL· GenBank· DDBJ | AAD56720.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
U03675 EMBL· GenBank· DDBJ | AAB60341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M20506 EMBL· GenBank· DDBJ | AAA59774.1 EMBL· GenBank· DDBJ | mRNA | ||
J00199 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
M17846 EMBL· GenBank· DDBJ | AAA59707.1 EMBL· GenBank· DDBJ | mRNA |