Molecular programming of B cell memory.McHeyzer-Williams M., Okitsu S., Wang N., McHeyzer-Williams L.View abstractCited forREVIEW ON FUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Rev. Immunol. 12:24-34 (2012)Cited in99+
The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE.Vonakis B.M., Chen H., Haleem-Smith H., Metzger H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ. Biol. Chem. 272:24072-24080 (1997)Cited in1Mapped to90
Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.Harmer S.L., DeFranco A.L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCMol Cell Biol 17:4087-4095 (1997)Mapped to99+
SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.Hendricks-Taylor L.R., Motto D.G., Zhang J., Siraganian R.P., Koretzky G.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Biol Chem 272:1363-1367 (1997)Mapped to99
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.Kimura T., Kihara H., Bhattacharyya S., Sakamoto H., Appella E., Siraganian R.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Biol Chem 271:27962-27968 (1996)Mapped to99+
Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.Bubeck Wardenburg J., Fu C., Jackman J.K., Flotow H., Wilkinson S.E., Williams D.H., Johnson R., Kong G., Chan A.C., Findell P.R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ. Biol. Chem. 271:19641-19644 (1996)Cited in2Mapped to99+
Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2.Jabril-Cuenod B., Zhang C., Scharenberg A.M., Paolini R., Numerof R., Beaven M.A., Kinet J.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Biol Chem 271:16268-16272 (1996)Mapped to95
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.Park H., Wahl M.I., Afar D.E., Turck C.W., Rawlings D.J., Tam C., Scharenberg A.M., Kinet J.P., Witte O.N.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCImmunity 4:515-525 (1996)Cited in2Mapped to99+
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.Rawlings D.J., Scharenberg A.M., Park H., Wahl M.I., Lin S., Kato R.M., Fluckiger A.C., Witte O.N., Kinet J.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCScience 271:822-825 (1996)Cited in2Mapped to99+
Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.Kihara H., Siraganian R.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Biol Chem 269:22427-22432 (1994)Mapped to91
Interaction of p72syk with the gamma and beta subunits of the high- affinity receptor for immunoglobulin E, Fc epsilon RI.Shiue L., Green J., Green O.M., Karas J.L., Morgenstern J.P., Ram M.K., Taylor M.K., Zoller M.J., Zydowsky L.D., Bolen J.B.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCMol Cell Biol 15:272-281 (1995)Mapped to91
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.Pribluda V.S., Pribluda C., Metzger H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCProc Natl Acad Sci U S A 91:11246-11250 (1994)Mapped to90
Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.Kawakami Y., Yao L., Miura T., Tsukada S., Witte O.N., Kawakami T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCMol Cell Biol 14:5108-5113 (1994)Mapped to99+
Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects.Arm J.P., Bottoli I., Skerjanec A., Floch D., Groenewegen A., Maahs S., Owen C.E., Jones I., Lowe P.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCClin Exp Allergy 44:1371-1385 (2014)Mapped to86
Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Gresset A., Hicks S.N., Harden T.K., Sondek J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Biol Chem 285:35836-35847 (2010)Mapped to99+
SLP-76 couples Syk to the osteoclast cytoskeleton.Reeve J.L., Zou W., Liu Y., Maltzman J.S., Ross F.P., Teitelbaum S.L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Immunol 183:1804-1812 (2009)Mapped to99+
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.Iwaki S., Spicka J., Tkaczyk C., Jensen B.M., Furumoto Y., Charles N., Kovarova M., Rivera J., Horejsi V.[...], Gilfillan A.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCCell Signal 20:195-205 (2008)Mapped to99+
Insights into immunoglobulin E receptor signaling from structurally defined ligands.Holowka D., Sil D., Torigoe C., Baird B.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCImmunol Rev 217:269-279 (2007)Mapped to89
Selective function of PKC-theta in T cells.Manicassamy S., Gupta S., Sun Z.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCCell. Mol. Immunol. 3:263-270 (2006)Cited in1Mapped to99+
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.Jiang Y., Cheng H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCLeuk Res 31:541-545 (2007)Mapped to99+
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.Yu M., Lowell C.A., Neel B.G., Gu H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ. Immunol. 176:2421-2429 (2006)Cited in2Mapped to99+
Omalizumab (Xolair) for treatment of asthma.Davydov L.AnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCAm Fam Physician 71:341-342 (2005)Mapped to86
Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.Humphries L.A., Dangelmaier C., Sommer K., Kipp K., Kato R.M., Griffith N., Bakman I., Turk C.W., Daniel J.L., Rawlings D.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCJ Biol Chem 279:37651-37661 (2004)Mapped to99+
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.Tkaczyk C., Horejsi V., Iwaki S., Draber P., Samelson L.E., Satterthwaite A.B., Nahm D.H., Metcalfe D.D., Gilfillan A.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCBlood 104:207-214 (2004)Cited in1Mapped to91
Mast cell signal transduction from the high-affinity IgE receptor.Siraganian R.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-1478806PubMedEurope PMCCurr Opin Immunol 15:639-646 (2003)Mapped to89