P01572 · IFNA1_MOUSE

  • Protein
    Interferon alpha-1
  • Gene
    Ifna1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Caution

Was named interferon alpha-E (embryonic) based on peptide sequencing (PubMed:9244179).
The differences found may be sequencing erros and have not been confirmed by other studies

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functiontype I interferon receptor binding
Biological Processadaptive immune response
Biological ProcessB cell differentiation
Biological ProcessB cell proliferation
Biological Processcytokine-mediated signaling pathway
Biological Processdefense response to bacterium
Biological Processdefense response to virus
Biological Processhumoral immune response
Biological Processnatural killer cell activation involved in immune response
Biological Processpositive regulation of peptidyl-serine phosphorylation of STAT protein
Biological Processregulation of defense response to virus by host
Biological Processresponse to exogenous dsRNA
Biological ProcessT cell activation involved in immune response
Biological Processtype I interferon-mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interferon alpha-1
  • Short names
    IFN-alpha-1

Gene names

    • Name
      Ifna1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P01572
  • Secondary accessions
    • Q7M0A3
    • Q810G7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, disulfide bond, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-23
Disulfide bond24↔122
ChainPRO_000001637524-189Interferon alpha-1
Disulfide bond52↔162
Glycosylation101N-linked (GlcNAc...) asparagine

Post-translational modification

Glycosylated.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with CR2.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the alpha/beta interferon family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    189
  • Mass (Da)
    21,646
  • Last updated
    2011-02-08 v2
  • Checksum
    D6F4BC96DCE7D67E
MARLCAFLMVLAVLSYWPTCSLGCDLPQTHNLRNKRALTLLVQMRRLSPLSCLKDRKDFGFPQEKVDAQQIKKAQAIPVLSELTQQILNIFTSKDSSAAWNTTLLDSFCNDLHQQLNDLQGCLMQQVGVQEFPLTQEDALLAVRKYFHRITVYLREKKHSPCAWEVVRAEVWRALSSSANVLGRLREEK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict14in Ref. 1; no nucleotide entry and 2; CAA26006
Sequence conflict102in Ref. 1; no nucleotide entry and 2; CAA26006
Sequence conflict126in Ref. 6; AA sequence
Sequence conflict132in Ref. 6; AA sequence
Sequence conflict139in Ref. 6; AA sequence
Sequence conflict145in Ref. 6; AA sequence
Sequence conflict175in Ref. 6; AA sequence
Sequence conflict180-181in Ref. 6; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X01974
EMBL· GenBank· DDBJ
CAA26006.1
EMBL· GenBank· DDBJ
Genomic DNA
AY225950
EMBL· GenBank· DDBJ
AAO63592.1
EMBL· GenBank· DDBJ
Genomic DNA
BX530016
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466527
EMBL· GenBank· DDBJ
EDL30958.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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