IFNA21 may be involved in inflammatory processes in an age-dependent manner and in progression of coronary artery disease. Several 9p21 SNPs may modulate inflammatory processes mediated by IFNA21 and may therefore contribute to pathophysiology of coronary artery disease.
Structural AA changes in the C-helix interacting with IFNAlphaR1 may change the signaling dynamics leading to elevated APOBEC3 & lower IDO by an engineered mutant derived from the amino-terminal region of IFNalpha21b and the COOH-terminus from IFNalpha2c.
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