P01563 · IFNA2_HUMAN
- ProteinInterferon alpha-2
- GeneIFNA2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids188 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Produced by macrophages, IFN-alpha have antiviral activities.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameInterferon alpha-2
- Short namesIFN-alpha-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP01563
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Pharmaceutical
Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_055972 | 6 | in dbSNP:rs35971916 | |||
Sequence: A → D | ||||||
Natural variant | VAR_004012 | 46 | in allele alpha-2A; dbSNP:rs1061959 | |||
Sequence: R → K | ||||||
Natural variant | VAR_013001 | 57 | in allele alpha-2C; dbSNP:rs73420190 | |||
Sequence: H → R | ||||||
Natural variant | VAR_036329 | 177 | in a breast cancer sample; somatic mutation | |||
Sequence: S → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 270 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
Protein family/group databases
PTM/Processing
Features
Showing features for signal, disulfide bond, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MALTFALLVALLVLSCKSSCSVG | ||||||
Disulfide bond | 24↔121 | |||||
Sequence: CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEAC | ||||||
Chain | PRO_0000016360 | 24-188 | Interferon alpha-2 | |||
Sequence: CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE | ||||||
Disulfide bond | 52↔161 | |||||
Sequence: CLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPC | ||||||
Glycosylation | CAR_000049 | 129 | O-linked (GalNAc...) threonine | |||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with IFNAR2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P01563 | IFNAR2 P48551 | 2 | EBI-4394394, EBI-958408 | |
BINARY | P01563 | TIMMDC1 Q9NPL8 | 3 | EBI-4394394, EBI-6268651 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length188
- Mass (Da)21,578
- Last updated2022-05-25 v2
- Checksum9BAA221D2BFB421D
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 85 | in Ref. 6; AEX60803 | ||||
Sequence: Q → L | ||||||
Sequence conflict | 93 | in Ref. 6; AEX60802 | ||||
Sequence: K → M |
Polymorphism
Three alleles exist; alpha-2A, alpha-2B (shown here) and alpha-2C (PubMed:7627809).
Allele alpha-2B is the predominant allele while allele alpha-2A is less predominant and alpha-2C only a minor allelic variant
Allele alpha-2B is the predominant allele while allele alpha-2A is less predominant and alpha-2C only a minor allelic variant
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J00207 EMBL· GenBank· DDBJ | AAB59402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
V00544 EMBL· GenBank· DDBJ | CAA23805.1 EMBL· GenBank· DDBJ | mRNA | ||
V00548 EMBL· GenBank· DDBJ | CAA23809.1 EMBL· GenBank· DDBJ | mRNA | ||
V00549 EMBL· GenBank· DDBJ | CAA23810.1 EMBL· GenBank· DDBJ | mRNA | ||
Y11834 EMBL· GenBank· DDBJ | CAA72532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN591568 EMBL· GenBank· DDBJ | AEX60802.1 EMBL· GenBank· DDBJ | mRNA | ||
JN591569 EMBL· GenBank· DDBJ | AEX60803.1 EMBL· GenBank· DDBJ | mRNA | ||
JN591570 EMBL· GenBank· DDBJ | AEX60804.1 EMBL· GenBank· DDBJ | mRNA | ||
JN848522 EMBL· GenBank· DDBJ | AET86951.1 EMBL· GenBank· DDBJ | mRNA | ||
CR541921 EMBL· GenBank· DDBJ | CAG46719.1 EMBL· GenBank· DDBJ | mRNA | ||
AL353732 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471071 EMBL· GenBank· DDBJ | EAW58611.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC074936 EMBL· GenBank· DDBJ | AAH74936.1 EMBL· GenBank· DDBJ | mRNA | ||
BC074937 EMBL· GenBank· DDBJ | AAH74937.1 EMBL· GenBank· DDBJ | mRNA | ||
BC104163 EMBL· GenBank· DDBJ | AAI04164.1 EMBL· GenBank· DDBJ | mRNA | ||
BC104164 EMBL· GenBank· DDBJ | AAI04165.1 EMBL· GenBank· DDBJ | mRNA | ||
M54886 EMBL· GenBank· DDBJ | AAA59181.1 EMBL· GenBank· DDBJ | mRNA | ||
M29883 EMBL· GenBank· DDBJ | AAA52715.1 EMBL· GenBank· DDBJ | Genomic DNA |