P01242 · SOM2_HUMAN
- ProteinGrowth hormone variant
- GeneGH2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids217 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome lumen | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Molecular Function | growth factor activity | |
Molecular Function | growth hormone receptor binding | |
Molecular Function | hormone activity | |
Biological Process | animal organ development | |
Biological Process | growth hormone receptor signaling pathway | |
Biological Process | positive regulation of growth | |
Biological Process | positive regulation of receptor signaling pathway via JAK-STAT | |
Biological Process | positive regulation of tyrosine phosphorylation of STAT protein | |
Biological Process | response to nutrient levels |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGrowth hormone variant
- Short namesGH-V
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP01242
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_014591 | 90 | in dbSNP:rs5389 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 331 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MAAGSRTSLLLAFGLLCLSWLQEGSA | ||||||
Chain | PRO_0000033061 | 27-217 | Growth hormone variant | |||
Sequence: FPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF | ||||||
Disulfide bond | 79↔191 | |||||
Sequence: CFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYC | ||||||
Modified residue | 132 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 166 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 176 | Phosphoserine | ||||
Sequence: S | ||||||
Disulfide bond | 208↔215 | |||||
Sequence: CRSVEGSC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the placenta.
Gene expression databases
Organism-specific databases
Interaction
Structure
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 4 isoforms produced by Alternative splicing.
P01242-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsGH-V1
- Length217
- Mass (Da)25,000
- Last updated2002-03-27 v3
- Checksum7B9324698E822F96
P01242-2
- Name2
- SynonymsGH-V2
- Differences from canonical
- 153-217: RLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF → VRVAPGIPNPGAPLASRDWGEKHCCPLFSSQALTQENSPYSSFPLVNPPGLSLQPGGEGGKWMNERGREQCPSAWPLLLFLHFAEAGRWQPPDWADLQSVLQQV
P01242-3
- Name3
- Differences from canonical
- 58-72: Missing
P01242-4
- Name4
- Differences from canonical
- 151-217: MWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF → IGWKMAAPGLGRSSISPTASLTQNRTTMTHCSRTTGCSTASGRTWTRSRHSCASCSAALWRAAVASSCPGGIPVTPPQCLSWSWKVLLQCPPALS
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WXJ5 | A0A087WXJ5_HUMAN | GH2 | 177 |
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 44 | in Ref. 12; AA sequence | ||||
Sequence: Missing | ||||||
Alternative sequence | VSP_043206 | 58-72 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 109 | in Ref. 2; AAB59547/AAB59548 | ||||
Sequence: I → T | ||||||
Alternative sequence | VSP_043480 | 151-217 | in isoform 4 | |||
Sequence: MWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF → IGWKMAAPGLGRSSISPTASLTQNRTTMTHCSRTTGCSTASGRTWTRSRHSCASCSAALWRAAVASSCPGGIPVTPPQCLSWSWKVLLQCPPALS | ||||||
Alternative sequence | VSP_006203 | 153-217 | in isoform 2 | |||
Sequence: RLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF → VRVAPGIPNPGAPLASRDWGEKHCCPLFSSQALTQENSPYSSFPLVNPPGLSLQPGGEGGKWMNERGREQCPSAWPLLLFLHFAEAGRWQPPDWADLQSVLQQV |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
K00470 EMBL· GenBank· DDBJ | AAA98619.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
J03756 EMBL· GenBank· DDBJ | AAB59547.1 EMBL· GenBank· DDBJ | mRNA | ||
J03756 EMBL· GenBank· DDBJ | AAB59548.1 EMBL· GenBank· DDBJ | mRNA | ||
M38451 EMBL· GenBank· DDBJ | AAA35891.1 EMBL· GenBank· DDBJ | mRNA | ||
J03071 EMBL· GenBank· DDBJ | AAA52552.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF006060 EMBL· GenBank· DDBJ | AAB71828.1 EMBL· GenBank· DDBJ | mRNA | ||
AF006061 EMBL· GenBank· DDBJ | AAB71829.1 EMBL· GenBank· DDBJ | mRNA | ||
EU421715 EMBL· GenBank· DDBJ | ABZ88719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU421715 EMBL· GenBank· DDBJ | ABZ88720.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU421715 EMBL· GenBank· DDBJ | ABZ88721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU421715 EMBL· GenBank· DDBJ | ABZ88722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK312194 EMBL· GenBank· DDBJ | BAG35127.1 EMBL· GenBank· DDBJ | mRNA | ||
AB451332 EMBL· GenBank· DDBJ | BAG70146.1 EMBL· GenBank· DDBJ | mRNA | ||
AB451477 EMBL· GenBank· DDBJ | BAG70291.1 EMBL· GenBank· DDBJ | mRNA | ||
AC040958 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471109 EMBL· GenBank· DDBJ | EAW94238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471109 EMBL· GenBank· DDBJ | EAW94248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471109 EMBL· GenBank· DDBJ | EAW94252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471109 EMBL· GenBank· DDBJ | EAW94258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC020760 EMBL· GenBank· DDBJ | AAH20760.1 EMBL· GenBank· DDBJ | mRNA |