P01242 · SOM2_HUMAN

  • Protein
    Growth hormone variant
  • Gene
    GH2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome lumen
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functiongrowth factor activity
Molecular Functiongrowth hormone receptor binding
Molecular Functionhormone activity
Biological Processanimal organ development
Biological Processgrowth hormone receptor signaling pathway
Biological Processpositive regulation of growth
Biological Processpositive regulation of receptor signaling pathway via JAK-STAT
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processresponse to nutrient levels

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Growth hormone variant
  • Short names
    GH-V
  • Alternative names
    • Growth hormone 2
    • Placenta-specific growth hormone

Gene names

    • Name
      GH2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P01242
  • Secondary accessions
    • B1A4H5
    • B1A4H7
    • O14643
    • O14644
    • P09587

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_01459190in dbSNP:rs5389

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 331 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000003306127-217Growth hormone variant
Disulfide bond79↔191
Modified residue132Phosphoserine
Glycosylation166N-linked (GlcNAc...) asparagine
Modified residue176Phosphoserine
Disulfide bond208↔215

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the placenta.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the somatotropin/prolactin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 4 isoforms produced by Alternative splicing.

P01242-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    GH-V1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    217
  • Mass (Da)
    25,000
  • Last updated
    2002-03-27 v3
  • Checksum
    7B9324698E822F96
MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

P01242-2

  • Name
    2
  • Synonyms
    GH-V2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 153-217: RLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF → VRVAPGIPNPGAPLASRDWGEKHCCPLFSSQALTQENSPYSSFPLVNPPGLSLQPGGEGGKWMNERGREQCPSAWPLLLFLHFAEAGRWQPPDWADLQSVLQQV

P01242-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P01242-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 151-217: MWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF → IGWKMAAPGLGRSSISPTASLTQNRTTMTHCSRTTGCSTASGRTWTRSRHSCASCSAALWRAAVASSCPGGIPVTPPQCLSWSWKVLLQCPPALS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087WXJ5A0A087WXJ5_HUMANGH2177

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict44in Ref. 12; AA sequence
Alternative sequenceVSP_04320658-72in isoform 3
Sequence conflict109in Ref. 2; AAB59547/AAB59548
Alternative sequenceVSP_043480151-217in isoform 4
Alternative sequenceVSP_006203153-217in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
K00470
EMBL· GenBank· DDBJ
AAA98619.1
EMBL· GenBank· DDBJ
Genomic DNA
J03756
EMBL· GenBank· DDBJ
AAB59547.1
EMBL· GenBank· DDBJ
mRNA
J03756
EMBL· GenBank· DDBJ
AAB59548.1
EMBL· GenBank· DDBJ
mRNA
M38451
EMBL· GenBank· DDBJ
AAA35891.1
EMBL· GenBank· DDBJ
mRNA
J03071
EMBL· GenBank· DDBJ
AAA52552.1
EMBL· GenBank· DDBJ
Genomic DNA
AF006060
EMBL· GenBank· DDBJ
AAB71828.1
EMBL· GenBank· DDBJ
mRNA
AF006061
EMBL· GenBank· DDBJ
AAB71829.1
EMBL· GenBank· DDBJ
mRNA
EU421715
EMBL· GenBank· DDBJ
ABZ88719.1
EMBL· GenBank· DDBJ
Genomic DNA
EU421715
EMBL· GenBank· DDBJ
ABZ88720.1
EMBL· GenBank· DDBJ
Genomic DNA
EU421715
EMBL· GenBank· DDBJ
ABZ88721.1
EMBL· GenBank· DDBJ
Genomic DNA
EU421715
EMBL· GenBank· DDBJ
ABZ88722.1
EMBL· GenBank· DDBJ
Genomic DNA
AK312194
EMBL· GenBank· DDBJ
BAG35127.1
EMBL· GenBank· DDBJ
mRNA
AB451332
EMBL· GenBank· DDBJ
BAG70146.1
EMBL· GenBank· DDBJ
mRNA
AB451477
EMBL· GenBank· DDBJ
BAG70291.1
EMBL· GenBank· DDBJ
mRNA
AC040958
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471109
EMBL· GenBank· DDBJ
EAW94238.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471109
EMBL· GenBank· DDBJ
EAW94248.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471109
EMBL· GenBank· DDBJ
EAW94252.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471109
EMBL· GenBank· DDBJ
EAW94258.1
EMBL· GenBank· DDBJ
Genomic DNA
BC020760
EMBL· GenBank· DDBJ
AAH20760.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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