P01179 · NEU1_RAT

  • Protein
    Oxytocin-neurophysin 1
  • Gene
    Oxt
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentneuronal dense core vesicle
Cellular Componentsecretory granule
Cellular Componentterminal bouton
Molecular Functionneurohypophyseal hormone activity
Molecular Functionneuropeptide hormone activity
Molecular Functionoxytocin receptor binding
Molecular FunctionV1A vasopressin receptor binding
Biological Processdrinking behavior
Biological Processeating behavior
Biological Processfemale pregnancy
Biological Processgrooming behavior
Biological Processheart development
Biological Processlactation
Biological Processmale mating behavior
Biological Processmaternal aggressive behavior
Biological Processmaternal behavior
Biological Processmemory
Biological Processnegative regulation of blood pressure
Biological Processnegative regulation of urine volume
Biological Processparturition
Biological Processpositive regulation of blood pressure
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of female receptivity
Biological Processpositive regulation of hindgut contraction
Biological Processpositive regulation of norepinephrine secretion
Biological Processpositive regulation of ossification
Biological Processpositive regulation of penile erection
Biological Processpositive regulation of prostaglandin secretion
Biological Processpositive regulation of synapse assembly
Biological Processpositive regulation of synaptic transmission
Biological Processpositive regulation of uterine smooth muscle contraction
Biological Processregulation of heart rate
Biological Processresponse to activity
Biological Processresponse to amphetamine
Biological Processresponse to cAMP
Biological Processresponse to cocaine
Biological Processresponse to electrical stimulus
Biological Processresponse to estradiol
Biological Processresponse to ether
Biological Processresponse to external biotic stimulus
Biological Processresponse to food
Biological Processresponse to glucocorticoid
Biological Processresponse to mechanical stimulus
Biological Processresponse to organic cyclic compound
Biological Processresponse to peptide hormone
Biological Processresponse to progesterone
Biological Processresponse to prostaglandin E
Biological Processresponse to retinoic acid
Biological Processresponse to steroid hormone
Biological Processresponse to sucrose
Biological Processsocial behavior
Biological Processsperm ejaculation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxytocin-neurophysin 1
  • Short names
    OT-NPI
  • Cleaved into 2 chains

Gene names

    • Name
      Oxt
    • Synonyms
      Ot

Organism names

  • Taxonomic identifier
  • Strain
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P01179
  • Secondary accessions
    • Q53WU2

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, disulfide bond, peptide, modified residue, chain.

TypeIDPosition(s)Description
Signal1-19
Disulfide bond20↔25
PeptidePRO_000002050320-28Oxytocin
Modified residue28Glycine amide
ChainPRO_000002050432-125Neurophysin 1
Disulfide bond41↔85
Disulfide bond44↔58
Disulfide bond52↔75
Disulfide bond59↔65
Disulfide bond92↔104
Disulfide bond98↔116
Disulfide bond105↔110

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the vasopressin/oxytocin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    125
  • Mass (Da)
    12,823
  • Last updated
    1989-07-01 v2
  • Checksum
    DC98F90BADC5551F
MACPSLACCLLGLLALTSACYIQNCPLGGKRAALDLDMRKCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCATAGICCSPDGCRTDPACDPESAFSER

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict100in Ref. 6; AA sequence
Sequence conflict124-125in Ref. 5; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
K01701
EMBL· GenBank· DDBJ
AAA98733.1
EMBL· GenBank· DDBJ
Genomic DNA
M25649
EMBL· GenBank· DDBJ
AAA41773.1
EMBL· GenBank· DDBJ
mRNA
X12792
EMBL· GenBank· DDBJ
CAA31281.1
EMBL· GenBank· DDBJ
Genomic DNA
X59496
EMBL· GenBank· DDBJ
CAA42085.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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