Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.Cacace A.M., Michaud N.R., Therrien M., Mathes K., Copeland T., Rubin G.M., Morrison D.K.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCMol Cell Biol 19:229-240 (1999)Mapped to49
Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation.Raffioni S., Zhu Y.Z., Bradshaw R.A., Thompson L.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCJ Biol Chem 273:35250-35259 (1998)Mapped to28
Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease.Chen Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647782, Reactome: R-HSA-9647928PubMedEurope PMCCancer Lett 131:191-200 (1998)Mapped to4
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.King A.J., Sun H., Diaz B., Barnard D., Miao W., Bagrodia S., Marshall M.S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCNature 396:180-183 (1998)Cited in1Mapped to21
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.Zhang B., Zheng Y.View abstractCategoriesInteractionSourceIntAct: P01111PubMedEurope PMCJ Biol Chem 273:25728-25733 (1998)Mapped to5
Signal transduction via platelet-derived growth factor receptors.Heldin C.H., Ostman A., Ronnstrand L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCBiochim. Biophys. Acta 1378:F79-113 (1998)Cited in2Mapped to27
The structural basis of the activation of Ras by Sos.Boriack-Sjodin P.A., Margarit S.M., Bar-Sagi D., Kuriyan J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCNature 394:337-343 (1998)Mapped to11
Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1 (NF1).Klose A., Ahmadian M.R., Schuelke M., Scheffzek K., Hoffmeyer S., Gewies A., Schmitz F., Kaufmann D., Peters H.[...], Nuernberg P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCHum. Mol. Genet. 7:1261-1268 (1998)Cited in1Mapped to6
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.Hadari Y.R., Kouhara H., Lax I., Schlessinger J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCMol. Cell. Biol. 18:3966-3973 (1998)Cited in1Mapped to32
Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).Cheng M., Sexl V., Sherr C.J., Roussel M.F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCProc Natl Acad Sci U S A 95:1091-1096 (1998)Mapped to16
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP- hydrolysis reaction of Ras.Ahmadian M.R., Stege P., Scheffzek K., Wittinghofer A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-6802339, Reactome: R-HSA-6802347, Reactome: R-HSA-6802363, Reactome: R-HSA-6802446, Reactome: R-HSA-6802455, Reactome: R-HSA-6802461, Reactome: R-HSA-9647910, Reactome: R-HSA-9649657, Reactome: R-HSA-9649660, Reactome: R-HSA-9649662, Reactome: R-HSA-9649666, Reactome: R-HSA-9649669, Reactome: R-HSA-9649672, Reactome: R-HSA-9649675, Reactome: R-HSA-9649678, Reactome: R-HSA-9649680, Reactome: R-HSA-9656589PubMedEurope PMCNat Struct Biol 4:686-689 (1997)Mapped to16
Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.Kawada M., Yamagoe S., Murakami Y., Suzuki K., Mizuno S., Uehara Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCOncogene 15:629-637 (1997)Cited in1Mapped to7
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.Diaz B., Barnard D., Filson A., MacDonald S., King A., Marshall M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCMol Cell Biol 17:4509-4516 (1997)Mapped to19
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.Scheffzek K., Ahmadian M.R., Kabsch W., Wiesmuller L., Lautwein A., Schmitz F., Wittinghofer A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-6802339, Reactome: R-HSA-6802347, Reactome: R-HSA-6802363, Reactome: R-HSA-6802446, Reactome: R-HSA-6802455, Reactome: R-HSA-6802461, Reactome: R-HSA-9647910, Reactome: R-HSA-9649657, Reactome: R-HSA-9649660, Reactome: R-HSA-9649662, Reactome: R-HSA-9649666, Reactome: R-HSA-9649669, Reactome: R-HSA-9649672, Reactome: R-HSA-9649675, Reactome: R-HSA-9649678, Reactome: R-HSA-9649680, Reactome: R-HSA-9656589PubMedEurope PMCScience 277:333-338 (1997)Cited in2Mapped to14
Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.Aktas H., Cai H., Cooper G.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCMol Cell Biol 17:3850-3857 (1997)Mapped to7
DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2- Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells.Shen K., Novak R.F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCBiochem Biophys Res Commun 231:17-21 (1997)Mapped to8
Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.Besser D., Bardelli A., Didichenko S., Thelen M., Comoglio P.M., Ponzetto C., Nagamine Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCOncogene 14:705-711 (1997)Mapped to8
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.Marais R., Light Y., Paterson H.F., Mason C.S., Marshall C.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCJ Biol Chem 272:4378-4383 (1997)Mapped to42
The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras- dependent manner.Xia K., Mukhopadhyay N.K., Inhorn R.C., Barber D.L., Rose P.E., Lee R.S., Narsimhan R.P., D'Andrea A.D., Griffin J.D., Roberts T.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCProc Natl Acad Sci U S A 93:11681-11686 (1996)Mapped to18
Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons.Marsh H.N., Palfrey H.C.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCJ Neurochem 67:952-963 (1996)Mapped to9
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.Rodriguez-Viciana P., Warne P.H., Vanhaesebroeck B., Waterfield M.D., Downward J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCEMBO J 15:2442-2451 (1996)Mapped to7
Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.Migliaccio A., Di Domenico M., Castoria G., de Falco A., Bontempo P., Nola E., Auricchio F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCEMBO J 15:1292-1300 (1996)Mapped to8
Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells.Sepp-Lorenzino L., Eberhard I., Ma Z., Cho C., Serve H., Liu F., Rosen N., Lupu R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCOncogene 12:1679-1687 (1996)Mapped to14
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells.Bollag G., Clapp D.W., Shih S., Adler F., Zhang Y.Y., Thompson P., Lange B.J., Freedman M.H., McCormick F.[...], Shannon K.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCNat Genet 12:144-148 (1996)Mapped to7
Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu.Xie Y., Pendergast A.M., Hung M.C.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9647910PubMedEurope PMCJ Biol Chem 270:30717-30724 (1995)Mapped to18