The CST complex (CTC1-STN1-TEN1) maintains genome integrity through resolution of G4 structures both ahead of the replication fork and on the lagging strand template
Human cystatin SN suppresses allergic rhinitis (AR) symptoms through inhibiting allergen protease activities and protecting the nasal TJ barrier in an allergen-specific manner. We propose that upregulation of nasal endogenous protease inhibitors including cystatin SN is a novel therapeutic strategy for protease allergen-induced AR.
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