P00814 · DCTD_BPT2
- ProteinDeoxycytidylate deaminase
- GeneCD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids188 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Supplies the nucleotide substrate for thymidylate synthetase.
Catalytic activity
- dCMP + H+ + H2O = dUMP + NH4+
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Activity regulation
Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 19 | Zn2+ 1 (UniProtKB | ChEBI); structural | ||||
Sequence: C | ||||||
Binding site | 49 | Zn2+ 1 (UniProtKB | ChEBI); structural | ||||
Sequence: C | ||||||
Binding site | 94 | Zn2+ 1 (UniProtKB | ChEBI); structural | ||||
Sequence: H | ||||||
Binding site | 102 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 104 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 106 | Proton donor | ||||
Sequence: E | ||||||
Binding site | 132 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 135 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dCMP deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | nucleotide biosynthetic process | |
Biological Process | pyrimidine nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxycytidylate deaminase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Tevenvirinae > Tequatrovirus > Tequatrovirus T2
- Virus hosts
Accessions
- Primary accessionP00814
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000171700 | 1-188 | Deoxycytidylate deaminase | |||
Sequence: MKASTVLQIAYLVSQESKCCSWKVGAVIEKNGRIISTGYNGSPAGGVNCDNYAAIEGWLLNKPKHTIIQGHKPECVSFGTSDRFVLAKEHRSAHSEWSSKNEIHAELNAILFAARNGSSIEGATMYVTLSPCPDCAKAIAQSGIKKLVYCETYDKNKPGWDDILRNAGIEVFNVPKLNWENISEFCGE |
Interaction
Subunit
Homohexamer.
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-171 | CMP/dCMP-type deaminase | ||||
Sequence: MKASTVLQIAYLVSQESKCCSWKVGAVIEKNGRIISTGYNGSPAGGVNCDNYAAIEGWLLNKPKHTIIQGHKPECVSFGTSDRFVLAKEHRSAHSEWSSKNEIHAELNAILFAARNGSSIEGATMYVTLSPCPDCAKAIAQSGIKKLVYCETYDKNKPGWDDILRNAGIEV |
Sequence similarities
Belongs to the cytidine and deoxycytidylate deaminase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length188
- Mass (Da)20,599
- Last updated1986-07-21 v1
- ChecksumA13EAF89D5CEB14A
Keywords
- Technical term