P00785 · ACTN_ACTCC
- ProteinActinidain
- GeneACT1A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids380 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cysteine protease responsible for the cleavage of kiwellin into kissper and KiTH.
Activity regulation
Repressed by the active-site-directed cysteine protease inhibitor E64 (L-trans-epoxysuccinyl-leucylamide-(4-guanido)-butane) produced by Aspergillus japonicus.
Features
Showing features for active site, binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Molecular Function | cysteine-type endopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameActinidain
- EC number
- Short namesActinidin
- Allergen nameAct c 1
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > Ericales > Actinidiaceae > Actinidia
Accessions
- Primary accessionP00785
- Secondary accessions
Proteomes
Genome annotation databases
Phenotypes & Variants
Allergenic properties
Causes an allergic reaction in human.
Keywords
- Disease
Protein family/group databases
PTM/Processing
Features
Showing features for signal, propeptide, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MGLPKSFVSMSLLFFSTLLILSLA | ||||||
Propeptide | PRO_0000026398 | 25-126 | Activation peptide | |||
Sequence: FNAKNLTQRTNDEVKAMYESWLIKYGKSYNSLGEWERRFEIFKETLRFIDEHNADTNRSYKVGLNQFADLTDEEFRSTYLGFTSGSNKTKVSNQYEPRVGQV | ||||||
Chain | PRO_0000026399 | 127-380 | Actinidain | |||
Sequence: LPSYVDWRSAGAVVDIKSQGECGGCWAFSAIATVEGINKIVTGVLISLSEQELIDCGRTQNTRGCNVGYITDGFQFIINNGGINTEENYPYTAQDGECNVDLQNEKYVTIDTYENVPYNNEWALQTAVTYQPVSVALDAAGDAFKHYSSGIFIGPCGTAIDHAVTIVGYGTEGGIDYWIVKNSWDTTWGEEGYMRILRNVGGAGTCGIATMPSYPVKYNNQNHPKSYSSLINPPAFSMSNDGPVGVDDGQRYSA | ||||||
Disulfide bond | 148↔191 | |||||
Sequence: CGGCWAFSAIATVEGINKIVTGVLISLSEQELIDCGRTQNTRGC | ||||||
Disulfide bond | 182↔224 | |||||
Sequence: CGRTQNTRGCNVGYITDGFQFIINNGGINTEENYPYTAQDGEC | ||||||
Disulfide bond | 282↔332 | |||||
Sequence: CGTAIDHAVTIVGYGTEGGIDYWIVKNSWDTTWGEEGYMRILRNVGGAGTC |
Keywords
- PTM
Expression
Tissue specificity
Fruit.
Developmental stage
Levels of mRNA accumulate during early fruit development.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length380
- Mass (Da)42,098
- Last updated2019-11-13 v5
- ChecksumC2DA505454525B93
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 27 | in Ref. 1; ADQ85985 | ||||
Sequence: A → T | ||||||
Sequence conflict | 96 | in Ref. 5; CAA31435 | ||||
Sequence: D → G | ||||||
Sequence conflict | 108 | in Ref. 5; CAA31435 | ||||
Sequence: S → G | ||||||
Sequence conflict | 118 | in Ref. 1; ADQ85985/ADQ85986 | ||||
Sequence: Q → R | ||||||
Sequence conflict | 124 | in Ref. 5; CAA31435 | ||||
Sequence: G → S | ||||||
Sequence conflict | 167-170 | in Ref. 6; AA sequence | ||||
Sequence: VTGV → TSGS | ||||||
Sequence conflict | 181 | in Ref. 5; CAA31435 | ||||
Sequence: D → G | ||||||
Sequence conflict | 184 | in Ref. 5; CAA31435 | ||||
Sequence: R → G | ||||||
Sequence conflict | 192 | in Ref. 6; AA sequence | ||||
Sequence: N → D | ||||||
Sequence conflict | 193 | in Ref. 1; ADQ85985 | ||||
Sequence: V → G | ||||||
Sequence conflict | 193-194 | in Ref. 1; ADQ85986 | ||||
Sequence: VG → GS | ||||||
Sequence conflict | 201 | in Ref. 1; ADQ85986 | ||||
Sequence: Q → P | ||||||
Sequence conflict | 206 | in Ref. 6; AA sequence | ||||
Sequence: N → D | ||||||
Sequence conflict | 212 | in Ref. 5; CAA31435 | ||||
Sequence: E → G | ||||||
Sequence conflict | 223 | in Ref. 6; AA sequence | ||||
Sequence: E → D | ||||||
Sequence conflict | 225 | in Ref. 6; AA sequence | ||||
Sequence: N → D | ||||||
Sequence conflict | 226 | in Ref. 5; CAA31435 | ||||
Sequence: V → L | ||||||
Sequence conflict | 227 | in Ref. 6; AA sequence | ||||
Sequence: D → A | ||||||
Sequence conflict | 230-231 | in Ref. 6; AA sequence | ||||
Sequence: NE → DQ | ||||||
Sequence conflict | 240 | in Ref. 5; CAA31435 | ||||
Sequence: E → G | ||||||
Sequence conflict | 272 | in Ref. 1; ADQ85985/ADQ85986 | ||||
Sequence: H → Q | ||||||
Sequence conflict | 274 | in Ref. 6; AA sequence | ||||
Sequence: S → A | ||||||
Sequence conflict | 279 | in Ref. 1; ADQ85985/ADQ85986 | ||||
Sequence: I → T | ||||||
Sequence conflict | 290-291 | in Ref. 6; AA sequence | ||||
Sequence: VT → IV | ||||||
Sequence conflict | 301 | in Ref. 6; AA sequence | ||||
Sequence: I → V | ||||||
Sequence conflict | 307 | in Ref. 5; CAA31435 | ||||
Sequence: K → E | ||||||
Sequence conflict | 349 | in Ref. 5; CAA31435/CAA31529 | ||||
Sequence: H → Y | ||||||
Sequence conflict | 360 | in Ref. 5; CAA31435/CAA31529 | ||||
Sequence: P → S | ||||||
Sequence conflict | 366 | in Ref. 1; ADQ85985 | ||||
Sequence: N → K | ||||||
Sequence conflict | 373 | in Ref. 5; CAA31435/CAA31529 | ||||
Sequence: D → E | ||||||
Sequence conflict | 374 | in Ref. 5; CAA31529 | ||||
Sequence: D → H |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU201520 EMBL· GenBank· DDBJ | ADQ85985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU201528 EMBL· GenBank· DDBJ | ADQ85986.1 EMBL· GenBank· DDBJ | mRNA | ||
LC330913 EMBL· GenBank· DDBJ | BBA83994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF343446 EMBL· GenBank· DDBJ | AAK06862.1 EMBL· GenBank· DDBJ | mRNA | ||
NKQK01000011 EMBL· GenBank· DDBJ | PSS17271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X13013 EMBL· GenBank· DDBJ | CAA31435.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
X13139 EMBL· GenBank· DDBJ | CAA31529.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |