P00712 · LALBA_CAPHI

  • Protein
    Alpha-lactalbumin
  • Gene
    LALBA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Features

Showing features for binding site.

1142102030405060708090100110120130140
TypeIDPosition(s)Description
Binding site98Ca2+ (UniProtKB | ChEBI)
Binding site101Ca2+ (UniProtKB | ChEBI)
Binding site103Ca2+ (UniProtKB | ChEBI)
Binding site106Ca2+ (UniProtKB | ChEBI)
Binding site107Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentprotein-containing complex
Molecular Functioncalcium ion binding
Molecular Functionlactose synthase activity
Molecular Functionlysozyme activity
Biological Processdefense response to Gram-negative bacterium
Biological Processdefense response to Gram-positive bacterium
Biological Processlactose biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-lactalbumin
  • Alternative names
    • Lactose synthase B protein

Gene names

    • Name
      LALBA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    P00712

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000001844220-142Alpha-lactalbumin
Disulfide bond25↔139
Disulfide bond47↔130
Glycosylation64N-linked (GlcNAc...) asparagine
Disulfide bond80↔96
Disulfide bond92↔110
Glycosylation93N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Tissue specificity

Mammary gland specific. Secreted in milk.

Gene expression databases

Interaction

Subunit

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-142C-type lysozyme

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    142
  • Mass (Da)
    16,255
  • Last updated
    1988-11-01 v1
  • Checksum
    ABA2C83D821BE493
MMSFVSLLLVGILFHATQAEQLTKCEVFQKLKDLKDYGGVSLPEWVCTAFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSRNICNISCDKFLDDDLTDDIVCAKKILDKVGINYWLAHKALCSEKLDQWLCEKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X05149
EMBL· GenBank· DDBJ
CAA28797.1
EMBL· GenBank· DDBJ
mRNA
M63868
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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