P00634 · PPB_ECOLI
- ProteinAlkaline phosphatase
- GenephoA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids471 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- a phosphate monoester + H2O = an alcohol + phosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion.
Note: Binds 2 Zn2+ ions.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 73 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 73 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 124 | Phosphoserine intermediate | ||||
Sequence: S | ||||||
Binding site | 175 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 177 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 344 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 349 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 353 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 391 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 392 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 434 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | outer membrane-bounded periplasmic space | |
Cellular Component | periplasmic space | |
Molecular Function | alkaline phosphatase activity | |
Molecular Function | hydrogenase (acceptor) activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | oxidoreductase activity, acting on phosphorus or arsenic in donors | |
Molecular Function | phosphoprotein phosphatase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein dephosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkaline phosphatase
- EC number
- Short namesAPase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP00634
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 22 | in isozyme 3 | ||||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MKQSTIALALLPLLFTPVTKA | ||||||
Chain | PRO_0000024012 | 22-471 | Alkaline phosphatase | |||
Sequence: RTPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK | ||||||
Disulfide bond | 190↔200 | |||||
Sequence: CYGPSATSEKC | ||||||
Disulfide bond | 308↔358 | |||||
Sequence: CTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPC |
Keywords
- PTM
Proteomic databases
Interaction
Subunit
Isozymes 1 and 3 are a dimer of identical chains, isozyme 2 is a dimer of heterogeneous chains, one of each of the subunits from isozymes 1 and 3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P00634 | dsbA P0AEG4 | 2 | EBI-552958, EBI-549711 | |
XENO | P00634 | LRRK2 Q5S007 | 2 | EBI-552958, EBI-5323863 | |
BINARY | P00634 | secA P10408 | 3 | EBI-552958, EBI-543213 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length471
- Mass (Da)49,439
- Last updated1987-08-13 v1
- Checksum8A8DE1F29D9D9253
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 10 | in Ref. 12; AAA23431 | ||||
Sequence: L → V | ||||||
Sequence conflict | 78-80 | in Ref. 8; AAA24359 | ||||
Sequence: SEI → WGS | ||||||
Sequence conflict | 198 | in Ref. 9; AA sequence | ||||
Sequence: E → Q |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X04586 EMBL· GenBank· DDBJ | CAA28257.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M13345 EMBL· GenBank· DDBJ | AAA83893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M29664 EMBL· GenBank· DDBJ | AAA24364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M29665 EMBL· GenBank· DDBJ | AAA24365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U73857 EMBL· GenBank· DDBJ | AAB18107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U00096 EMBL· GenBank· DDBJ | AAC73486.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAE76164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M33536 EMBL· GenBank· DDBJ | AAA24372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AH000890 EMBL· GenBank· DDBJ | AAA24359.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AH000890 EMBL· GenBank· DDBJ | AAA24360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AH000890 EMBL· GenBank· DDBJ | AAA24361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
J05005 EMBL· GenBank· DDBJ | AAA24362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M14399 EMBL· GenBank· DDBJ | AAA23431.1 EMBL· GenBank· DDBJ | mRNA | ||
M13763 EMBL· GenBank· DDBJ | AAA24358.1 EMBL· GenBank· DDBJ | Genomic DNA |