P00534 · ERBB_ALV

  • Protein
    Tyrosine-protein kinase transforming protein erbB
  • Gene
    V-ERBB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Miscellaneous

This protein is produced by erythroleukemia cells in chickens which have been injected with the avian leukosis virus and subsequently develop leukemia. The leukemias are induced by the insertion of retroviral promoter elements in or near the c-erbB gene, which leads to c-erbB activation.
This protein is synthesized as a Gag-Env-ErbB protein.

Catalytic activity

Features

Showing features for binding site, active site.

163450100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site138-146ATP (UniProtKB | ChEBI)
Binding site165ATP (UniProtKB | ChEBI)
Active site257Proton acceptor

GO annotations

AspectTerm
Cellular Componentbasal plasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionepidermal growth factor binding
Molecular Functionepidermal growth factor receptor activity
Biological Processnegative regulation of apoptotic process
Biological Processneurogenesis
Biological Processpositive regulation of epithelial cell proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase transforming protein erbB
  • EC number

Gene names

    • Name
      V-ERBB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Alpharetrovirus
  • Virus hosts

Accessions

  • Primary accession
    P00534

Subcellular Location

Phenotypes & Variants

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001602511-634Tyrosine-protein kinase transforming protein erbB

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain132-399Protein kinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    634
  • Mass (Da)
    70,891
  • Last updated
    1999-07-15 v2
  • Checksum
    E705E33A0BE01FCC
MKCAHFIDGPHCVKACPAGVLGENDTLVWKYADANAVCQLCHPNCTRGCKGPGLEGCPNGSKTPSIAAGVVGGLLCLVVVGLGIGLYLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIAEFSKMARDPPRYLVIQGDERMHLPSPTDSKFYRTLMEEEDMEDIVDADEYLVPHQGFFNSPSTSRTPLLSSLSATSNNSATNCIDRNGQGHPVREDSFVQRYSSDPTGNFLEESIDDGFLPAPEYVNQLMPKKPSTAMVQNQIYNNISLTAISKLPMDSRYQNSHSTAVDNPEYLNTNQSPLAKTVFESSPYWIQSGNHQINLDNPDYQQDFLPNETKPNGLLKVPAAENPEYLRVAAPKSEYIEASA

Sequence caution

The sequence AAA48763.1 differs from that shown. Reason: Erroneous initiation

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M10066
EMBL· GenBank· DDBJ
AAA48763.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Similar Proteins

Disclaimer

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