P00412 · COX2_MAIZE

  • Protein
    Cytochrome c oxidase subunit 2
  • Gene
    COX2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a dinuclear copper A center per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site189Cu cation A1 (UniProtKB | ChEBI)
Binding site224Cu cation A1 (UniProtKB | ChEBI)
Binding site224Cu cation A2 (UniProtKB | ChEBI)
Binding site226Cu cation A2 (UniProtKB | ChEBI)
Binding site226Mg2+ (UniProtKB | ChEBI); ligand shared with subunit 1
Binding site228Cu cation A1 (UniProtKB | ChEBI)
Binding site228Cu cation A2 (UniProtKB | ChEBI)
Binding site232Cu cation A2 (UniProtKB | ChEBI)
Binding site235Cu cation A1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological Processelectron transport chain

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2
  • EC number
  • Alternative names
    • Cytochrome c oxidase polypeptide II

Gene names

    • Name
      COX2
    • Synonyms
      COXII, MOX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Golden Bantam early
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Andropogonodae > Andropogoneae > Tripsacinae > Zea

Accessions

  • Primary accession
    P00412

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-43Mitochondrial intermembrane
Transmembrane44-64Helical
Topological domain65-84Mitochondrial matrix
Transmembrane85-105Helical
Topological domain106-260Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001836291-260Cytochrome c oxidase subunit 2

Proteomic databases

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    260
  • Mass (Da)
    29,680
  • Last updated
    1996-10-01 v4
  • Checksum
    2F90F35CFB1A702F
MILRLLECRFFTIALCDAAEPWQLGFQDAATPMMQGIIDLHHDIFFFLILILVFVLWMLVRALWHFNEQTNPIPQRIVHGTTIEIIWTIFPSVILLFIAIPSFALLYSMDGVLVDPAITIKAIGHQWYWTYEYSDYNSSDEQSLTFDSYMIPEDDLELGQLRLLEVDNRVVVPAKTHLRMIVTSADVLHSWAVPSLGVKCDAVPGRLNLTSILVQREGVYYGQCSEICGTNHAFMPIVVEAVTLKDYADWVSNQLILQTN

RNA Editing

Edited at positions 5
11
26
56
57
87
95
129
130
150
156
161
184
188
196
207
213
235

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
V00712
EMBL· GenBank· DDBJ
CAA24094.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
X52865
EMBL· GenBank· DDBJ
CAA37046.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Similar Proteins

Disclaimer

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