P00334 · ADH_DROME
- ProteinAlcohol dehydrogenase
- GeneAdh
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids256 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- a primary alcohol + NAD+ = an aldehyde + H+ + NADH
Activity regulation
Inhibited by 2,2,2-trifluoroethanol and pyrazole.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | acetaldehyde dehydrogenase (acetylating) activity | |
Molecular Function | alcohol dehydrogenase (NAD+) activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | acetaldehyde metabolic process | |
Biological Process | acetyl-CoA biosynthetic process from ethanol | |
Biological Process | alcohol catabolic process | |
Biological Process | alcohol metabolic process | |
Biological Process | behavioral response to ethanol | |
Biological Process | ethanol metabolic process | |
Biological Process | NADH metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlcohol dehydrogenase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP00334
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 9 | in allele Adh-UF | ||||
Sequence: N → V | ||||||
Mutagenesis | 15 | 31% decrease in activity. | ||||
Sequence: G → A | ||||||
Mutagenesis | 15 | In Adh-N11; loss of activity. | ||||
Sequence: G → D | ||||||
Mutagenesis | 15 | Complete loss of activity. | ||||
Sequence: G → V | ||||||
Natural variant | 46 | in allele Adh-UF | ||||
Sequence: A → D | ||||||
Natural variant | 46 | in strain: NC16 | ||||
Sequence: A → V | ||||||
Natural variant | 52 | in allele Adh-F' | ||||
Sequence: A → E | ||||||
Natural variant | 71 | in strain: NC16 | ||||
Sequence: A → S | ||||||
Mutagenesis | 130 | Complete loss of activity. | ||||
Sequence: G → C | ||||||
Mutagenesis | 133 | Complete loss of activity. | ||||
Sequence: G → I | ||||||
Mutagenesis | 136 | No decrease in activity. | ||||
Sequence: C → A | ||||||
Mutagenesis | 153 | Retains only 0.25% activity. | ||||
Sequence: Y → C | ||||||
Mutagenesis | 153 | Complete loss of activity. | ||||
Sequence: Y → F, H, E, or Q | ||||||
Mutagenesis | 157 | Complete loss of activity. | ||||
Sequence: K → I | ||||||
Mutagenesis | 157 | Retains only 2.2% activity. | ||||
Sequence: K → R | ||||||
Mutagenesis | 184 | Complete loss of activity. | ||||
Sequence: G → L | ||||||
Natural variant | 193 | in allele Adh-F, allele Adh-F-CHD, allele Adh-71K, allele Adh-JA-F and in strain: Berkeley | ||||
Sequence: K → T | ||||||
Natural variant | 215 | in allele Adh-F-CHD and allele Adh-71K | ||||
Sequence: P → S | ||||||
Mutagenesis | 219 | No decrease in activity. | ||||
Sequence: C → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000054474 | 2-256 | Alcohol dehydrogenase | |||
Sequence: SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKHWDSGI |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)27,761
- Last updated2007-01-23 v2
- ChecksumEB4DF91029007284
Polymorphism
Virtually all natural populations of this species are polymorphic for 2 electrophoretically distinguishable alleles, Adh-S and Adh-F (PubMed:12537569, PubMed:1673107, PubMed:1683848, PubMed:6410283, PubMed:6780981, PubMed:6789320, PubMed:6821373, Ref.12, Ref.18). The sequence of the Adh-S allele is shown (PubMed:12537569, PubMed:1673107, PubMed:6410283, PubMed:6789320, PubMed:6821373, Ref.12, Ref.18). Other naturally occurring alleles include Adh-JA-F, Adh-AF-S, Adh-F-CHD, Adh-71K, Adh-UF and Adh-F' (PubMed:115502, PubMed:2124644, PubMed:3021568, PubMed:3137352, PubMed:6789328, PubMed:6821373).
Artificially induced mutations include Adh-NB, Adh-NLA248, Adh-N4 and Adh-N11 (PubMed:2419573, PubMed:3108863, PubMed:3928896, PubMed:6818527, PubMed:6821373).
Artificially induced mutations include Adh-NB, Adh-NLA248, Adh-N4 and Adh-N11 (PubMed:2419573, PubMed:3108863, PubMed:3928896, PubMed:6818527, PubMed:6821373).
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M17827 EMBL· GenBank· DDBJ | AAA28341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17828 EMBL· GenBank· DDBJ | AAA28342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M19547 EMBL· GenBank· DDBJ | AAA70210.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17830 EMBL· GenBank· DDBJ | AAA28343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17831 EMBL· GenBank· DDBJ | AAA28344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17832 EMBL· GenBank· DDBJ | AAA28345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17833 EMBL· GenBank· DDBJ | AAA28346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17834 EMBL· GenBank· DDBJ | AAA28347.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17835 EMBL· GenBank· DDBJ | AAA28348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17836 EMBL· GenBank· DDBJ | AAA28349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17837 EMBL· GenBank· DDBJ | AAA70212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z00030 EMBL· GenBank· DDBJ | CAA77330.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M22210 EMBL· GenBank· DDBJ | AAA28338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M57239 EMBL· GenBank· DDBJ | AAA28330.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X78384 EMBL· GenBank· DDBJ | CAA55151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M36580 EMBL· GenBank· DDBJ | AAA28331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X60791 EMBL· GenBank· DDBJ | CAA43204.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X60792 EMBL· GenBank· DDBJ | CAA43205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X60793 EMBL· GenBank· DDBJ | CAA43206.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U20765 EMBL· GenBank· DDBJ | AAA88817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X98338 EMBL· GenBank· DDBJ | CAA66981.1 EMBL· GenBank· DDBJ | mRNA | ||
AF175211 EMBL· GenBank· DDBJ | AAF00229.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175212 EMBL· GenBank· DDBJ | AAF00230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175213 EMBL· GenBank· DDBJ | AAF00231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175214 EMBL· GenBank· DDBJ | AAF00232.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175215 EMBL· GenBank· DDBJ | AAF00233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175216 EMBL· GenBank· DDBJ | AAF00234.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175217 EMBL· GenBank· DDBJ | AAF00235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175218 EMBL· GenBank· DDBJ | AAF00236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175219 EMBL· GenBank· DDBJ | AAF00237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF175220 EMBL· GenBank· DDBJ | AAF00238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAO41197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAO41199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAO41200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAO41201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY060227 EMBL· GenBank· DDBJ | AAL25266.1 EMBL· GenBank· DDBJ | mRNA | ||
BT012435 EMBL· GenBank· DDBJ | AAS93706.1 EMBL· GenBank· DDBJ | mRNA | ||
M17845 EMBL· GenBank· DDBJ | AAA28363.1 EMBL· GenBank· DDBJ | Genomic DNA |