O97961 · KTN1_VULVU
- ProteinKinectin
- GeneKTN1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1330 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for kinesin thus involved in kinesin-driven vesicle motility.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | kinesin binding | |
Biological Process | microtubule-based movement | |
Biological Process | protein transport |
Names & Taxonomy
Protein names
- Recommended nameKinectin
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Vulpes
Accessions
- Primary accessionO97961
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Note: Vesicle membrane protein anchored to the endoplasmic reticulum. In testis, localized at sperm surface.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-6 | Cytoplasmic | ||||
Sequence: MEFYES | ||||||
Transmembrane | 7-29 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: TYFIVLIPSVVITVIFLFFWLFM | ||||||
Topological domain | 30-1330 | Lumenal | ||||
Sequence: KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDEQVVPIPLNVVETSSSVRERKKKEKKHKPVLEEQVTKESDVSKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMAPSKKQESLPLQQETKQESGSGKKKVSSKKQKAENVLVDEPLIHATTYIPLMDNADSNPVLDKREVIDLIKPDQVEGIQKTGAKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKRSSKGELTALVHQLQEKDKLLAAVKEDAAVMKDRCKQLTQEMMSEKERSNVVIARMKDRIGTLEKEHNVFQNKMHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAVTQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVTKEESLQMQVQDILEQNEALKALIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLANEHDHLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQKSIHVKDDQIRLLEEQLQCEISNKMEEFKILNDQNKALQLEVQKLQILVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEVLKVANKEKTIQDLKQEIEALKEEIGNIQLEKAQQLSITSQIQELQNLLKGKEEQMNTMKTVLEEKEKDLASRGKWLQDLQEENESLKTHIQEVAQHNLKEACSASRLEELETVLKEKENEMKRIETILKERENDLSSKIKLLQEVQDENKLFKSEIEQLKQCNYQQASSFPPHEELLKVISEREKEITGLQNELDSLKEAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKVERQQYVEAIELEAKEVLKKLFPKVSVPPNLNYGEWLRGFEKKPKECVAETSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESQKTIKQMQLSFTSSEQELERLRRENKDIENLRREREHLEMELEKAEIERSTYVTEVRELKTQLNETLTKLRTEQSERQKVAGDLHKAQQSLDLIQSKIVKAAGDTTVIENSDVSPEAESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000084338 | 1-1330 | Kinectin | |||
Sequence: MEFYESTYFIVLIPSVVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDEQVVPIPLNVVETSSSVRERKKKEKKHKPVLEEQVTKESDVSKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMAPSKKQESLPLQQETKQESGSGKKKVSSKKQKAENVLVDEPLIHATTYIPLMDNADSNPVLDKREVIDLIKPDQVEGIQKTGAKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKRSSKGELTALVHQLQEKDKLLAAVKEDAAVMKDRCKQLTQEMMSEKERSNVVIARMKDRIGTLEKEHNVFQNKMHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAVTQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVTKEESLQMQVQDILEQNEALKALIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLANEHDHLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQKSIHVKDDQIRLLEEQLQCEISNKMEEFKILNDQNKALQLEVQKLQILVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEVLKVANKEKTIQDLKQEIEALKEEIGNIQLEKAQQLSITSQIQELQNLLKGKEEQMNTMKTVLEEKEKDLASRGKWLQDLQEENESLKTHIQEVAQHNLKEACSASRLEELETVLKEKENEMKRIETILKERENDLSSKIKLLQEVQDENKLFKSEIEQLKQCNYQQASSFPPHEELLKVISEREKEITGLQNELDSLKEAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKVERQQYVEAIELEAKEVLKKLFPKVSVPPNLNYGEWLRGFEKKPKECVAETSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESQKTIKQMQLSFTSSEQELERLRRENKDIENLRREREHLEMELEKAEIERSTYVTEVRELKTQLNETLTKLRTEQSERQKVAGDLHKAQQSLDLIQSKIVKAAGDTTVIENSDVSPEAESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE | ||||||
Modified residue | 75 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 77 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 153 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 156 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 172 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 435 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 772 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 904 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1055 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 1085 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 1236 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 1286 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 1302 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Expressed in male brain, heart, kidney, liver, lung, spleen and testis.
Interaction
Subunit
Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 49-81 | Disordered | ||||
Sequence: PTKTDKKKAEKKKNKKKEIQNGNLHESDSESVP | ||||||
Compositional bias | 63-81 | Basic and acidic residues | ||||
Sequence: KKKEIQNGNLHESDSESVP | ||||||
Region | 108-218 | Disordered | ||||
Sequence: SSSVRERKKKEKKHKPVLEEQVTKESDVSKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMAPSKKQESLPLQQETKQESGSGKKKVSSKKQKA | ||||||
Compositional bias | 120-139 | Basic and acidic residues | ||||
Sequence: KHKPVLEEQVTKESDVSKIP | ||||||
Compositional bias | 162-186 | Basic and acidic residues | ||||
Sequence: KKKPGQKKSKNGSDDQDKKVETLMA | ||||||
Compositional bias | 203-218 | Basic and acidic residues | ||||
Sequence: ESGSGKKKVSSKKQKA | ||||||
Coiled coil | 332-1329 | |||||
Sequence: HQLQEKDKLLAAVKEDAAVMKDRCKQLTQEMMSEKERSNVVIARMKDRIGTLEKEHNVFQNKMHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAVTQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVTKEESLQMQVQDILEQNEALKALIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLANEHDHLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQKSIHVKDDQIRLLEEQLQCEISNKMEEFKILNDQNKALQLEVQKLQILVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEVLKVANKEKTIQDLKQEIEALKEEIGNIQLEKAQQLSITSQIQELQNLLKGKEEQMNTMKTVLEEKEKDLASRGKWLQDLQEENESLKTHIQEVAQHNLKEACSASRLEELETVLKEKENEMKRIETILKERENDLSSKIKLLQEVQDENKLFKSEIEQLKQCNYQQASSFPPHEELLKVISEREKEITGLQNELDSLKEAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKVERQQYVEAIELEAKEVLKKLFPKVSVPPNLNYGEWLRGFEKKPKECVAETSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESQKTIKQMQLSFTSSEQELERLRRENKDIENLRREREHLEMELEKAEIERSTYVTEVRELKTQLNETLTKLRTEQSERQKVAGDLHKAQQSLDLIQSKIVKAAGDTTVIENSDVSPEAESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL |
Sequence similarities
Belongs to the kinectin family.
Keywords
- Domain
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
O97961-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,330
- Mass (Da)153,478
- Last updated1999-05-01 v1
- ChecksumCDCDD415B274F42B
O97961-2
- Name2
- Differences from canonical
- 834-856: Missing
O97961-3
- Name3
- Differences from canonical
- 1031-1060: Missing
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q7T7G2 | A0A3Q7T7G2_VULVU | KTN1 | 1491 | ||
A0A3Q7T7G3 | A0A3Q7T7G3_VULVU | KTN1 | 1460 | ||
A0A3Q7S9N6 | A0A3Q7S9N6_VULVU | KTN1 | 1490 | ||
A0A3Q7SJ65 | A0A3Q7SJ65_VULVU | KTN1 | 1357 | ||
A0A3Q7TMS6 | A0A3Q7TMS6_VULVU | KTN1 | 1519 | ||
A0A3Q7TMU2 | A0A3Q7TMU2_VULVU | KTN1 | 1468 | ||
A0A3Q7SLQ9 | A0A3Q7SLQ9_VULVU | KTN1 | 1496 | ||
A0A3Q7SLR4 | A0A3Q7SLR4_VULVU | KTN1 | 1462 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 63-81 | Basic and acidic residues | ||||
Sequence: KKKEIQNGNLHESDSESVP | ||||||
Compositional bias | 120-139 | Basic and acidic residues | ||||
Sequence: KHKPVLEEQVTKESDVSKIP | ||||||
Compositional bias | 162-186 | Basic and acidic residues | ||||
Sequence: KKKPGQKKSKNGSDDQDKKVETLMA | ||||||
Compositional bias | 203-218 | Basic and acidic residues | ||||
Sequence: ESGSGKKKVSSKKQKA | ||||||
Alternative sequence | VSP_007983 | 834-856 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007984 | 1031-1060 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term