O96542 · O96542_DROME
- ProteinEnhancer of polycomb-like protein
- GeneE(Pc)
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2023 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | histone acetyltransferase complex | |
Cellular Component | NuA4 histone acetyltransferase complex | |
Cellular Component | nucleus | |
Cellular Component | piccolo histone acetyltransferase complex | |
Cellular Component | polytene chromosome | |
Biological Process | chromatin organization | |
Biological Process | dendrite guidance | |
Biological Process | DNA repair | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEnhancer of polycomb-like protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionO96542
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-139 | Enhancer of polycomb-like N-terminal | ||||
Sequence: RARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICTGLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQQQRLELTELKFEQMMDRLEK | ||||||
Region | 346-429 | Disordered | ||||
Sequence: AISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADS | ||||||
Compositional bias | 359-373 | Basic residues | ||||
Sequence: EKRPYKKRKHKLPRD | ||||||
Compositional bias | 376-394 | Polar residues | ||||
Sequence: QHQQQQTQQHQQQQYLPAS | ||||||
Region | 578-623 | Disordered | ||||
Sequence: PAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKF | ||||||
Compositional bias | 587-622 | Basic and acidic residues | ||||
Sequence: HPVPELIKEEPSSDTEKPVAATESGRESKERELEEK | ||||||
Coiled coil | 655-682 | |||||
Sequence: CADLRQKRRRLRRKKQQLRELNAAKRLK | ||||||
Region | 682-702 | Disordered | ||||
Sequence: KRSSEAVATAEDVQLEDEDTK | ||||||
Region | 748-784 | Disordered | ||||
Sequence: PEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNV | ||||||
Compositional bias | 752-784 | Polar residues | ||||
Sequence: QPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNV | ||||||
Region | 1661-1685 | Disordered | ||||
Sequence: ATSTGNSGDQMETGDGLQQQQQQQQ | ||||||
Region | 1973-1992 | Disordered | ||||
Sequence: PTSNNNNNNNGSGAGGNGGP |
Sequence similarities
Belongs to the enhancer of polycomb family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,023
- Mass (Da)220,679
- Last updated1999-05-01 v1
- Checksum4A8E71E5A998249A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 359-373 | Basic residues | ||||
Sequence: EKRPYKKRKHKLPRD | ||||||
Compositional bias | 376-394 | Polar residues | ||||
Sequence: QHQQQQTQQHQQQQYLPAS | ||||||
Compositional bias | 587-622 | Basic and acidic residues | ||||
Sequence: HPVPELIKEEPSSDTEKPVAATESGRESKERELEEK | ||||||
Compositional bias | 752-784 | Polar residues | ||||
Sequence: QPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNV |