O96542 · O96542_DROME

Function

function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthistone acetyltransferase complex
Cellular ComponentNuA4 histone acetyltransferase complex
Cellular Componentnucleus
Cellular Componentpiccolo histone acetyltransferase complex
Cellular Componentpolytene chromosome
Biological Processchromatin organization
Biological Processdendrite guidance
Biological ProcessDNA repair
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Enhancer of polycomb-like protein

Gene names

    • Name
      E(Pc)
    • ORF names
      CG7776

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    O96542

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain7-139Enhancer of polycomb-like N-terminal
Region346-429Disordered
Compositional bias359-373Basic residues
Compositional bias376-394Polar residues
Region578-623Disordered
Compositional bias587-622Basic and acidic residues
Coiled coil655-682
Region682-702Disordered
Region748-784Disordered
Compositional bias752-784Polar residues
Region1661-1685Disordered
Region1973-1992Disordered

Sequence similarities

Belongs to the enhancer of polycomb family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,023
  • Mass (Da)
    220,679
  • Last updated
    1999-05-01 v1
  • Checksum
    4A8E71E5A998249A
MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICTGLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQQQRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHPLILTVKTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKRDHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPTGLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADSEEEDYFGAGAQNGNKLGSESEEETPFAFRRRSSCVYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTLTSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKPGDPDQLCKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKFENDVDDEFVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLKRSSEAVATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVSENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQEAEELVGGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGPSLEEVAKTIKREMIDADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSIIRHTAVKKELEAQQHQQQVQHEQMQAARKMEEDEAAPCLNQLPDVIRLRNIRNSQVHARPKDLFVQAPVDEEFNADYMGGLSPTSSQRLDICNELLSEIRRDWLHFRPKTPTDELSDSQDCEVGKTCDSHAVDWTQGTPISVELNRLGKREAEESDSSSYFLSSGFKYRDLESDAQLLQTVQAQDYARGSSKSPNCSGSGSGSALEFNLSGGDSLNDINNLLGCDDEDDNHEHMLDNILQECAMDDPKALNQATNFWNGILDGEAAVDEVEMADQLLDCIDEKKSKVGAADTSKRAGRNRKARLIQAPVGSSAFTVCPTAETLKERELFFSQAPPVEVPPKEKTPAEVELPEVVVKETANLPVKVEAVEKPQSEVLPVAPQPQQLQPQAITLPTTQLINIPAQISTQKQHQQPQVTQLLNQFANAGPQIIARTEYGGGAAVGDIVTITPHTGSSPLPTLTAQQQLQHQLAQAQLRNVTVQQRQATPQNPNQNQNPQQQLLFQMQRDPSRSLTPLQAAGAGATGNHLIYTTSCGEIVTAGAAASASQKVTYAIQKAGVSSGGATTASIGPNTVITLSNVKVQNDDISSGGSGNSGSSVNIINTASGQQLAVHSIAGMQQQGQQQVQQVTTSTPLLVATPTRNNVQQQQQQLVQQQPIVWRQVSGTNTAVATTAVLSTTVDSSPKAVTNQILWTSRATQKRQLNGPENTDINKLLLNRKLPRKQQIQQQHQQIQLTKQQLQQLVQHEELDDLVATSTGNSGDQMETGDGLQQQQQQQQQQQQLQKLSKVIKMSQFPLLVSDVSLQQQQSVSGQAQQQQLKPNSAAAIAANHNYSLHPASTAIITAQATPQQANKIFLTSSNSGGGGSAGNFTIATASELQAAAAGQKLHYKELPNSNLKLNFVSSAGTGEQTQQVGATTVLLNKSQQQQQQQQHQKLKTLATTGNSQTGQGDKRVLYTSLLNVKPLQKNNSGQMQMQLGPGGLQQVLRGRLNNSAIITRTLPLGTTVNSTGGAVGPTTTTIRQLVTTNANNVSSQDGNLLSAKEVGKALTVEQVIASANNGGVVLPTSNNNNNNNGSGAGGNGGPLNSGVNATGAGGGGSTGAGVGGAGVTSTINR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias359-373Basic residues
Compositional bias376-394Polar residues
Compositional bias587-622Basic and acidic residues
Compositional bias752-784Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF079764
EMBL· GenBank· DDBJ
AAC64271.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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