O96425 · O96425_LEPSE

  • Protein
    Glyceraldehyde-3-phosphate dehydrogenase
  • Gene
    GAPDH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Features

Showing features for binding site, active site, site.

136150100150200250300350
TypeIDPosition(s)Description
Binding site13-14NAD+ (UniProtKB | ChEBI)
Binding site39NAD+ (UniProtKB | ChEBI)
Binding site93NAD+ (UniProtKB | ChEBI)
Binding site135NAD+ (UniProtKB | ChEBI)
Binding site166-168D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site167Nucleophile
Site195Activates thiol group during catalysis
Binding site198D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site227-228D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site250D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site336NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Biological Processglucose metabolic process
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glyceraldehyde-3-phosphate dehydrogenase
  • EC number

Gene names

    • Name
      GAPDH
    • ORF names
      ABL78_8396

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30220
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas

Accessions

  • Primary accession
    O96425

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-167Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    39,054
  • Last updated
    1999-05-01 v1
  • Checksum
    68300E387B68B22C
MAPLKVGINGFGRIGRMVFQSMCEDNVLGNEIDVVAVVDMSTDAEYFAYQMKYDTVHGRPKYTVEVAKSSAAVKKPDVLVVNGHRILCVKAQRNPADLPWGKLGVDYVIESTGLFTDKVKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQNEYDSAKHHVVSNASCTTNCLAPIVHVLTKEGFGVETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASKTYMKGILGFTDEELVSADFINDARSSIYDSKATLQNNLPGEKRFFKVVSWYDNEWGYSHRVVDLVRFMGAKDRASSKM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF047495
EMBL· GenBank· DDBJ
AAD02467.1
EMBL· GenBank· DDBJ
Genomic DNA
LJSK01000707
EMBL· GenBank· DDBJ
KPI82594.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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