O96014 · WNT11_HUMAN

  • Protein
    Protein Wnt-11
  • Gene
    WNT11
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functionfrizzled binding
Molecular FunctionGTPase activator activity
Molecular Functionprotein kinase activator activity
Biological Processadrenal gland development
Biological Processartery morphogenesis
Biological Processatrial septum development
Biological Processbicellular tight junction assembly
Biological Processbone mineralization
Biological Processcanonical Wnt signaling pathway
Biological Processcell fate commitment
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to retinoic acid
Biological Processcloacal septation
Biological Processconvergent extension involved in axis elongation
Biological Processembryonic skeletal system development
Biological Processepithelial cell apoptotic process
Biological Processepithelial to mesenchymal transition
Biological Processlung-associated mesenchyme development
Biological Processmaintenance of epithelial cell apical/basal polarity
Biological Processmesenchymal cell proliferation
Biological Processmesonephric duct development
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of cartilage development
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of fibroblast growth factor production
Biological Processnegative regulation of mesenchymal cell proliferation
Biological Processnegative regulation of stem cell proliferation
Biological Processneuroendocrine cell differentiation
Biological Processneuron differentiation
Biological Processnotochord morphogenesis
Biological Processosteoblast differentiation
Biological Processoutflow tract morphogenesis
Biological Processparaxial mesoderm formation
Biological Processplanar cell polarity pathway involved in axis elongation
Biological Processplanar cell polarity pathway involved in gastrula mediolateral intercalation
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of epithelial cell apoptotic process
Biological Processpositive regulation of GTPase activity
Biological Processpositive regulation of protein kinase C signaling
Biological Processpositive regulation of stress fiber assembly
Biological Processpositive regulation of transforming growth factor beta2 production
Biological Processprimary heart field specification
Biological Processprotein localization to cell surface
Biological Processprotein phosphorylation
Biological Processresponse to nutrient levels
Biological Processsecondary heart field specification
Biological Processsecondary palate development
Biological Processsignal transduction
Biological Processsomite development
Biological Processstem cell proliferation
Biological Processureteric bud morphogenesis
Biological Processventricular septum morphogenesis
Biological ProcessWnt signaling pathway, calcium modulating pathway
Biological ProcessWnt signaling pathway, planar cell polarity pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Wnt-11

Gene names

    • Name
      WNT11

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O96014
  • Secondary accessions
    • B2R8Z6
    • Q14DE8
    • Q8WZ98

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 416 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000004146525-354Protein Wnt-11
Glycosylation40N-linked (GlcNAc...) asparagine
Disulfide bond80↔91
Glycosylation90N-linked (GlcNAc...) asparagine
Disulfide bond130↔138
Disulfide bond140↔157
Glycosylation160N-linked (GlcNAc...) asparagine
Disulfide bond209↔223
Disulfide bond211↔218
Lipidation215O-palmitoleoyl serine; by PORCN
Disulfide bond283↔314
Disulfide bond299↔309
Glycosylation300N-linked (GlcNAc...) asparagine
Glycosylation304N-linked (GlcNAc...) asparagine
Disulfide bond313↔353
Disulfide bond329↔344
Disulfide bond331↔341
Disulfide bond336↔337

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.

Gene expression databases

Organism-specific databases

Structure

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    354
  • Mass (Da)
    39,179
  • Last updated
    2002-05-10 v2
  • Checksum
    0E29717C98541DBB
MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict121in Ref. 1; CAA74159/CAA73223
Sequence conflict156in Ref. 1; CAA74159/CAA73223
Sequence conflict271in Ref. 1; CAA74159/CAA73223

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y13843
EMBL· GenBank· DDBJ
CAA74159.1
EMBL· GenBank· DDBJ
Genomic DNA
Y13844
EMBL· GenBank· DDBJ
CAA74159.1
EMBL· GenBank· DDBJ
Genomic DNA
Y13845
EMBL· GenBank· DDBJ
CAA74159.1
EMBL· GenBank· DDBJ
Genomic DNA
Y13846
EMBL· GenBank· DDBJ
CAA74159.1
EMBL· GenBank· DDBJ
Genomic DNA
Y13847
EMBL· GenBank· DDBJ
CAA74159.1
EMBL· GenBank· DDBJ
Genomic DNA
Y12692
EMBL· GenBank· DDBJ
CAA73223.1
EMBL· GenBank· DDBJ
mRNA
AB070218
EMBL· GenBank· DDBJ
BAB72099.1
EMBL· GenBank· DDBJ
mRNA
AK313570
EMBL· GenBank· DDBJ
BAG36343.1
EMBL· GenBank· DDBJ
mRNA
BC074790
EMBL· GenBank· DDBJ
AAH74790.1
EMBL· GenBank· DDBJ
mRNA
BC074791
EMBL· GenBank· DDBJ
AAH74791.1
EMBL· GenBank· DDBJ
mRNA
BC113386
EMBL· GenBank· DDBJ
AAI13387.1
EMBL· GenBank· DDBJ
mRNA
BC113388
EMBL· GenBank· DDBJ
AAI13389.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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