O96014 · WNT11_HUMAN
- ProteinProtein Wnt-11
- GeneWNT11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids354 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein Wnt-11
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO96014
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 416 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MRARPQVCEALLFALALQTGVCYG | ||||||
Chain | PRO_0000041465 | 25-354 | Protein Wnt-11 | |||
Sequence: IKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK | ||||||
Glycosylation | 40 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 80↔91 | |||||
Sequence: CRRAFADMRWNC | ||||||
Glycosylation | 90 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 130↔138 | |||||
Sequence: CTSGDLPGC | ||||||
Disulfide bond | 140↔157 | |||||
Sequence: CGPVPGEPPGPGNRWGGC | ||||||
Glycosylation | 160 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 209↔223 | |||||
Sequence: CKCHGVSGSCSIRTC | ||||||
Disulfide bond | 211↔218 | |||||
Sequence: CHGVSGSC | ||||||
Lipidation | 215 | O-palmitoleoyl serine; by PORCN | ||||
Sequence: S | ||||||
Disulfide bond | 283↔314 | |||||
Sequence: CMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCC | ||||||
Disulfide bond | 299↔309 | |||||
Sequence: CNKTSNGSDSC | ||||||
Glycosylation | 300 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 304 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 313↔353 | |||||
Sequence: CCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVC | ||||||
Disulfide bond | 329↔344 | |||||
Sequence: CHCKYHWCCYVTCRRC | ||||||
Disulfide bond | 331↔341 | |||||
Sequence: CKYHWCCYVTC | ||||||
Disulfide bond | 336↔337 | |||||
Sequence: CC |
Post-translational modification
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length354
- Mass (Da)39,179
- Last updated2002-05-10 v2
- Checksum0E29717C98541DBB
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 121 | in Ref. 1; CAA74159/CAA73223 | ||||
Sequence: A → T | ||||||
Sequence conflict | 156 | in Ref. 1; CAA74159/CAA73223 | ||||
Sequence: G → R | ||||||
Sequence conflict | 271 | in Ref. 1; CAA74159/CAA73223 | ||||
Sequence: S → W |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y13843 EMBL· GenBank· DDBJ | CAA74159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y13844 EMBL· GenBank· DDBJ | CAA74159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y13845 EMBL· GenBank· DDBJ | CAA74159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y13846 EMBL· GenBank· DDBJ | CAA74159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y13847 EMBL· GenBank· DDBJ | CAA74159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y12692 EMBL· GenBank· DDBJ | CAA73223.1 EMBL· GenBank· DDBJ | mRNA | ||
AB070218 EMBL· GenBank· DDBJ | BAB72099.1 EMBL· GenBank· DDBJ | mRNA | ||
AK313570 EMBL· GenBank· DDBJ | BAG36343.1 EMBL· GenBank· DDBJ | mRNA | ||
BC074790 EMBL· GenBank· DDBJ | AAH74790.1 EMBL· GenBank· DDBJ | mRNA | ||
BC074791 EMBL· GenBank· DDBJ | AAH74791.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113386 EMBL· GenBank· DDBJ | AAI13387.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113388 EMBL· GenBank· DDBJ | AAI13389.1 EMBL· GenBank· DDBJ | mRNA |